Delving into the Latest Updates on Mokpo National University with Synapse

概览

疾病领域	数量

感染	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

Akt-1 x Akt-2 x EGFR	1

关联

1

项与 Mokpo National University 相关的药物

Licochalcone C

靶点

Akt-1 x Akt-2 x EGFR

作用机制

AKT1基因抑制剂 [+2]

在研机构

Universidade Estadual Paulista Júlio De Mesquita Filho Unesp [+1]

原研机构-

在研适应症

幽门螺杆菌感染 [+2]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

2

项与 Mokpo National University 相关的临床试验

NCT01102023 / Completed临床3期IIT

Effect of Solar Salt Diet in Elderly Hypertensive Patients

High sodium intake causes hypertension. Various efforts for reducing salt consumption are proceeding all over the world. Solar salt contains reduced sodium and abundant mineral, such as calcium, potassium, and magnesium, comparing to ordinary salt. Use of solar salt, instead of ordinary salt, may have beneficial effects to blood pressure.
The investigators are going to conduct a preliminary study that can support antihypertensive effect of solar salt intake.

开始日期-

申办/合作机构

Chung-Ang University Hosptial

[+1]

KCT0009655 / CompletedN/AIIT

Effects of Virtual reality simulation prior to clinical placement as means to practice nursing diagnosis: multi-center RCT

开始日期2023-10-18

申办/合作机构

Mokpo National University

100 项与 Mokpo National University 相关的临床结果

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0 项与 Mokpo National University 相关的专利（医药）

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4,022

项与 Mokpo National University 相关的文献（医药）

2024-12-31·Animal Cells and Systems

MiR-29 and MiR-140 regulate TRAIL-induced drug tolerance in lung cancer

作者: Park, Sang Hee ; Yoo, Yongjin ; Illia, Shaginyan ; Kim, Yeonwoo ; Lee, Tae Jin ; Seo, Jimin ; Kim, Sung-Hak ; Lee, Ji Won ; Seo, Jong Bae ; Park, Hyun Woo ; Kim, Inki ; Chang, Min ; Lee, Ki Wook ; Jeon, Suhyun ; Lo, Han-En ; Suh, Sung-Suk ; Kim, Suyeon ; Joshi, Pooja ; Jeon, Young-Jun ; Croce, Carlo M.

2024-12-01·Environmental Pollution

Chronic UVB exposure induces hepatic injury in mice: Mechanistic insights from integrated multi-omics

Article

作者: Tong, Tao ; Huang, Kunlun ; Guo, Jingya ; Kang, Seong-Gook ; Lao, Yujie ; Geng, Ruixuan

Chronic UVB exposure poses a significant threat to both skin and visceral health. In recent years, the adverse role of chronic UVB exposure in liver health has been suggested but not fully elucidated. This study aims to comprehensively investigate the effects of chronic UVB exposure on liver health in male SKH-1 hairless mice and clarify potential mechanisms through multi-omics approaches. The findings suggested that 10-week chronic skin exposure to UVB not only triggers hepatic inflammation and oxidative stress but also, more importantly, results in lipid metabolism abnormalities in the liver. Hepatic transcriptomic analysis revealed significant alterations in various signaling pathways and physiological processes associated with inflammation, oxidative stress, and lipid metabolism. Further lipidomic analysis illustrated significant changes in the metabolism of glycerolipids, sphingolipids, and glycerophospholipids in the liver following chronic UVB exposure. The 16S rRNA sequencing analysis indicated that chronic UVB exposure disrupts the structure and function of the microbiota. In search of potential mechanisms used by the microbiome to regulate the hepatic disease morphology, we filtered mouse fecal supernatants and cultured the supernatants with HepG2 cells. Fecal supernatant from UVB-exposed mice induced increased secretion of the inflammatory cytokine IL-8, accumulation of MDA, reduced SOD activity, and decreased lipid content in normal hepatic cells. In summary, skin chronic exposure to UVB induces multiple liver injuries and gut microbiota dysbiosis in mice and gut microbiota metabolites may be one of the contributing factors to hepatic injury caused by chronic UVB exposure. These discoveries deepen the comprehension of the health risks associated with chronic UVB exposure.

2024-11-01·Aquaculture

Palliative effect of abalone insulin-related peptide 2 on emersion stress-induced hyperglycemia in the Pacific abalone (Haliotis discus hannai)

作者: Oh, Young Dae ; Chung, J. Sook ; Choi, Mi-Jin ; Lim, Han Kyu

The Pacific abalone (Haliotis discus hannai), an economically important marine mollusk in East Asia, is often exposed to extreme environments, such as high water temperatures during summer and air exposure during handling or transportation.These stressful conditions lead to hyperglycemia and the generation of reactive oxygen species (ROS), resulting in oxidative stress and subsequent cell damage in the organism.To understand the role of insulin-related peptides in the regulation of elevated hemolymph glucose, hyperglycemia was confirmed in abalone under high water temperature and air (emersion) exposure (p < 0.05).To prove the existence of a glucose regulatory system in abalone, changes in hemolymph glucose were measured after bovine insulin injection, and hemolymph glucose was lowered by bovine insulin injection in hyperglycemia caused by both stressors (p < 0.05), supporting the existence of a glucose regulatory system functionally similar to that of vertebrates.Among the three abalone insulin-related peptides (AIPs), which were previously reported to be upregulated along with hemolymph glucose levels upon feeding, the relative mRNA expression of AIP2 in the cerebral ganglion showed a close correlation with high water temperature and emersion stress, which peaked 12 h after treatment (p < 0.05).Based on these results, we focused on the function of AIP2 in glucose homeostasis and characterized the localization of AIP2 mRNA-expressing cells in the cerebral ganglion using in situ hybridization.Pos. signals from RNA probes were detected in neural cortex cells in the cerebral ganglion.Furthermore, suppressing AIP2 mRNA expression using RNA interference with double-stranded RNA (dsRNA) revealed that dsRNA-AIP2 injected abalone maintained high hemolymph glucose levels after 24 h of recovery following 1 h of emersion stress (p < 0.01).In contrast, abalones that received dsRNA-GFP and molluscan saline showed relatively rapid clearance of hemolymph glucose.This study demonstrates that AIP2 gene expression affects the recovery rate from emersion stress-induced hyperglycemia by regulating hemolymph glucose.

100 项与 Mokpo National University 相关的药物交易

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100 项与 Mokpo National University 相关的转化医学

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