Tempero Bio, Inc.

Tokyo, Japan and Cambridge, UK, 13 February 2024 – Sosei Group Corporation (“Sosei Heptares” or “the Company”; TSE: 4565) provides an update on operational activities and reports its consolidated results for the 12 months ended 31 December 2023. The full report can be found by clicking here. Chris Cargill, President & CEO of Sosei Heptares, commented: “2023 has been a transformational year for Sosei Group and the progress made by our teams across all areas of the business has been exceptional. This progress is enabling the Group to accelerate its development in 2024 as an integrated, technology powered, commercial-stage biopharmaceutical company focused on cutting-edge science and delivering life-changing medicines for patients in Japan and globally. “We continue to accelerate business integration following the acquisition of Idorsia Pharmaceuticals Japan Ltd (“IPJ”) and Idorsia Pharmaceuticals Korea Co., Ltd (“IPK”), which has brought an exciting new dimension to our Group including the potential for many strategic development and commercial opportunities. We embark on this next phase of our journey as a well-financed organization and with a clear vision to create value for all our stakeholders and I want to thank all our employees for their efforts in making this a reality.” Operational Highlights for Q4 2023 Landmark investment of ~JPY8 billion (~USD54m) into Sosei Group from new OPF1 fund operated by JIC Venture Growth Investments Co., Ltd., an affiliate of Japan Investment Corporation – in conjunction with a share offering and convertible bond restructuring to finance the Group’s strategic growth initiatives; to extend the maturity pro its debt; and further strengthen its financial base. Marketing approval for PIVLAZ® in South Korea – for the prevention of cerebral vasospasm and related conditions after aneurysmal subarachnoid hemorrhage (“aSAH”) securing. New Drug Application submitted in Japan for the approval of daridorexant, a novel dual orexin receptor antagonist, for the treatment of adult patients with insomnia – in relation to the submission, the Group received JPY 1.5 billion, which has been recognized as revenue in Q4 2023. Partner Neurocrine confirmed its plans to evaluate two new muscarinic agonist candidates in Phase 1 studies – both NBI-1117569 (a muscarinic M4-preferring agonist) and NBI-1117567 (a muscarinic M1-preferring agonist) are oral compounds that may have the potential to treat neurological and neuropsychiatric conditions. A Phase 1 study of NBI-1117569 has begun and a Phase 1 study of NBI-1117567 is expected to begin in 2024. Partner Pfizer entered a new oral small molecule GLP-1 receptor agonist into a Phase 1 clinical trial targeting metabolic diseases – PF-06954522 was discovered by Pfizer scientists during a multi-target research collaboration in which Pfizer had access to Sosei Heptares’ StaR® technology. Discussions underway with GSK to regain full ownership of GSK43814061, a clinic-ready, first-in-class, oral GPR35 agonist targeting Inflammatory Bowel Diseases (“IBD”) – upon regaining ownership, the Group expects to proceed with a planned UK Phase 1 trial of GSK43814061 while determining the optimal strategy for the further clinical development and/or re-partnering of the program. US$3.75 million milestone payment received from partner Genentech – the discovery-based payment is related to progression of a potential first-in-class project targeting an undisclosed GPCR. Genentech will now be responsible for further development and commercialization of this potential new medicine. Strong progress in collaborations with leading technology companies Kallyope – identification, validation and nomination of a first GPCR target to enter a therapeutic discovery program for gastrointestinal diseases, Verily – launching a new discovery program based on the successful validation and nomination of a GPCR target for immune-mediated diseases with an initial indication focus of IBD, and PharmEnable Therapeutics – expansion of a collaboration to drive discovery of novel small molecule drug candidates against a second neurological disease target. Operational Highlights for Full Year 2023 Transformational acquisition of Idorsia’s pharmaceutical business in Japan and APAC – achieves key strategic milestone to become a fully integrated biopharmaceutical company: Adds complementary late-stage clinical development capability with profitable and fast-growing commercial operations in Japan. Brings highly experienced team, with proven clinical development and commercial launch track record. Lean, go-to-market commercial model, well positioned to scale rapidly to generate significant value from Japan and APAC geographic expansion. Includes Japan and APAC (ex-China) rights to two medicines with significant growth potential (PIVLAZ®) and daridorexant, as well as exclusive options and selected rights to up to seven other products from Idorsia’s clinical development pipeline. Purchase price of JPY65 billion is fully funded from existing cash (JPY25 billion) and new JPY40 billion long-term, low-rate corporate loan. First subject dosed with wholly owned HTL0048149 in Phase 1 trial – HTL’149 is a first-in-class GPR52 agonist designed by the Company as a once-daily oral treatment to address positive and negative symptoms and cognitive impairment in schizophrenia patients without the adverse effects typically associated with existing antipsychotic drugs. First patient dosed with cancer immunotherapy candidate HTL0039732in Phase 1/2a trial – HTL’732 is an orally available small molecule EP4 antagonist for advanced solid tumors being evaluated under an agreement with Cancer Research UK. Partner Neurocrine Biosciences initiated Phase 1 clinical study with NBI-1117570 – an investigational, oral, muscarinic M1/M4 selective dual agonist that may have the potential to treat neurological and neuropsychiatric conditions. Partner Tempero Bio received FDA clearance to advance clinical development of TMP-301 for alcohol and substance use disorders – TMP-301 (formerly HTL0014242) is a selective, orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero Bio. Sosei Group’s share listing elevated to the Tokyo Stock Exchange Prime Market – shortly after, Sosei Group shares were included in the Tokyo Stock Price Index (TOPIX). Changes to Board and Executive Management team – Ms. Eiko Tomita, a highly experienced pharmaceutical executive, was elected as an Independent External Director. Ms. Candelle Chong was promoted to Executive Vice President and Chief of Staff. Post-period Highlights Appointment of Chief Operating Officer – Mr. Toshihiro Maeda was appointed to this newly created role at Sosei Heptares to lead the post-acquisition integration of IPJ, and global technical operations, including manufacturing, supply chain and quality assurance, for the enlarged business in Japan and the Asia-Pacific region. Financial Highlights Revenue totalled JPY 12,766 million (US$90.8 million*), a decrease of JPY 2,803 million (US$27.7 million) vs. the prior corresponding period. The decrease is primarily due to the decrease in revenue related to upfront fees and milestone income due to signing no new partnership agreements and the occurrence of four milestone events in the current period vs. two upfront fee and five milestone events in the prior corresponding period, partially offset by the increase in pharmaceutical product sales due to the inclusion of IPJ in the scope of consolidation in July 2023, which resulted in the addition of PIVLAZ® sales. R&D expenses totalled JPY 10,075 million (US$71.7 million), an increase of JPY 2,621 million (US$14.9 million) vs. the prior corresponding period. This increase reflects an increased investment in discovery activities, but also reflects the impact of the weaker Yen. JPY 881 million (US$6.3 million) has been included for R&D expenses relating to IPJ and IPK. G&A expenses totalled JPY 9,965 million (US$70.9 million), an increase of JPY 5,588 million (US$37.6 million) vs. the prior corresponding period. This increase is primarily due to the inclusion of non-recurring M&A related costs. JPY 3,755 million (US$26.7 million) has been included for G&A expenses relating to IPJ/IPK. Operating loss totalled JPY 9,526 million (US$67.8 million) vs. an operating profit of JPY 3,436 million (US$26.2 million) in the prior corresponding period. This increase reflects the combined effect of all the movements explained above. Loss before income tax totalled JPY 10,680 million (US$76.0 million) vs. a profit before income tax of JPY 1,078 million (US$8.2 million) in the prior corresponding period. This increase reflects the combined effect of all the movements explained above. Net loss for the year ended 31 December 2023 totalled JPY 7,193 million (US$51.2 million) vs. a net profit of JPY 382 million (US$2.9 million) in the prior corresponding period. This increase reflects the combined effect of all the movements explained above. Core operating loss** totalled JPY 3,076 million (US$21.9 million) vs. a core operating profit of JPY 5,856 million (US$44.6 million) in the prior corresponding period. Cash and cash equivalents as at 31 December 2023 amounted to JPY 49,065 million (US$347.9 million) having decreased by JPY 17,492 million (US$159.1 million) from the beginning of the year. This decrease was primarily due to the transaction with Idorsia. *Convenience conversion to US$ at the following rates: FY 2023: 1US$ =140.53 JPY; FY 2022: 1US$ =131.30 JPY; 31 Dec 2023: 1US$ = 141.03 JPY; 31 Dec 2022: 1US$ = 131.27 JPY **Core operating profit / loss is an alternative performance measure which adjusts for material non-cash costs and one-off costs in order to provide insights into the recurring cash generation capability of the core business. -ENDS- About Sosei Heptares Sosei Heptares is a fully integrated biopharmaceutical company focused on bringing life-changing medicines based on world-class science to patients globally. Our vision is to become one of Japan’s global biopharmaceutical champions. Our global business combines our world-leading GPCR-targeted StaR® technology, structure-based drug design and early development capabilities in the UK with a highly experienced clinical development capability and a commercial operation in Japan. We are leveraging these capabilities to generate and advance a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology and inflammatory diseases. We intend to develop these opportunities for patients in Japan and globally both internally and through our partnerships with global biopharmaceutical companies and emerging technology companies. Sosei Heptares operates from key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea). “Sosei Heptares” is the corporate brand and trademark of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565). Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies. For more information, please visit LinkedIn: @soseiheptaresco | X: @soseiheptaresco | YouTube: @soseiheptaresco Enquiries: Sosei Heptares – Media and Investor Relations Kentaro Tahara, VP Investor Relations and Corporate Strategy Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures Maya Bennison, Communications Manager +81 (0)3 5210 3399 | +44 (0)1223 949390 | IR@SoseiHeptares.com MEDiSTRAVA Consulting (for International Media) Mark Swallow, Frazer Hall, Erica Hollingsworth +44 (0)203 928 6900 | SoseiHeptares@medistrava.com Forward-looking statements This press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Sosei Group Corporation’s actual results to differ materially from those expressed or implied by the forward-looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Attachment FY23YE_Tanshin_ Sosei Heptares

Tokyo, Japan and Cambridge, UK, 4 August 2023 – Sosei Group Corporation (“the Company”; TSE: 4565) provides an update on operational activities and reports its consolidated results for the second quarter and first half ended 30 June 2023. The full report can be found by clicking here. Chris Cargill, President & CEO of Sosei Heptares, commented: “We begin the second half of 2023 as a much enlarged, transformed and energized organization with a clear strategy for success, following the completion of the fully funded acquisition of Idorsia’s pharmaceutical business in Japan and Asia-Pacific (ex-China). “We are confident that the addition of this business – bringing an experienced team with extensive development capabilities and commercial expertise, along with selected product rights that include PIVLAZ®, an approved and fast-growing product, and daridorexant, for which J-NDA filing is expected in 2H 2023 – creates the ideal platform to deliver our revenue and growth goals in Japan and Asia-Pacific (ex-China). “The acquired operation is also highly complementary to our world-leading GPCR-targeted discovery and early development business in the UK, allowing us to become a fully integrated organization, with the broad capabilities, expanded pipeline and lean and agile business model, capable of taking drugs from discovery to patients in Japan while opening new partnering opportunities globally. “Our immediate focus is to integrate the businesses to ensure continued operational efficiency so that we can progress our expanded internal discovery and development programs, support our multiple partnered programs, and develop our commercial activities in Asia-Pacific (ex-China). “We are confident that this integration will result in Sosei Heptares being well positioned to achieve its goal of becoming a new and dynamic leader in the Japanese biopharma industry, delivering life-changing medicines to patients globally and allowing us to create significant value to all our key stakeholders.” Operational Highlights for H1 2023 On 15 March 2023, Sosei Group’s share listing was elevated to the Prime Market segment of the Tokyo Stock Exchange from the Growth Market segment – Further, on 27 April 2023, Sosei Group shares were included in the Tokyo Stock Price Index (TOPIX), an important stock market index that tracks all domestic companies mainly on the Prime market segment.Sosei Heptares’ partner, Tempero Bio, received FDA clearance to advance clinical development of TMP-301 for alcohol and substance use disorders (January) – TMP-301 (formerly HTL0014242) is a selective, orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero.Centessa Pharmaceuticals nominated ORX750 as its product candidate with potential to be a best-in-class therapy for narcolepsy and other sleep disorders (March) – ORX750 is an orally administered, selective orexin receptor-2 (OX2R) agonist developed using Sosei Heptares’ platform, and currently in preclinical development and undergoing IND-enabling activities.Pfizer announced its decision to prioritize the development of danuglipron over lotiglipron for the treatment of diabetes and obesity (June) – as a result, Pfizer discontinued the development of lotiglipron, a novel and orally available GLP-1 receptor agonist discovered and developed by Pfizer during a multi-target research collaboration with Sosei Heptares. Sosei Heptares will explore next steps with Pfizer for the future development of lotiglipron.Changes to the Board and Executive Management Team (March) – Eiko Tomita (VP, Global Regulatory Affairs at Bristol Myers Squibb) was elected to the Board of Directors and Candelle Chong was promoted to EVP and Chief of Staff (previously Senior Vice President, Corporate Strategy) at the Annual Shareholder’s Meeting and the subsequent Board of Directors meeting held on 23 March 2023. Post-period Events Transformational acquisition of Idorsia’s pharmaceutical business in Japan and APAC (ex-China) (July) – achieves key strategic milestone to become a fully integrated biopharmaceutical company: Adds complementary late-stage clinical development capability with profitable and fast-growing commercial operations in Japan.Brings highly experienced team, with proven clinical development and commercial launch track record, led by Dr. Satoshi Tanaka.Lean, go-to-market commercial model, well positioned to scale rapidly to generate significant value from Japan and APAC (ex-China) geographic expansion.Includes Japan and APAC (ex-China) rights to two life-changing medicines with significant growth potential (PIVLAZ® – approved for cerebral vasospasm, and daridorexant – Japan filing expected in 2H 2023 for insomnia) and exclusive options and selected rights to up to seven other products from Idorsia’s clinical development pipeline.Purchase price of JPY65 billion is fully funded from existing cash (JPY25 million) and new JPY40 million long-term, low-rate corporate loan from Mizuho Bank.Transaction is expected to be cash-flow positive in first full calendar year. First subject dosed with HTL0048149 in Phase 1 Trial – HTL’149 is a first-in-class GPR52 agonist designed by the Company as a once-daily oral treatment to address positive and negative symptoms and cognitive impairment in schizophrenia patients without the adverse effects typically associated with existing antipsychotic drugs. Note regarding the Idorsia transaction: the Group’s recent transaction with Idorsia Limited occurred after the 30 June 2023 balance sheet date, and therefore the forthcoming quarterly period ending 30 September 2023 (Q3 2023) will be the first period in which the Group consolidates the financial results of Idorsia’s former Japanese business. For reference, on 25 July 2023, Idorsia Limited reported net sales of PIVLAZ® in Japan for the six-month period ended 30 June 2023 of CHF32 million, an increase of CHF21 million (or +184%) vs. the prior corresponding period. As a result of the transaction, the Group’s pro forma Cash and Cash Equivalents as at 31 July 2023 amounted to JPY 43,507 million (US$309 million), having decreased by JPY 22,091 million (US$156 million) from 30 June 2023 as a result of partially funding the transaction. Financial Highlights for the Six-month Period ended 30 June 2023 Revenue totalled JPY 2,146 million (US$15.9 million*), a decrease of JPY 311 million (US$4.1 million) vs. the prior corresponding period. The decrease is primarily due to the decrease in revenue related to royalties and other revenue, partially offset by the increase in revenue related to upfront fees and milestone income due to larger releases of deferred revenue.R&D expenses totalled JPY 4,039 million (US$30.0 million), an increase of JPY 341 million (a decrease of US$0.1 million) vs. the prior corresponding period. This increase reflects an increased investment in discovery activities, but also reflects the impact of the weaker Yen.G&A expenses totalled JPY 2,571 million (US$19.1 million), an increase of JPY 306 million (US$0.6 million) vs. the prior corresponding period. This was primarily due to professional advisory fees relating to the acquisition of Idorsia Limited’s pharmaceuticals business in Japan and APAC (ex-China), which completed on July 20, 2023.Operating loss totalled JPY 4,168 million (US$30.9 million) vs. an operating loss of JPY 3,804 million (US$31.0 million) in the prior corresponding period. This increase reflects the combined effect of all of the movements explained above.Loss before income tax totalled JPY 3,760 million (US$27.9 million) vs. a loss before income tax of JPY 4,282 million (US$34.9 million) in the prior corresponding period. This decrease reflects the combined effect of all of the movements explained above, together with higher interest income (as a result of higher UK interest rates) and a reduction in cost relating to the cessation of equity accounting for the Group’s investment in MiNA.Net loss for the six-month period ended 30 June 2023 totalled JPY 2,060 million (US$15.3 million) vs. a net loss of JPY 3,538 million (US$28.8 million) in the prior corresponding period. This decrease reflects the combined effect of all of the movements explained above combined with a higher income tax benefit.Core operating loss** totalled JPY 2,720 million (US$20.2 million) vs. a core operating loss of JPY 2,378 million (US$19.4 million) in the prior corresponding period.Cash and cash equivalents as at 30 June 2023 amounted to JPY 65,598 million (US$453.1 million) having decreased by JPY 959 million (US$53.9 million) from the beginning of the year. *Convenience conversion to US$ at the following rates: FY 2023: 1US$ =134.82 JPY; FY 2022: 1US$ =122.83 JPY; 30 Jun 2023: 1US$ = 144.78 JPY; 31 Dec 2022: 1US$ = 131.27 JPY ** Core operating profit / loss is an alternative performance measure which adjusts for material non-cash costs and one-off costs in order to provide insights into the recurring cash generation capability of the core business. -ENDS- About Sosei HeptaresSosei Heptares is a fully integrated biopharmaceutical company focused on bringing life-changing medicines based on world-class science to patients globally. Our vision is to become one of Japan’s global biopharmaceutical champions. Sosei Heptares has a leading development capability and a profitable and growing commercial operation in Japan, which it intends to expand into additional selected markets in the Asia-Pacific region. Sosei Heptares is advancing a broad and deep pipeline of novel medicines created using its world-leading GPCR-targeted StaR® technology and structure-based drug design platform across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammatory diseases. In addition, we have leveraged our unique discovery and development capabilities to establish multiple value-generating partnerships with world-leading biopharmaceutical companies, including AbbVie, Genentech (Roche), GSK, Lilly, Neurocrine Biosciences, Novartis, Pfizer, Sanofi and Takeda. Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in London and Cambridge, UK. “Sosei Heptares” is the corporate brand and trademark of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565). Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies. For more information, please visit https://soseiheptares.com/LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco Enquiries Sosei Heptares – Media and Investor RelationsHironoshin Nomura, Chief Financial Officer Shinichiro Nishishita, VP Investor Relations, Head of Regulatory DisclosuresMaya Bennison, Communications Manager+81 (0)3 5210 3399 | +44 (0)1223 949390 | IR@SoseiHeptares.com MEDiSTRAVA Consulting (for International Media)Mark Swallow, Frazer Hall+44 (0)203 928 6900 | SoseiHeptares@medistrava.com Forward-looking statementsThis press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Sosei Group Corporation’s actual results to differ materially from those expressed or implied by the forward-looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Attachments Sosei Group FY23Q2 E_Tanshin_230804_Final Sosei Group FY23Q2 1H Results Presentation_Final

Tokyo, Japan and Cambridge, UK, 12 May2023 – Sosei Group Corporation (“the Company”; TSE: 4565) provides an update on operational activities and reports its consolidated results for the first quarter ended 31 March 2023. The full report can be found here. Chris Cargill, President & CEO of Sosei Heptares, commented: “We are continuing to make good progress in building the foundation Sosei Heptares needs to become a leading international biopharmaceutical company headquartered in Japan by 2030. “A key milestone in that journey was the elevation of our shares to the TSE Prime Market from the Growth Market and our inclusion in the TOPIX index. We are confident that this will improve our ability to attract an increasing number of institutional investors who are familiar with the biotech industry, hold a long-term perspective and can support the acceleration of our growth driven by the core strategy we unveiled and began executing last year. This strategy is focused on (1) enhancing our platform; (2) progressing our partnerships; (3) transforming our R&D; and (4) commercializing products in Japan. “From a corporate perspective, we have also made great progress in establishing our ESG priorities and published these in our inaugural ESG report. We are working hard to embed these objectives into our business operations as well as our culture and values. “I am very proud of what our team members in Japan and in the UK have accomplished so far in 2023 and look forward to the start of first-in-human trials for two of our inhouse programs and further progress across our extensive portfolio over the rest of the year.” Operational Highlights for Q1 2023 On 15 March 2023, Sosei Group’s share listing was elevated to the Prime Market segment of the Tokyo Stock Exchange from the Growth Market segment - Further, on 27 April 2023, Sosei Group shares were included in the Tokyo Stock Price Index (TOPIX), an important stock market index that tracks all domestic companies mainly on the Prime market segment. Publication of inaugural ESG report – The Report describes the Company’s efforts to prioritize, address and measure its progress on a range of Environmental, Social and Governance (ESG) objectives determined to make a positive impact on its employees, the wider community in which it operates, and the environment. Sosei Heptares’ partner, Tempero Bio, received FDA clearance to advance clinical development of TMP-301 for alcohol and substance use disorders – TMP-301 (formerly HTL0014242) is a selective, orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero Bio. Centessa Pharmaceuticals nominated ORX750 as its product candidate with potential to be a best-in-class therapy for narcolepsy and other sleep disorders – ORX750 is an orally administered, selective orexin receptor-2 (OX2R) agonist developed using Sosei Heptares’ platform, and currently in preclinical development and undergoing IND-enabling activities. Changes to the Board and Executive Management Team – Eiko Tomita (VP, Global Regulatory Affairs at Bristol Myers Squibb) was elected to the Board of Directors and Candelle Chong was promoted to EVP and Chief of Staff (previously Senior Vice President, Corporate Strategy) at the Annual Shareholder’s Meeting and the subsequent Board of Directors meeting held on 23 March 2023. Financial Highlights for the Three-month Period ended 31 March 2023 Revenue totalled JPY 943 million (US$7.1 million*), a decrease of JPY 176 million (US$2.5 million) vs. the prior corresponding period. The decrease is primarily due to the decrease in revenue related to royalties and other revenue, partially offset by the increase in revenue related to upfront fees and milestone income due to larger releases of deferred revenue. R&D expenses totalled JPY 1,957 million (US$14.8 million), an increase of JPY 153 million (a decrease of US$0.7 million) vs. the prior corresponding period. The increase is primarily due to increased investment in discovery activities, but also reflects the impact of the weaker Yen. G&A expenses totalled JPY 1,109 million (US$8.4 million), a decrease of JPY 245 million (US$3.3 million) vs. the prior corresponding period. This was primarily due to a decrease in restructuring costs. Operating loss totalled JPY 1,964 million (US$14.8 million) vs. operating loss of JPY 2,206 million (US$19.0 million) in the prior corresponding period. This decrease was primarily due to a reduction in G&A expenses and cost of sales, as well as an increase in net other income. Net loss before income tax totalled JPY 1,863 million (US$14.1 million) vs. a net loss before income tax of JPY 2,497 million (US$21.5 million) in the prior corresponding period. This decrease reflects the combined effect of all of the movements explained above. Net loss for the 3-month period ended 31 March 2023 totalled JPY 1,402 million (US$10.6 million) vs. net loss of JPY 2,070 million (US$17.8 million) in the prior corresponding period This decrease reflects the combined effect of all of the movements explained above. Core operating loss** totalled JPY 1,465 million (US$11.1 million) vs. core operating loss of JPY 1,240 million (US$10.7 million) in the prior corresponding period. Cash and cash equivalents as at 31 March 2023 amounted to JPY 66,138 million (US$498.5 million) having decreased by JPY 419 million (US$8.5 million) from the beginning of the year. *Convenience conversion to US$ at the following rates: FY 2023: 1US$ =132.32 JPY; FY 2022: 1US$ =116.19 JPY; 31Mar 2023: 1US$ = 132.68 JPY; 31 Dec 2022: 1US$ = 131.27 JPY **Core operating profit / loss is an alternative performance measure which adjusts for material non-cash costs and one-off costs in order to provide insights into the recurring cash generation capability of the core business. -ENDS- About Sosei Heptares We are an international biopharmaceutical group focused on the discovery and early development of new medicines originating from our proprietary GPCR-targeted StaR® technology and structure-based drug design platform capabilities. We are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammatory diseases. We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca, Genentech (Roche), GSK, Kallyope, Lilly, Neurocrine Biosciences, Novartis, Pfizer, Takeda and Verily. Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in Cambridge, UK. “Sosei Heptares” is the corporate brand and trademark of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565). Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies. For more information, please visit LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco Enquiries: Sosei Heptares – Media and Investor Relations Japan Hironoshin Nomura, Chief Financial Officer Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures +81 (0)3 5210 3399 UK Candelle Chong, Chief of Staff Maya Bennison, Communications Manager +44 (0)1223 949390 IR@SoseiHeptares.com MEDiSTRAVA Consulting (for International Media) Mark Swallow, Frazer Hall, Eleanor Perkin +44 (0)203 928 6900 | SoseiHeptares@medistrava.com Forward-looking statements This press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Sosei Group Corporation’s actual results to differ materially from those expressed or implied by the forward-looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.