Delving into the Latest Updates on Institut des Biomolécules Max Mousseron with Synapse

概览

疾病领域	数量

感染	1
神经系统疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	2
合成多肽	1

排名前五的靶点	数量

5-HT6 receptor(5-羟色胺受体6)	1
Tubulin(微管蛋白)	1

关联

3

项与 Institut des Biomolécules Max Mousseron 相关的药物

ATCs

靶点-

作用机制-

在研机构

Institut des Biomolécules Max Mousseron

原研机构

Institut des Biomolécules Max Mousseron

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

PZ-1388

靶点

5-HT6 receptor

作用机制

5-HT6 receptor激动剂

在研机构

Polish Academy of Sciences [+3]

原研机构

Uniwersytet Jagiellonski

在研适应症

神经痛

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

EAPB-02303

靶点

Tubulin

作用机制

微管蛋白抑制剂

在研机构

4P-Pharma初创企业 [+2]

原研机构

Institut des Biomolécules Max Mousseron

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Institut des Biomolécules Max Mousseron 相关的临床结果

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0 项与 Institut des Biomolécules Max Mousseron 相关的专利（医药）

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365

项与 Institut des Biomolécules Max Mousseron 相关的文献（医药）

2024-07-03·ACS Applied Materials & Interfaces

Rigid Cyclic Fluorinated Detergents: Fine-Tuning the Hydrophilic–Lipophilic Balance Controls Self-Assembling and Biochemical Properties

Article

作者: Keller, Sandro ; Soulié, Marine ; Chantemargue, Benjamin ; Bouchemal, Ilham ; Petit-Härtlein, Isabelle ; Fieschi, Franck ; Deletraz, Anais ; Wehbie, Moheddine ; Mahler, Florian ; Le Roy, Aline ; Ebel, Christine ; Durand, Grégory ; Breyton, Cécile

We report herein the synthesis of three detergents bearing a perfluorinated cyclohexyl group connected through a short, hydrogenated spacer (i.e., propyl, butyl, or pentyl) to a β-maltoside polar head that are, respectively, called FCymal-3, FCymal-4, and FCymal-5. Increasing the length of the spacer decreased the critical micellar concentration (CMC), as demonstrated by surface tension (SFT) and isothermal titration calorimetry (ITC), from 5 mM for FCymal-3 to 0.7 mM for FCymal-5. The morphology of the micelles was studied by dynamic light scattering (DLS), analytical ultracentrifugation (AUC), and small-angle X-ray scattering (SAXS), indicating heterogeneous rod-like shapes. While micelles of FCymal-3 and -4 have similar hydrodynamic diameters of ∼10 nm, those of FCymal-5 were twice as large. We also investigated the ability of the detergents to solubilize lipid membranes made of 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine (POPC). Molecular modeling indicated that the FCymal detergents generate disorder in lipid bilayers, with FCymal-3 being inserted more deeply into bilayers than FCymal-4 and -5. This was experimentally confirmed using POPC vesicles that were completely solubilized within 2 h with FCymal-3, whereas FCymal-5 required >8 h. A similar trend was noticed for the direct extraction of membrane proteins from E. coli membranes, with FCymal-3 being more potent than FCymal-5. An opposite trend was observed in terms of stabilization of the two model membrane proteins bacteriorhodopsin (bR) and SpNOX. In all three FCymal detergents, bR was stable for at least 2 months with no signs of aggregation. However, while the structural integrity of bR was fully preserved in FCymal-4 and -5, minor bleaching was observed in FCymal-3. Similarly, SpNOX exhibited the least activity in FCymal-3 and the highest activity in FCymal-5. By combining solubilizing and stabilizing potency, FCymal detergents push forward our expectations of the usefulness of fluorinated detergents for handling and investigating membrane proteins.

2024-03-23·Journal of Molluscan Studies

Description of the feeding rhythm of cone snails in French Polynesia

作者: Planes, Serge ; Bambridge, Tamatoa ; Dutertre, Sebastien ; Teillard, Valentin ; Salvat, Bernard ; Gache, Camille

ABSTRACTThe Conidae is a family of marine gastropod molluscs that includes carnivorous and venomous species. The venom they produce is remarkably diverse and has recently drawn much interest from a pharmacological perspective. To respond to this growing interest, a better understanding of the ecology and biology of the species is required. Only a few studies have examined the feeding behaviour and the trophic specialization of these species in detail. In this study, we investigated diet through hunger and satiety experiments of eight species of cones that occur in French Polynesia and that present different feeding modes (piscivorous, molluscivorous or vermivorous). Monitoring behaviour of cones during fasting periods demonstrated a correlation between increased hunger and nocturnal cone activity, mainly for piscivorous species, while the molluscivores did not show this correlation. In the study on satiety, we defined an average frequency of feeding for cone species that were fed prey ad libitum. Finally, this study provided indications that will help to define an equilibrium feeding frequency in further studies involving the cultivation of cones.

2024-03-22·ACS Applied Polymer Materials

Surfmer versus Polymer Effect toward Solubilization and Stabilization of Membrane Proteins

作者: Soulié, Marine ; Mangin, Floriane ; Chauhan, Vinay ; Guillet, Pierre ; Banères, Jean-Louis ; Damian, Marjorie ; Durand, Grégory

We have synthesized four acrylamide-based monomers whose polar headgroup consists of one or two glucose or one maltose moieties and whose alkyl chain is made of a n-decyl or a n-octyl hydrophobic chain.These surface-active monomers, called surfmers, were polymerized by free-radical telomerization in the presence of a thiol-based transfer agent, leading to four new nonionic polymers that belong to the class of amphipols.A very good reproducibility and control of the polymerization was noted, leading to average polymerization degrees in perfect agreement with the initial ratio R0 and to quite a narrow polydispersity index after purificationSurface tension (SFT) measurements indicate that the four surfmers self-assemble at concentrations ranging from ∼0.5 to 4 mM.Dynamic light scattering (DLS) experiments suggest the formation of rather small homogeneous aggregates of 5 nm diameter for the monomers, while the size of the aggregates ranges from 5 to 16 nm diameter for the polymers.The ghrelin receptor GHSR, a typical rhodopsin-like G protein-coupled receptor (GPCR), was used as a challenging model because of its conformational instability in vitro.The surfmers solubilized the receptor from membrane fractions more efficiently than their polymeric counterparts.In contrast, the polymers were significantly more efficient at stabilizing the functional fold of the isolated protein in solutionThis demonstrates the opposite effect of surfmers and their polymer counterparts toward the solubilization and stabilization of a fragile membrane protein.

100 项与 Institut des Biomolécules Max Mousseron 相关的药物交易

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100 项与 Institut des Biomolécules Max Mousseron 相关的转化医学

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