The goal of this clinical trial is to test whether a single-session Acceptance and Commitment Therapy (ACT) videogame (ACTing Minds) improves psychological flexibility and mental health in adults who report mild to moderate depression, anxiety or stress. The main questions are whether ACTing Minds increases psychological flexibility (CompACT Total) more than a time- and engagement-matched neutral commercial game at the end of the session and again about three weeks later, and whether it produces favourable changes in symptoms, wellbeing, social connectedness, health-related quality of life, and short seated heart-rate variability recordings. Researchers will compare ACTing Minds with the neutral game to determine whether the ACT-based experience leads to greater improvements. Participants attend one laboratory visit of about 60 minutes, complete brief questionnaires at baseline, immediately after the session and at a three-week follow-up, and provide a short seated ECG at each timepoint for heart-rate variability analysis. The study uses a single-blind, two-arm, randomised, parallel-group design at Swansea University (UK).

开始日期2025-12-01

申办/合作机构

Swansea University

ISRCTN13306346

/ Recruiting临床4期IIT

What works to improve SafeTy, pAtient experience, outcomes and costs related to deLayed ambulance handovers at Emergency Departments? A whole systems approach

开始日期2025-08-01

申办/合作机构

Swansea University

NCT06961513

/ Not yet recruitingN/AIIT

Patient-reported Outcomes and Views of Treatments for Pelvic-floor Muscle Dysfunction, and Their Relationship to Patient Psycho-social Characteristics.

Pelvic-floor muscle dysfunction (PFMD) affects 25% of women. It involves urinary and faecal incontinence, prolapse, sexual dysfunction, pelvic pain, and is associated with psycho-social issues (depression, anxiety), impacting negatively quality-of-life. First-line treatment for PFMD is women's health physiotherapy, which is safe, patient acceptable, and clinically effective. However, its effectiveness can be compromised by patient nonattendance/nonengagement, which can result in worsening of condition necessitating later surgery. The current research assesses factors contributing to outcomes, and nonattendance/nonengagement, so this knowledge may help improve healthcare system support and delivery. A range of routinely-collected factors at intake (physical functioning, psychological functioning, and demographic-social characteristics) will be related to routinely-gathered outcomes (patient-rated improvement in function; attendance and engagement). Additionally, a subset of patients who either attended or did not attend appointments, will be interviewed about their reasons for attendance/nonattendance. The aims are to determine: (1) whether any patient factors predict outcomes (functioning, attendance/engagement); (2) whether clusters of intake-factors differentiate patients who did/did not attended; and (3) patient views on why they attended or did not. Consecutively referred women with PFMD at the Women's Health Unit, Singleton Hospital, Swansea, will be asked for informed consent to participate. Following consent, routine assessment height, weight, age, diagnosis any physical measures of pelvic floor functioning will be taken, collected by medical staff. Questionnaires on patient-reported measures of pelvic-function, general health, quality of life, and psychological state will be completed, which should take 30min to complete. Patients will then have physiotherapy treatment, as usual. At discharge, the same data will be obtained. A subset of patients (N=80) will be contacted following initial appointment; half who attended, and half who did not. Following their consent to a telephone interview concerning their thoughts on the healthcare offered, and reasons they did/did not attend. This interview will be conducted, recorded anonymously, and analysed.

开始日期2025-04-29

申办/合作机构

Swansea University

100 项与 Swansea University 相关的临床结果

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0 项与 Swansea University 相关的专利（医药）

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10,296

项与 Swansea University 相关的文献（医药）

2026-05-01·COGNITION

Facial expression recognition in the broader autism phenotype: What does alexithymia have to do with it?

Article

作者: Castle, E ; Tree, J J ; Donnelley, S ; Fletcher-Miles, H ; Childs, M ; Towler, J R ; Reinert-Joensen, T ; Soupioni, C ; Kannan, C ; Brooks, D

Emotion recognition difficulties are widely reported in autism, but the "alexithymia hypothesis" proposes that such deficits are driven by co-occurring alexithymic traits rather than autism itself. We tested this hypothesis in a large sample of 556 adults spanning the broader autism phenotype, using self-reported autistic traits (Autism Quotient, AQ), alexithymia (Toronto Alexithymia Scale, TAS-20), and multiple face processing tasks. All participants completed an emotional expression discrimination task; Subsample 1 (N = 231) additionally completed an expression labelling task and Raven's matrices, while Subsample 2 (N = 325) completed the Cambridge Face Memory Test. Across correlational, regression, partial correlation, and mediation analyses, autistic traits-particularly social-communicative difficulties-were the strongest and most consistent predictors of poorer emotion recognition. In contrast, the core alexithymia facets of difficulty identifying and describing feelings did not contribute unique variance once autistic traits were controlled. Importantly, externally oriented thinking (EOT) emerged as the only alexithymia facet with independent predictive value, consistently associated with reduced accuracy across both emotional and identity face recognition tasks. This suggests that EOT reflects a broader domain-general attentional style that deprioritises reflective engagement with socially salient information. Group-based analyses further confirmed that high autistic trait groups showed significant recognition impairments regardless of alexithymia levels. These findings challenge the alexithymia hypothesis and highlight autistic traits as primary drivers of emotion recognition difficulties, with EOT adding an additional, qualitatively distinct influence. The results call for revised multivariate models of face and emotion processing that integrate autistic traits, attentional orientations, cognitive ability, and gender.

2026-03-01·MARINE POLLUTION BULLETIN

Topographic and biogenic complexity drive the spatio-temporal formation of microclimate on intertidal eco-engineered seawalls

Article

作者: Foggo, Andy ; Griffin, John N ; Knights, Antony M ; Bauer, Franz ; Hanley, Mick E ; Firth, Louise B ; Brown, Austin

Coastal substratum topography shapes microhabitat conditions both directly, by modulating abiotic environmental factors, and indirectly, by influencing the establishment of topography-associated biota. Consequently, structural differences between natural rocky shores and modern engineered coastal infrastructure are expected to alter microhabitat formation in urban seascapes, by reshaping interactions between topography, abiotic conditions, and biogenic habitat structure. Here, we tracked the development of microclimate conditions (temperature, light, humidity) across 12 months on three eco-engineered panel designs installed on an intertidal seawall. Abiotic factors were assessed at both the panel scale, and at the scale of specific topographic features (outer surfaces, plateaus, overhangs, crevices). Effects of biological colonisation (i.e., canopy cover) were disentangled from direct topographic effects by assessing bare, temporarily installed reference panels at each timepoint. Structurally complex panels exhibited lower mean temperatures, and a greater range of light and humidity conditions than flat panels. Inner topographic features, such as crevices and overhangs, reduced temperatures and light intensities, and increased humidity compared to outer surfaces. Macroalgal canopy formation further reduced most temperature and light parameters, while elevating humidity. These effects occurred irrespective of topography; however, complex panels exhibited cumulative topographic-biogenic effects that created unique microenvironmental conditions not found on flat, colonized panels. Our findings provide quantitative, mechanistic insights into how engineered habitat complexity drives fine-scale microclimate patterns, with practical applications for designing multifunctional, ecologically sustainable coastal infrastructure. Restoring (micro-)habitat conditions on anthropogenically modified shorelines through biomimicry and nature-based solutions is key to enhancing habitat suitability and climate change resilience in urbanized environments.

2026-02-01·JOURNAL OF INVERTEBRATE PATHOLOGY

Are all brachyuran crabs found in the intertidal zone intermediate hosts for digenean parasites?

Article

作者: Crocker, Grace N ; Davies, Charlotte E ; Rowley, Andrew F ; Bedford, Alexander T

Digenean trematodes with complex life cycles often use marine crabs as intermediate hosts, but their distribution across crab species is not fully understood. Previous reports of Microphallus similis in edible crabs (Cancer pagurus) relied on morphological identification, leaving potential for misidentification. This study aimed to investigate the prevalence, identity, and host range of digenean parasites in intertidal brachyuran crabs from South Wales, U.K. Over six months, crabs were collected from two rocky shore sites and examined for metacercariae in the hepatopancreas. Parasites were morphologically assessed and identified by sequencing the 28S rDNA region. Metacercariae were found exclusively in juvenile C. pagurus, with ∼ 30 % prevalence and low individual burdens ranging from 1 to 69 cysts. All sequenced parasites were confirmed as M. similis. No infections were detected in Necora puber, Xantho pilipes, or X. hydrophilus. Logistic regression indicated that infection prevalence in C. pagurus varied significantly with month and crab size. This study provides the first molecular confirmation of M. similis in edible crabs from the U.K. and highlights species-specific susceptibility linked to differences in ecology and feeding behaviour. The absence of infection in co-occurring crabs suggests that C. pagurus plays a uniquely important role in the parasite's transmission cycle in intertidal environments.

项与 Swansea University 相关的新闻（医药）

2025-08-27

·taurx.com

'Keep your head down, keep working and good things will come'

Can you describe yourself in three words? I’m definitely someone who values honesty, and I was raised to always speak my mind (within reason, of course). If you’re thinking of something, there’s a good chance someone else in the room is too, but they might not have the courage to ask the question. I’ve also become quite resourceful over time. If someone’s ever unsure where to find something, I’m usually the one who can figure it out or know exactly who to ask. Lastly, I’m naturally very inquisitive. Back in school, I actually won an award for asking so many questions and my curiosity certainly hasn’t faded. Even in my 20s, I still find myself constantly asking “why” and digging a little deeper into everything. You went to Swansea University to study Medical Pharmacology. When did you first realise this was something you wanted to do? Attending university wasn't something I was entirely set on. Throughout school I always gravitated towards subjects such as maths and science as I appreciated their clarity and the fact there's usually a definitive answer, unlike more interpretive subjects. At 18 I initially applied to study Chemical Engineering and was accepted into Swansea University. However, I then spontaneously decided to take a gap year to travel across Southeast Asia and Australia. After returning to Somerset, I worked in Waitrose but soon decided I wanted to go to university. Whilst looking into my options, I noticed Swansea University had introduced a new Medical Pharmacology course, so I applied and was successful in getting in. It felt really exciting to be part of the first cohort of Medical Pharmacology students there. What drew you to a career in the life sciences sector and how did your career path lead you to TauRx? After graduating in 2021, I was eager to find a position that aligned with my degree. I thoroughly enjoyed my course, and I was excited to apply what I had learned. Not long after, I came across a job opening for a Drug Safety Specialist at ProPharma which closely mirrored the type of work I had in mind. I was involved in monitoring patients receiving the COVID vaccine, which allowed me to expand my knowledge beyond what I learned at university. An opportunity came up at TauRx, and I was especially drawn to the company’s focus on Alzheimer’s disease research - a cause close to my heart, as my great-grandmother passed away from the disease. Having witnessed its impact firsthand, the chance to contribute to research in this area felt particularly meaningful to me. Can you tell us about your role as a Pharmacovigilance Specialist at TauRx? I’m involved in a range of tasks that vary from day to day. Primarily, I oversee and help monitor studies as well as coordinate the reviews of associated plans for our studies. I’m part of the Drug Safety Oversight team, so a big part of my job is ensuring trials are conducted properly, because patient safety is at the forefront of everything we do. It’s hard to say what a typical day looks like because it does change. Each day can bring a new challenge, but I'm always confident in how I handle and adapt to these challenges! What has been the main highlight of working at TauRx so far? The fantastic team. The structure at TauRx is truly unique, I've worked in other places where you wouldn’t know the CEO's name, but at TauRx you can speak to everyone. Even though I work remotely, it feels completely seamless when I visit the office as the team is so well connected. What are your top priorities in the year ahead? One of our recent priorities has been finalising our application to the UK Medicines and Healthcare Regulatory Agency (MHRA). This has now been submitted and we’re awaiting the outcome. Within my own personal journey, I feel like I am progressing well in the company. Peer validation is nice, but I know myself that I am doing well and I’m always happy to offer more. Can you tell us the role you played in TauRx’s submission to the MHRA and a bit about what a positive outcome would mean to you? While I wasn’t directly involved in the submission, I did play a role in ensuring that the data from the Drug Safety Oversight team and the Data Science team were aligned. From a personal point of view, it would be great to get a treatment that’s been in development for over 20 years across the finish line. Knowing I contributed, even in a supporting role fills me with pride – especially as we work through the final hurdles one by one. Of course, this is a huge milestone for TauRx, as well. Seeing the progress made is exciting and it is testament to the dedication of everyone involved. What is the best professional advice you can give, or you have been given? There are three answers to this question: Can you tell us something about yourself that would be a surprise to most people? I’ve just signed up to run the Cardiff Half Marathon this October, in support of SANDS, our workplace charity. I started running at the end of March and have completed a few 10Ks since then. The half marathon will be my longest distance yet, but I’ve been sticking to a good routine of running three times a week, so I’m hopeful I’ll be ready in time. October will come round quickly, but I’m excited for the challenge! People can donate to my fundraiser here: https://cardiffhalf25.enthuse.com/pf/tom-hemmens Fun fact - I’m also ambidextrous, as I can write with both hands and kick with both feet. Naturally I’m left-handed and right footed, but I can do things with both.

2025-08-21

·生物谷

Science：血小板可捕获并储存血液中循环的DNA片段，有望改变癌症筛查

这项新的研究指出，血小板扮演着“清道夫”的角色，能够捕获并储存血液中循环的DNA片段，其中包括已确诊癌症患者体内存在的突变DNA。在一项新的研究中，来自牛津大学、爱丁堡大学与斯旺西大学的研究人员揭示了一项关于血小板的惊人新功能——这一发现有望显著推动癌症的早期检测。相关研究结果发表在《科学》杂志中。具体而言，这项新的研究指出，血小板扮演着“清道夫”的角色，能够捕获并储存血液中循环的DNA片段，其中包括已确诊癌症患者体内存在的突变DNA。当细胞死亡时，会向血液中释放遗传物质，从而引发不必要的免疫反应或其他健康问题。此前，科学家们尚未完全理解人体是如何清除这些潜在有害分子的，但该研究团队发现，血小板会主动吸收游离的DNA，帮助清洁血液并维持免疫平衡。通过简单的血液检测分析血小板DNA，研究团队甚至成功检测出癌前病变的存在，这为开发更早期、更准确且侵入性更低的癌症筛查方法铺平了道路。斯旺西大学科学与工程学院的Paul Rees教授在分析确认这一过程的显微镜数据中发挥了关键作用。Rees教授表示：“血小板的主要功能原本被认为与凝血有关，它们吸收血液中细胞游离DNA的作用完全出乎意料。此外，血小板能保护被内化的DNA免于在血液中降解，这意味着血小板DNA是检测修饰和突变的完美来源，可用于在极早期发现如癌症之类的疾病。” 血小板在循环过程中捕获和储存cfDNA 血液中循环DNA的分析正逐渐成为多种医疗场景下的重要筛查手段。然而，当前的方法丢弃血小板，只关注去除血小板后的血浆部分。该研究的第一作者、MRC Weatherall分子医学研究所（MRC WIMM）的博士后研究员Lauren Murphy博士指出：“我们的研究表明，血小板对健康的重要性可能远超我们过去的认知。这也意味着当前的液体活检筛查方法忽略了血小板中所包含的宝贵遗传信息。” 值得注意的是，团队还在孕期母亲的血小板中发现了胎儿DNA的痕迹，这为改进和完善目前的基因检测方法提供了新的可能性。牛津大学血液学副教授、该研究的资深作者Bethan Psaila博士总结道：“发现血小板扮演血液中‘DNA清道夫’的角色纯属意外。但一个幸运的推论是，血小板承载着我们体内所有组织曾发生DNA损伤的印记——对血小板的分析有望改善包括癌症在内的筛查检测。”（生物谷Bioon.com）参考文献： Lauren Murphy et al, Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA, Science (2025). DOI: 10.1126/science.adp3971.

信使RNA

2024-10-11

·Healthcare IT News

Siloam Hospitals ramp up AI integrations and more partnership briefs

Siloam collaborates on AI Siloam Hospitals in Indonesia will be adopting a range of AI solutions from Philips as part of a new partnership. The companies recently signed a memorandum of understanding, which among other things aims to deploy AI technologies across Siloam, particularly in radiology, pathology, interventional cardiology and clinical operations. Through this collaboration, the hospital network also eyes to power telemedicine, EMR, and remote patient monitoring with AI. The MOU also involves the participation of Universitas Pelita Harapan (UPH) Medical Sciences Group in developing training programmes to equip healthcare professionals, IT specialists, and medical students with the skills required to develop and implement AI in clinical settings. Moreover, Philips will share with Siloam and UPH its expertise and global practices in informatics and AI research to create scalable and tailored healthcare technology solutions. New centre on medicine AI established in Singapore The National Healthcare Group and the Nanyang Technological University have established a new research centre dedicated to healthcare AI. The Centre of AI in Medicine (C-AIM), led by NTU's Lee Kong Chian School of Medicine, aims to resolve challenges in fully adopting and integrating AI solutions in healthcare, including the lack of data verifying their effectiveness, legal and ethical considerations, and demand for proofs of AI reducing operational and manpower costs. Based on a media release, the new AI centre will focus on four areas: mental health, elderly frailty, medical imaging, and cancer screening, which aligns with Singapore’s second National AI Strategy. With over 100 researchers and clinicians onboard, C-AIM will conduct AI simulation and implementation studies with support from partners, including the Yale School of Medicine and Olympus Singapore. Singapore-UK partnership on health data science The National Research Foundation under the Singapore Prime Minister's Office will be collaborating with organisations in the United Kingdom on healthcare and data science. The agency signed a memorandum of understanding with Health Data Research UK, an independent alliance of healthcare and research organisations. They will explore opportunities to harness health data to address pressing healthcare issues and improve patient outcomes in Singapore, the UK, and other regions. Their partnership will also involve the University of Nottingham and Swansea University Medical School in the United Kingdom, as well as Singapore's Agency for Science Technology and Research and the Trusted Research and the Real-world Utilisation and Sharing Tech Office of the Ministry of Health Office for Healthcare Transformation. Apollo HealthAxis to rollout Garmin fitness trackers Apollo Hospitals' health IT subsidiary Apollo HealthAxis has entered into an initial deal with Garmin for an integrated offering. In a statement, Garmin shared that as part of this deal, its fitness trackers will be offered soon on select Apollo health plans. Meanwhile, select Garmin fitness trackers will feature access to Apollo's AI-driven personalised health programme. Additionally, the two companies agreed on a joint programme to deliver health services to rural communities in India.

100 项与 Swansea University 相关的药物交易

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100 项与 Swansea University 相关的转化医学

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