Objective: To verify the feasibility and reliability of the pilot process of irbesartan and hydrochlorothiazide tablets.Methods: Three batches of the tablets were produced according to the determined formula and process, and the key parameters in the pilot production were verified.Results: All the indexes for each batch of irbesartan and hydrochlorothiazide tablets conformed to the requirements of the quality standardConclusion: The pilot process of irbesartan and hydrochlorothiazide tablets is feasible, and the technol. process and parameters can ensure the product quality with promising reliability and stability.