排名前五的靶点	数量

HSP90(Heat shock 90kDa proteins)	2
DprE1(FAD依赖性十聚丙烯基磷酰基-β-D-呋喃核糖二氧化酶)	2
SHIP1(磷脂酰肌醇-3,4,5-三磷酸5-磷酸酶1)	1
TOP2B(DNA topoisomerase II beta)	1

关联

项与 University of Charles 相关的药物

AQX-C5

靶点

SHIP1

作用机制

SHIP1激活剂

在研机构

University of Charles [+1]

原研机构

Neoleukin Therapeutics, Inc.

在研适应症

慢性淋巴细胞白血病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

ICRF-193

靶点

TOP2B

作用机制

TOP2B抑制剂

在研机构

University of Charles

原研机构

Imperial Cancer Research Technology

在研适应症

心脏毒性

非在研适应症

肿瘤

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Reblastatin

靶点

HSP90

作用机制

HSP90 抑制剂

在研机构

University of Charles

原研机构

University of Charles

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

256

项与 University of Charles 相关的临床试验

NCT06543589 / Not yet recruitingN/AIIT

A Randomised Trial Comparing of High Flow Nasal Cannula Versus Cpap for Initial Respiratory Stabilisation of Very Premature Infants

Non-invasive continuous positive airway pressure (CPAP) stabilizes premature newborns, but its optimal pressure is unknown. High-flow nasal cannula (HFNC) is an alternative that minimizes trigeminal stimulation but lacks precise pressure control. Initial studies show HFNC's feasibility and effectiveness. This study hypothesizes that HFNC can deliver adequate pressure, reduce the need for positive pressure ventilation, and support safe stabilization of very premature infants. The trial compares the effectiveness and safety of HFNC versus CPAP in the delivery room and during transport to the neonatal intensive care unit in very premature infants. The primary objective is to compare HFNC and CPAP in reducing the need for positive pressure ventilation in very premature infants immediately after birth. The study includes very premature infants delivered between 28+0 and 31+6 weeks gestation in 10 tertiary referral centers (nine in the Czech Republic, one in Slovakia). Approximately 443 patients are required to detect a 15% relative decrease in the need for positive pressure ventilation between trial groups. Centers will be randomized to either CPAP or HFNC at each time period, with parental consent obtained before birth. The primary endpoint is the proportion of neonates requiring positive pressure ventilation within the first 10 minutes post-birth.

开始日期2024-12-01

申办/合作机构

University of Charles

NCT06521060 / Not yet recruitingN/AIIT

The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial Lesions

The Tru-cut biopsy (TCB) for targeting pelvic tumors is well established in gynecologic oncology. However, its reliability for differentiating of uterine sarcoma in "myoma-like" uterine lesions has been confirmed by only a few studies, which were either retrospective or provided only pilot result on the limited number of prospectively enrolled patients (N=34). Proving that preoperative TCB can provide accurate information about the histological nature of the tumor would have great impact for setting an adequate tailored oncologically safe approach, especially in patients with sonographically atypical lesions. Additionally, the biopsy should be safe, with transcervical, transuterine cavity ("in organ" biopsy) approaches preferred to avoid the risk of needle canal contamination if sarcoma is diagnosed. The purpose of this study is to evaluate the accuracy of the Tru-cut biopsy (TCB) of sonographically atypical myometrial lesions as a complementary diagnostic method in the preoperative management of patients scheduled for uterus preserving procedure or hysterectomy. Additionally, we aim to assess the impact of this procedure on patients´ quality of life and clinical management. MYSTR is a single arm, prospective, multicentric cohort study.

开始日期2024-10-01

申办/合作机构

University of Charles

NCT06478342 / Not yet recruitingN/AIIT

Left Atrial Function After Pulsed Field Ablation of Atrial Fibrillation

Introduction: Pulsed field ablation (PFA) has emerged in routine clinical practice as a new promising technology in catheter-based treatment of atrial fibrillation (AF). The ease of PFA technology enables more extensive ablation in shorter time. On one hand, extensive ablation is advocated to decrease the AF recurrence in persistent patients, on the other hand it is an important predictor of developing left atrial stiff syndrome with a reported incidence rate of 3.7 - 8.2 % in persistent patients during the era of radiofrequency ablation.
Goals of the study: The main hypothesis is that the LA function (strain) will tend to decline after extensive PFA. It will be assessed using transthoracic echocardiography (TTE) and magnetic resonance (MRI).
Secondary endpoint analysis will include the evaluation of the distribution of late gadolinium enhancement (LGE) after ablation compared to baseline scans, evaluation of heart failure biomarkers after ablation, and description of the rate of AF recurrence.
Methods: This project is a prospective, nonrandomised, two-centre (University Hospital Kralovske Vinohrady and University Hospital Motol) observational study including 50 non-paroxysmal AF patients with indication for catheter ablation. Before the ablation, all patients will undergo LGE MRI and TTE (after cardioversion if AF present). The ablation procedure will be performed using pulsed field technology and will include pulmonary vein isolation, posterior wall ablation and mitral isthmus ablation. Patients will be followed for 6 months. 3 months after the ablation, LGE MRI will be performed. TTE examinations will be carried out on the day after the ablation, at 3 and at 6 months. Heart failure biomarkers (N-terminal proatrial natriuretic peptide, fibroblast growth factor 23, and galectin 3) levels will be analysed at baseline, and 3 and 6 months after the procedure. ECG Holter monitoring will be performed at 3- and 6-months visits.

开始日期2024-10-01

申办/合作机构

University of Charles

100 项与 University of Charles 相关的临床结果

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0 项与 University of Charles 相关的专利（医药）

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53,211

项与 University of Charles 相关的文献（医药）

2024-12-31·The aging male : the official journal of the International Society for the Study of the Aging Male

Sexual function and pelvic floor function in men with systemic sclerosis compared to healthy controls: a cross-sectional study

Article

作者: Bečvář, Radim ; Štorkánová, Hana ; Šenolt, Ladislav ; Vencovský, Jiří ; Heřmánková, Barbora ; Komarc, Martin ; Špiritović, Maja ; Oreská, Sabína ; Pavelka, Karel ; Tomčík, Michal

OBJECTIVES:

This cross-sectional study aimed to compare the sexual function (SF) and pelvic floor function of men with systemic sclerosis (SSc) with age-matched healthy controls (HC) and to identify the implications of clinical features on SF.

MATERIAL AND METHOD:

Twenty SSc males and 20 HC aged 18-70 years completed eleven questionnaires assessing SF [International Index of Erectile Function (IIEF), Male Sexual Health Questionnaire (MSHQ)]; sexual quality of life: Sexual Quality of Life Questionnaire-Male (SQoL-M); pelvic floor function: Pelvic Floor Impact Questionnaire-Short Form 7 (PFIQ-7), fatigue, depression, physical fitness, functional disability, and quality of life. Clinical data were collected.

RESULTS:

Significantly worse SF was observed in patients (median IIEF erectile function 12 in SSc versus 29 in HC, p < 0.001), with 70% reporting erectile dysfunction (ED) compared to 15% in HC. However, no significant difference was observed regarding pelvic floor function (median PFIQ7 8.8 in SSc versus 7.0 in HC, p = 0.141). Impaired SF was associated with higher disease activity, increased systemic inflammation, more pronounced fatigue, reduced physical fitness, severe depression, impaired overall quality of life, dyspepsia, and arthralgias (p < 0.05 for all).

CONCLUSIONS:

Sexual dysfunction is highly prevalent in our SSc patients, whereas pelvic floor dysfunction is unlikely to be associated with these problems.

2024-12-31·RNA Biology

Truncating the spliceosomal ‘rope protein’ Prp45 results in Htz1 dependent phenotypes

Article

作者: Gahura, Ondřej ; Půta, František ; Valentová, Anna ; Převorovský, Martin ; Groušlová, Martina ; Folk, Petr ; Hao, Xinxin ; Liu, Beidong ; Sunnerhagen, Per ; Abrhámová, Kateřina

Spliceosome assembly contributes an important but incompletely understood aspect of splicing regulation. Prp45 is a yeast splicing factor which runs as an extended fold through the spliceosome, and which may be important for bringing its components together. We performed a whole genome analysis of the genetic interaction network of the truncated allele of PRP45 (prp45(1-169)) using synthetic genetic array technology and found chromatin remodellers and modifiers as an enriched category. In agreement with related studies, H2A.Z-encoding HTZ1, and the components of SWR1, INO80, and SAGA complexes represented prominent interactors, with htz1 conferring the strongest growth defect. Because the truncation of Prp45 disproportionately affected low copy number transcripts of intron-containing genes, we prepared strains carrying intronless versions of SRB2, VPS75, or HRB1, the most affected cases with transcription-related function. Intron removal from SRB2, but not from the other genes, partly repaired some but not all the growth phenotypes identified in the genetic screen. The interaction of prp45(1-169) and htz1Δ was detectable even in cells with SRB2 intron deleted (srb2Δi). The less truncated variant, prp45(1-330), had a synthetic growth defect with htz1Δ at 16°C, which also persisted in the srb2Δi background. Moreover, htz1Δ enhanced prp45(1-330) dependent pre-mRNA hyper-accumulation of both high and low efficiency splicers, genes ECM33 and COF1, respectively. We conclude that while the expression defects of low expression intron-containing genes contribute to the genetic interactome of prp45(1-169), the genetic interactions between prp45 and htz1 alleles demonstrate the sensitivity of spliceosome assembly, delayed in prp45(1-169), to the chromatin environment.

2024-12-31·RNA biology

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

Article

作者: Hrdlicka, Jaroslav ; Olsen, Mark ; Hlavackova, Marketa ; Kolar, Frantisek ; Karelson, Mati ; Holzerova, Kristyna ; Benak, Daniel

Cardiac tolerance to ischaemia can be increased by dietary interventions such as fasting, which is associated with significant changes in myocardial gene expression. Among the possible mechanisms of how gene expression may be altered are epigenetic modifications of RNA - epitranscriptomics. N⁶-methyladenosine (m⁶A) and N⁶,2'-O-dimethyladenosine (m⁶Am) are two of the most prevalent modifications in mRNA. These methylations are reversible and regulated by proteins called writers, erasers, readers, and m⁶A-repelled proteins. We analysed 33 of these epitranscriptomic regulators in rat hearts after cardioprotective 3-day fasting using RT-qPCR, Western blot, and targeted proteomic analysis. We found that the most of these regulators were changed on mRNA or protein levels in fasting hearts, including up-regulation of both demethylases - FTO and ALKBH5. In accordance, decreased methylation (m⁶A+m⁶Am) levels were detected in cardiac total RNA after fasting. We also identified altered methylation levels in Nox4 and Hdac1 transcripts, both of which play a role in the cytoprotective action of ketone bodies produced during fasting. Furthermore, we investigated the impact of inhibiting demethylases ALKBH5 and FTO in adult rat primary cardiomyocytes (AVCMs). Our findings indicate that inhibiting these demethylases reduced the hypoxic tolerance of AVCMs isolated from fasting rats. This study showed that the complex epitranscriptomic machinery around m⁶A and m⁶Am modifications is regulated in the fasting hearts and might play an important role in cardiac adaptation to fasting, a well-known cardioprotective intervention.

项与 University of Charles 相关的新闻（医药）

2024-10-17

·PRNewswire

Nikon Small World Competition Celebrates 50 Years with Groundbreaking Image of Brain Tumor Cells

Celebrating its golden anniversary, Nikon Small World honors a stunning photo of brain tumor cell structures, advancing our understanding of neurodegenerative diseases. MELVILLE, N.Y., Oct. 17, 2024 /PRNewswire/ -- Nikon Instruments Inc. today announced the winners of the 50th annual Nikon Small World Photomicrography Competition, celebrating five decades of excellence in microscopy and digital imaging. This year's first place prize was awarded to Dr. Bruno Cisterna, with assistance from Dr. Eric Vitriol of Augusta University, for his groundbreaking image of differentiated mouse brain tumor cells, highlighting the actin cytoskeleton, microtubules, and nuclei. This image reveals how disruptions in the cell's cytoskeleton – the structural framework and "highways" known as microtubules – can lead to diseases like Alzheimer's and ALS. Continue Reading Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Dr. Cisterna's research revealed that profilin 1 (PFN1), a protein crucial for building the cell's structure, plays a key role in maintaining the microtubule highways essential for cellular transport. When PFN1 or related processes are disrupted, these highways can malfunction, leading to cellular damage similar to what is observed in neurodegenerative diseases. "One of the main problems with neurodegenerative diseases is that we don't fully understand what causes them," said Dr. Cisterna. "To develop effective treatments, we need to figure out the basics first. Our research is crucial for uncovering this knowledge and ultimately finding a cure. Differentiated cells could be used to study how mutations or toxic proteins that cause Alzheimer's or ALS alter neuronal morphology, as well as to screen potential drugs or gene therapies aimed at protecting neurons or restoring their function." His patience and determination were crucial in capturing his image. "I spent about three months perfecting the staining process to ensure clear visibility of the cells. After allowing five days for the cells to differentiate, I had to find the right field of view where the differentiated and non-differentiated cells interacted. This took about three hours of precise observation under the microscope to capture the right moment, involving many attempts and countless hours of work to get it just right." The hard work behind this discovery underscores its significance, bringing researchers closer to answers that could potentially transform millions of lives. "After three years of research, we finally published our findings four months ago in the Journal of Cell Biology, and there's still more work to be done," said Dr. Cisterna. "I'm deeply passionate about scientific imaging; I've been following the Nikon Small World contest for about 15 years. It's an incredible contest that highlights the beauty of photomicrography but also inspires continued exploration and innovation in the field." Eric Flem, Senior Manager, CRM and Communications at Nikon Instruments, shares a similar perspective on the competition. "At 50 years, Nikon Small World is more than just an imaging competition – it's become a gallery that pays tribute to the extraordinary individuals who make it possible. They are the driving force behind this event, masterfully blending science and art to reveal the wonders of the microscopic world and what we can learn from it to the public." He went on to add, "Sometimes, we overlook the tiny details of the world around us. Nikon Small World serves as a reminder to pause, appreciate the power and beauty of the little things, and to cultivate a deeper curiosity to explore and question." Second place was awarded to Dr. Marcel Clemens for his image of an electrical arc between a pin and a wire, produced by applying a potential difference of 10,000 volts. Third place was awarded to Chris Romaine for his image of a cannabis plant leaf. The bulbous structures are trichomes, or hair-like plant appendages, and the bubbles inside are cannabinoid vesicles, fluid-filled, blister-like structures. In total, Nikon Small World recognized 87 photos out of thousands of entries from scientists and artists across the globe. The 2024 judging panel included: Adrian Coakley, Director of Photography at National Geographic Books Michelle S. Itano, Ph.D., Assistant Professor of Cell Biology and Physiology and Director of the Neuroscience Microscopy Core at the University of North Carolina at Chapel Hill Emily Petersen, Photography Managing Editor at Science Magazine Clare Waterman, Ph.D., Cell Biologist and Member of the National Academy of Sciences Jennifer C. Waters, Ph.D., Director of the Core for Imaging Technology & Education at Harvard Medical School Samantha Yammine, Ph.D., Neuroscientist and Science Communicator For additional information, please visit , or follow the conversation on Facebook, Twitter @NikonSmallWorld and Instagram @NikonInstruments. NIKON SMALL WORLD WINNERS 1st Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Super-Resolution 100X (Objective Lens Magnification) 2nd Place Dr. Marcel Clemens Verona, Veneto, Italy Electrical arc between a pin and a wire Image stacking for the pin and wire combined with long exposure for the electrical arcs 10X (Objective Lens Magnification) 3rd Place Chris Romaine Kandid Kush Port Townsend, Washington, USA Leaf of a cannabis plant. The bulbous glands are trichomes. The bubbles inside are cannabinoid vesicles. Image Stacking 20X (Objective Lens Magnification) 4th Place Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Section of a small intestine of a mouse Fluorescence 10X (Objective Lens Magnification) 5th Place Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Cluster of octopus (Octopus hummelincki) eggs Darkfield, Stereomicroscopy, Focus Stacking 3X (Objective Lens Magnification) 6th Place Henri Koskinen Helsinki University Helsinki, Uudenmaan lääni, Finland Slime mold (Cribraria cancellata) Image Stacking, Polarized Light, Reflected Light 10X (Objective Lens Magnification) 7th Place Gerhard Vlcek Maria Enzersdorf, Austria Cross section of European beach grass (Ammophila arenaria) leaf Brightfield, Image Stacking 10X (Objective Lens Magnification) 8th Place Stephanie Huang Victoria University of Wellington School of Biological Sciences; School of Psychology Wellington, New Zealand A neuron densely covered in dendritic spines from the striatum of an adult rat brain Confocal, Deconvolution, Image Stacking 60X (Objective Lens Magnification) 9th Place John-Oliver Dum Medienbunker Produktion Bendorf, Rheinland Pfalz, Germany Pollen in a garden spider (Araneus) web Image Stacking 20X (Objective Lens Magnification) 10th Place Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of black truffle (Tuber melanosporum) Confocal 63X (Objective Lens Magnification) 11th Place Dr. Ferenc Halmos Bánd, Veszprém, Hungary Slime mold on a rotten twig with water droplets Image Stacking 0.7X - 4.5X (Objective Lens Magnification) 12th Place Daniel Knop Oberzent-Airlenbach, Hessen, Germany Wing scales of a butterfly (Papilio ulysses) on a medical syringe needle Image Stacking 20X (Objective Lens Magnification) 13th Place Paweł Błachowicz Bedlno, Świętokrzyskie, Poland Eyes of green crab spider (Diaea dorsata) Image Stacking, Reflected Light 20X (Objective Lens Magnification) 14th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Recrystallized mixture of hydroquinone and myoinositol Polarized Light 10X (Objective Lens Magnification) 15th Place Sébastien Malo Saint Lys, Haute-Garonne, France Isolated scales on Madagascan sunset moth wing (Chrysiridia ripheus) Darkfield, Image Stacking, Reflected Light 40X (Objective Lens Magnification) 16th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Two water fleas (Daphnia sp.) with embryos (left) and eggs (right) Darkfield, Polarized Light 10X (Objective Lens Magnification) 17th Place Dr. Frantisek Bednar Svosov, Zilinsky, Slovak Republic Stonewort algae (Chara virgata) reproductive organs - oogonia (female organs) and antheridia (male organs) Darkfield 4X (Objective Lens Magnification) 18th Place Alison Pollack San Anselmo, California, USA An insect egg parasitized by a wasp Image Stacking, Reflected Light 10X (Objective Lens Magnification) 19th Place Alison Pollack San Anselmo, California, USA Seed of a Silene plant Image Stacking, Reflected Light 10X (Objective Lens Magnification) 20th Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Early stage of mouse neuroblastoma cell differentiation (actin, microtubules, and mitochondria) Super-Resolution 100X (Objective Lens Magnification) HM Christopher Algar Hounslow, Middlesex, United Kingdom Brine shrimp Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) HM Dr. Kseniia Bondarenko University of Edinburgh Institute for Immunology and Infection Research Edinburgh, MidLothian, United Kingdom Acute-stage parasites of Toxoplasma gondii in a human skin cell Expansion Microscopy, Confocal, Deconvolution 100X (Objective Lens Magnification) HM Dr. Anja de Lange University of Cape Town Neuroscience Institute & Department of Human Biology Cape Town, Western Cape, South Africa Astrocytes surrounding a blood vessel in a thin slice of human brain Confocal 40X (Objective Lens Magnification) HM Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Intestinal villi Fluorescence 20X (Objective Lens Magnification) HM Daniel Evrard Aywaille, Liege, Belgium Vinyl player needle on scratched vinyl disk Image Stacking, Polarized Light 20X (Objective Lens Magnification) HM Randy Fullbright Fullbright Studio Vernal, Utah, USA Agatized dinosaur bone Image Stacking 10X (Objective Lens Magnification) HM Dr. David Maitland St. Andrews, Fife, United Kingdom Transverse section of rachis (stem) of bracken fern (Pteridium aquilinum) Differential Interference Contrast (DIC) 5X (Objective Lens Magnification) HM Angus Rae Australian National University Centre for Advanced Microscopy MacGregor, Australian Capital Territory, Australia Autofluorescence in the face of a little two-spotted ladybird (Diomus notescens) Fluorescence lifetime imaging microscopy (FLIM) 20X (Objective Lens Magnification) HM Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Antenna of a mole crab Confocal 10X (Objective Lens Magnification) HM Jochen Stern Mannheim, Baden-Wuerttemberg, Germany Golden bug eggs on a sage leaf Image Stacking 20X (Objective Lens Magnification) HM Dr. Bruce Douglas Taubert Glendale, Arizona, USA Ocelli between the compound eyes of a yellow jacket Reflected Light 10X (Objective Lens Magnification) HM Kevin Terretaz CRBM-CNRS Montpellier, Hérault, France Mosquito cells in culture with fluorescent markers for DNA and microtubules Confocal 63X (Objective Lens Magnification) IoD Dr. Sherif Abdallah Ahmed Tanta University, Faculty of Science Department of Zoology Tanta, Egypt, Arab Republic Anterior section of palm weevil Image Stacking 4X (Objective Lens Magnification) IoD Anne Patricia Algar Hounslow, Middlesex, United Kingdom Mosquito larva Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) IoD Dr. Florian Alonso University of Bordeaux BioTis-INSERM U1026 Pessac, Gironde, France Mouse aortic endothelium stained for beta-catenin (green), laminin (purple), smooth muscle actin (red), and Hoechst (cyan) Confocal 63X (Objective Lens Magnification) IoD Didier Barbet Club Français de Microscopie Bailly, France Fracture surface of mica (mineral) Differential Interference Contrast (DIC) 10X (Objective Lens Magnification) IoD Timothy Boomer WildMacro.com Vacaville, California, USA Slime mold (Prototrichia metallica) Image Stacking 10X (Objective Lens Magnification) IoD Zhang Chao National Astronomical Observatories, Chinese Academy of Sciences Beijing, China Beach sand Reflected Light 10X (Objective Lens Magnification) IoD Joshua Coogler Dallas, North Carolina, USA Moss sporophyte with spores (green) Image Stacking 10X (Objective Lens Magnification) IoD Nikky Corthout & Miranda Dyson VIB (Flanders Institute of Biotechnology) Center for Brain and Disease Research Leuven, Vlaams-Brabant, Belgium Fruit fly (Drosophila) brain vasculature Confocal, Fluorescence, Image Stacking, Super-Resolution 25X (Objective Lens Magnification) IoD Nadia Efimova Amicus Therapeutics Philadelphia, Pennsylvania, USA Dandelion pappus Confocal, Fluorescence 20X (Objective Lens Magnification) IoD Dr. Laurent Formery & Dr. Nathaniel Clarke Stanford University Department of Molecular and Cell Biology Pacific Grove, California, USA Nervous system of a young sea star Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Karl Gaff Dublin, Ireland Larva of a midge fly (Chironomidae) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Dr. Nick Gatford University of Oxford Nuffield Department of Clinical Neurosciences (NDCN) Oxford, Oxfordshire, United Kingdom A network of dopaminergic neurons generated from human stem cells Super-Resolution 63X (Objective Lens Magnification) IoD Dr. Saikat Ghosh National Institutes of Health NICHD Bethesda, Maryland, USA Human neurons Confocal 40X (Objective Lens Magnification) IoD Gerd A. Günther Düsseldorf, Germany Cross section of a beach grass (Ammophila arenaria) leaf Fluorescence 20X (Objective Lens Magnification) IoD Anna-Mari Elisabeth Haapanen-Saaristo University of Turku Turku Bioscience Centre / Cell Imaging & Cytometry Core and Zebrafish Core RAISIO, Varsinais-Suomi, Finland Nutrient storage cells in a tardigrade Confocal 25X (Objective Lens Magnification) IoD Dr. Martin Hein Lions Eye Institute Physiology and Pharmacology laboratory Nedlands, Western Australia, Australia Abnormal blood vessel formation in a human retina with severe diabetic retinopathy Confocal 20X (Objective Lens Magnification) IoD Wen Jie Ji Yin Works The Bureau of Microworld Exploration Beijing, China Integrated circuit chip Reflected Light 10X (Objective Lens Magnification) IoD Ted Kinsman Rochester Institute of Technology Photosciences Department Rochester, New York, USA A common house cat claw Polarized Light 10X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Opening of a hibiscus flower (Hibiscus moscheutos) exposing the pollen in four stages, each ten minutes apart Image Stacking 20X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Dorsal part of cuckoo wasp (Hedychrum gerstaeckeri) abdomen Image Stacking 20X (Objective Lens Magnification) IoD Dr. Håkan Kvarnström Bromma, Sweden Peacock plume feather Epi-Illumination, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Ewa Langner Washington University in St Louis Department of Medicine - Renal Division, Mahjoub Lab St Louis, Missouri, USA Mouse embryonic kidney showing interstitial fibroblasts (yellow), tubular epithelium (cyan), and nuclei (magenta) Confocal, Fluorescence, Image Stacking 40X (Objective Lens Magnification) IoD Dr. Amir Maqbool Lovely Professional University Department of Zoology Srinagar, Jammu and Kashmir, India Small fly killed by "zombie fly" fungus (Entomophthora muscae) Image Stacking 2X (Objective Lens Magnification) IoD Dr. Robert Markus University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Dandelion (Traxacum officinale) cross section showing curved stigma with pollen Confocal 10X (Objective Lens Magnification) IoD Dr. Robert Markus, Dr. Zeeshan Mohammad, Dr. Sarah Pashley & Dr. Rita Tewari University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Malaria parasites and mouse blood cells - tubulin (green), all proteins (purple), DNA (red) Confocal 63X (Objective Lens Magnification) IoD Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of a black Bagnoli truffle (Tuber mesentericum) Confocal 63X (Objective Lens Magnification) IoD Dr. Guillermo Moya Johns Hopkins University Department of Biology Baltimore, Maryland, USA Neuronal axons connecting to the muscles of the iris and the cornea Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Jacek Myslowski Wloclawek, Kujawko-Pomorskie, Poland Water mite (Arrenurus) Fluorescence, Image Stacking 6.3X (Objective Lens Magnification) IoD Aryah Nagarajan Falmouth University Institute of Photography Penryn, Cornwall, United Kingdom Spores releasing from the sori of a Polypody fern (Polypodium vulgare) Reflected Light, Transmitted Light, Focus Stacking 10X (Objective Lens Magnification) IoD Thomas Neumann Tübingen, Baden-Württemberg, Germany Ink dot on Japanese washi paper Brightfield, Image Stacking 20X (Objective Lens Magnification) IoD Satu Paavonsalo & Dr. Sinem Karaman University of Helsinki Individualized Drug Therapy Research Program, Faculty of Medicine, Helsinki, Finland Helsinki, Finland Blood vessels (color gradient) and endothelial cell nuclei (white) in the intestinal villi of a mouse Confocal 10X (Objective Lens Magnification) IoD Uwe Lange Hannover, Niedersachsen, Germany Pollen on the compound eyes of a fly Image Stacking 60X (Objective Lens Magnification) IoD Dr. Marko Pende MDI Biological Laboratory Murawala Lab Bar Harbor, Maine, USA Ladybug (Coccinellidae) on a clover (Trifolium repens) Confocal, Fluorescence, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Felice Placenti FP Nature and Landscape Photography Siracusa, Sicilia, Italy Potato tuber sprout Image Stacking, Reflected Light 1X (Objective Lens Magnification) IoD Alison Pollack San Anselmo, California, USA Slime mold (Lamproderma arcyrioides) Image Stacking, Reflected Light 10X (Objective Lens Magnification) IoD Dr. Gonzalo Quiroga Artigas CRBM-CNRS Montpellier, Herault, France Tardigrade (Hypsibius exemplaris) Confocal 40X (Objective Lens Magnification) IoD Chris Romaine Kandid Kush Port Townsend, Washington, USA Bract (part of the plants reproductive structures) of a cannabis plant. The bulbous glands are trichomes. Image Stacking 20X (Objective Lens Magnification) IoD Dr. Adolfo Ruiz De Segovia PARTICULAR Madrid, Spain Plant root Fiber Optic 2X (Objective Lens Magnification) IoD Yurim Seo, Dr. Mark Looney & Dr. Simon Cleary University of California, San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine San Francisco, California, USA Lymphatic vasculature (cyan) and vessels (red) of a mouse lung Confocal 4X (Objective Lens Magnification) IoD Dr. Leo Serra University of Cambridge Sainsbury Laboratory Cambridge, Cambridgeshire, United Kingdom Leaves arising from thale cress (Arabidopsis thaliana) meristem Confocal 20X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Aster anther cross section with pollen grains (green) Confocal 40X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Floret of a common chicory with pollen grains (spiky balls) Confocal 40x (Objective Lens Magnification) IoD Luna Šošo Zdravković, Michael Surala & Christian Madry Charité Universitätsmedizin Berlin Institute of Neurophysiology Berlin, Germany Pyramidal neuron in mouse hippocampus Confocal, Fluorescence, Image Stacking 30X (Objective Lens Magnification) IoD Dr. Bruce Douglas Taubert Glendale, Arizona, USA Mid-tibial tuft on a male orchid bee, used to attract mates Reflected Light 10X (Objective Lens Magnification) IoD Maxime Teixeira Laval University Department of Molecular Medicine Québec, Canada Cultured monkey kidney cells labeled for tubulin (blue) and actin (orange) showing pathological accumulation of alpha-syn aggregates (red) Confocal, Deconvolution, Image Stacking, Super-Resolution 100X (Objective Lens Magnification) IoD Dr. Theo Theune Oost-Souburg, Zeeland, Netherlands Abdominal skin of a tick that engorged with blood Image Stacking 50X (Objective Lens Magnification) IoD Dr. Grigorii Timin & Dr. Michel Milinkovitch University of Geneva Department of Genetics and Evolution Geneva, Switzerland Skin scales of a snake embryo stained with Fast Green dye Confocal 63X (Objective Lens Magnification) IoD Steven A. Valley Oregon Department of Agriculture (ODA) Entomology Lab Albany, Oregon, USA Immature male damselfly (Calopteryx aequabilis) Image Stacking, Reflected Light 5X (Objective Lens Magnification) IoD Dr. Bruno Vellutini Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Saxony, Germany Gene expression patterns in a drain fly embryo (Clogmia albipunctata) with an open eggshell Confocal 20X (Objective Lens Magnification) IoD Susannah Waxman & Dr. Ian Sigal University of Pittsburgh Department of Ophthalmology Pittsburgh, Pennsylvania, USA Optic nerve head collagen of a pig Image Stacking, Multiphoton 25X (Objective Lens Magnification) IoD Shao Yang Beijing Miteyide Culture Co., Ltd. Beijing, China Fiber of nylon stockings Polarized Light 5X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Graffiti from Berlin Wall stone section Image Stacking, Top Illumination 10X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Water mite (Hydrachna sp.) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Elkhan Yusifov & Dr. Martina Schaettin University of Zurich Department of Molecular Life Sciences Zurich, Switzerland Developing nervous system in the eye of a 7-day-old chick embryo Stereomicroscopy 10X (Objective Lens Magnification) IoD Ou Zhilei Guangdong Radio and Television Guangzhou, Guagndong, China Stamens of flowers (Anemone cathayensis Kitag. ex Ziman & Kadota) Image Stacking 10X (Objective Lens Magnification) About Nikon Small World Photomicrography Competition The Nikon Small World Competition is open to anyone with an interest in photography or video. Participants may upload digital images and videos directly at . For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or phone (631) 547-8569. Entry forms for Nikon's 2025 Small World and Small World in Motion Competitions are available at . About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacturing of optical, digital imaging technology and software for biomedical applications. For more information, please visit or contact us at 1-800-52-NIKON. SOURCE Nikon Instruments Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-09-03

·GlobeNewswire-Health Care

Amicus Therapeutics Announces Participation at the SSIEM 2024 Annual Symposium

PRINCETON, N.J., Sept. 03, 2024 (GLOBE NEWSWIRE) -- Amicus Therapeutics (Nasdaq: FOLD), today announced that five posters across its development programs will be included at the Society for the Study of Inborn Errors of Metabolism (SSIEM) 2024 Annual Symposium, being held September 3-6, 2024 in Porto, Portugal. Poster Sessions: Fabry Disease: Abstract Title: FollowME Fabry Pathfinders registry: patient-reported outcomes in a cohort of patients on migalastat treatment for at least two years (Poster #21180) Presenter: Aleš Linhart, D.Sc., Charles University and General University Hospital in Prague, Prague, Czech RepublicPoster Session: Wednesday, September 4, 6:15 – 8:15 p.m. WETLocation: Poster Room, Rosa Mota Pavilion Abstract Title: Quality of life of migalastat-treated adolescents with Fabry disease: results from the ASPIRE study and open-label extension (Poster #21202) Presenter: Amarilis Sanchez-Valle, MD, University of South Florida Health, Tampa, U.S.A.Poster Session: Wednesday, September 4, 6:15 – 8:15 p.m. WETLocation: Poster Room, Rosa Mota Pavilion Abstract Title: Exploring the journey of patients living with Fabry disease in Poland (Poster #20789) Presenter: Anna Moskal, The Association of Families with Fabry Disease, Wroclaw, PolandPoster Session: Wednesday, September 4, 6:15 – 8:15 p.m. WETLocation: Poster Room, Rosa Mota Pavilion Pompe Disease: Abstract Title: Post-baseline outcomes of the UK Early Access to Medicines Scheme registry for cipaglucosidase alfa plus miglustat in late-onset Pompe disease (Poster #20863) Presenter: Elaine Murphy, MD, University College London Hospitals, London, U.K.Poster Session: Wednesday, September 4, 6:15 – 8:15 p.m. WETGuided Poster Walk: Thursday, September 5, 12:10 – 1:40 p.m. WETLocation: Poster Room, Rosa Mota Pavilion Abstract Title: Miglustat: a first-in-class enzyme stabilizer for late-onset Pompe disease (Poster #20873) Presenter: Mark Roberts, MD, Salford Royal NHS Foundation Trust, Greater Manchester Neurosciences Centre, Manchester, U.K.Poster Session: Wednesday, September 4, 6:15 – 8:15 p.m. WETLocation: Poster Room, Rosa Mota Pavilion For more information on the SSIEM 2024 Annual Symposium, please visit ssiem2024.org. About Amicus Therapeutics Amicus Therapeutics (Nasdaq: FOLD) is a global, patient-dedicated biotechnology company focused on discovering, developing and delivering novel high-quality medicines for people living with rare diseases. With extraordinary patient focus, Amicus Therapeutics is committed to advancing and expanding a pipeline of cutting-edge, first- or best-in-class medicines for rare diseases. For more information please visit the company’s website at www.amicusrx.com, and follow on X and LinkedIn. CONTACTS: Investors: Amicus Therapeutics Andrew Faughnan Vice President, Investor Relations afaughnan@amicusrx.com(609) 662-3809 Media: Amicus Therapeutics Diana Moore Head of Global Corporate Communications dmoore@amicusrx.com(609) 662-5079 FOLD–G

2024-06-24

·药融圈

全球顶级CRO年收入突破40亿美金，预测下半年生物制药市场回暖

▲8月15-16日 NDC2024生物医药创新者峰会扫码立即报名注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需得到授权。药融圈此前发布【全球第7大CRO：查尔斯河业绩、利润攀升，护城河高建】一文中讲述了查尔斯河（Charles River Laboratories，CRL）如何从一只实验鼠发家，经历了几次业务结构变革，深耕、开拓，一步步成长为全球CRO巨头，以及在14年前“差点”收购了药明康德的故事。 2023年度，Charles River年收入首次超过40亿美元，全球员工达到了约21800名，生物制药客户超过4000家，包括100家大型制药公司。2023年，85%的FDA批准的药物和80%的罕见病和孤儿病药物都有Charles River参与的身影。作为全球知名的非临床CRO巨头，Charles River的研究模型、药物安全性评价和微生物解决方案处于市场领先地位。当前主要业务 Charles River的服务覆盖了药物研究与开发过程中除了人类临床试验以外的全部环节：基础研究、药物发现、临床前试验、临床开发、制造与商业化，主要业务包括三个方面：研究模型和服务（RMS）、药物发现和安全性评价（DSA），以及制造解决方案。研究模型和服务（RMS）：包括研究模型、研究模型服务和细胞解决方案（人体细胞制品）。研究模型包括小型研究模型的商业生产和销售，以及大型研究模型的供应。研究模型服务包括基因工程模型和服务（GEMS），执行合同育种和其他与基因工程模型相关的服务；研究动物诊断服务（RADS），提供与研究模型相关的健康监测和诊断服务；内包解决方案（IS），利用Charles River加速器和开发实验室（CRADL）选项，在客户的设施和Charles River的生态空间里，为客户的研究业务提供群体管理（包括招聘、培训、人员配备和管理服务）。（CRADL拥有约30个地点，提供全方位服务的交钥匙出租能力。）细胞解决方案提供来自正常的和经过动员的外周血和骨髓中，可控、一致、定制的原代细胞和血液成分。根据企业公开信息，RMS业务占公司总收入的19%，根据管理估计和公开市场信息，Charles River的RMS业务约占全球市场的40%，居于全球首位。RMS业务可提供约150种使用最为广泛的研究模型品系；在北美和欧洲销售的用于临床前研究的小型研究模型有大约二分之一来自于Charles River。药物发现和安全性评价（DSA）部门由两部分业务组成：药物发现服务和安全性评价，以支持潜在新药的研究、开发和法规要求的安全性检测，包括治疗性药物的发现和优化、体外和体内研究、实验室支持服务，以及战略性非临床咨询和项目管理，以支持产品开发。DSA业务占Charles River总收入的63%。 Charles River的药物发现服务覆盖大多数主要治疗领域，重点是肿瘤学和中枢神经系统领域，跨越了小分子和大分子、抗体和C>疗法，能够在客户的药物发现或早期开发项目的任何阶段与客户接触。自1999年以来，这部分业务为客户发现了超过100种临床前候选药物。Charles River是外包药物安全性评价服务的全球领导者，占全球市场的约30%，可提供一般和专业毒理学、生物分析、病理学、安全药理学、药物代谢和药代动力学（DMPK）服务，并在专业毒理学服务方面具有特长，覆盖了从吸入到输注到发育和生殖毒理学。2023年，Charles River推出了实时毒理学研究数据平台Apollo™。该公司认为，一个药物安全性评价项目的成本比一个晚期临床项目少5-10倍，在一定程度上激励了客户将研发支出集中于IND成就上，因此有望进一步推动外包的渗透。根据Charles River分析，药物发现和安全性评价（DSA）需求在2023全年趋于正常化，部分原因是biotech融资环境改善，另外，今年第一季度biotech融资规模创下了有记录以来第四高的单季度融资水平，后续将为这部分业务带来积极影响；同时，该公司认为biopharma客户的终端市场趋势将保持稳定，并将在2024年下半年开始改善。制造解决方案部门：包括微生物解决方案，该解决方案提供体外（非动物）批量释放测试产品、微生物检测产品和物种鉴定服务；生物制剂解决方案（生物制剂），执行生物制剂的专门测试（生物制剂测试解决方案），以及合同开发和制造产品和服务（CDMO）。2022年12月，Charles River出售了禽疫苗服务（禽）业务，该业务主要提供特定的无病原体的鸡蛋和鸡，此前归属于制造部门。制造业务占Charles River总收入的18%。根据企业官方信息，Charles River是全球领先的质量控制（QC）测试产品和服务提供商，可提供FDA授权的无菌生物制药产品的批量释放测试，拥有市场领先的平台，如Endosafe®内毒素检测、Accugenix®微生物鉴定和菌株分型、Celsis®快速微生物检测；在制造领域提供跨所有主要的C> CDMO平台的解决方案。Charles River约70%的微生物解决方案收入来自试剂/消耗品，创造了一个经常性收入。另外，该公司C> CDMO收入的65%来自基因修饰细胞治疗产品生产。该部分业务开展了1000项研究，支持了20项FDA批准的C>疗法。 2023年，Vertex Pharmaceuticals与CRISPR Therapeutics合作开发的全球首款CRISPR基因编辑疗法CASGEVY™（exagamglogene autotecmel[exa-cel]）成功获批，该疗法也是全球首款针对严重镰状细胞病（SCD）的基因编辑疗法。Charles River正是CASGEVY™的CDMO解决方案提供商，其孟菲斯CDMO工厂已获得美国/欧盟的批准，可用于生产CASGEVY™。该工厂也是北美第一家获得欧洲药品管理局批准的合同开发和生产组织（CDMO），可以商业化生产同种异体基因细胞治疗药物产品。截图自药融云数据库目前，Charles River的客户群体主要包括：生物制药公司、生物技术、农业和工业化学、生命科学、兽医学、医疗设备、诊断和消费品公司，以及合同研究和合同制造组织等其他商业实体，另外还包括领先的医院、学术机构和政府机构。Charles River与许多客户建立了稳定、长期的合作关系。在2023年，没有一个客户占该公司总收入的3.5%以上，也没有一个客户占三个业务部门收入的8%以上。该公司95%的客户来自北美和欧洲。未来，Charles River将继续追求扩大与大型生物制药客户以及许多大型中端市场客户的关系，并采取不同的形式，从首选的供应商安排到战略合作伙伴关系。这些关系的结构激励客户在Charles River的非临床投资组合中购买更多的产品和服务。由于这些关系的优势，Charles River对客户的规划过程将有更好的了解，进而获得更好的可预见性。动物实验替代方案&非人类灵长动物供应链在新药研究中，动物实验是非常重要的一环，但这一领域一直存在争议和伦理挑战，同时实验动物存在供需周期波动，价格不稳定，比如前两年出现的“天价猴”。在2022年的“柬埔寨长尾猕猴事件”之后，越来越多人关注到生物医学领域的动物实验问题，提出了对动物权益的担忧，并呼吁减少以动物为代价的实验。 Charles River以实验鼠起家，现在很大一部分收入也与实验动物息息相关。现在Charles River正在努力寻找动物实验替代方案，以减少对动物实验的依赖。 2024年4月16日，Charles River宣布将启动替代方法推进项目（Alternative Methods Advancement Project，AMAP）该计划致力于开发替代方案以减少动物试验。该计划囊括了公司在过去四年中最初的2亿美元投资以及额外投资3亿美元的五年目标，涉及一系列技术创新、合作伙伴关系和宣传工作，以减少动物试验的使用。一直以来，Charles River拥有自己的“人道关怀组织（HCI）”，确保对实验动物的人道关怀并实施3R原则（RepIacement替代、Reduction减少和Refinement改进）。在2023年，Charles River在长期实施的3R框架中增加了第四个“R”——Responsibility责任。AMAP项目致力于追求科技创新，并将公司的战略努力与推进动物替代品所需的重点相结合，从而兑现对4R的承诺。 2024年1月29日，Charles River宣布在其旗舰Endosafe®卡片技术的基础上，进一步推进创新，与重组级联试剂（rCR）相结合，推出了Endosafe Trillium™ rCR检测卡片。这是该公司首个不含动物源成分的快速细菌内毒素检测产品。从历史上看，内毒素检测依赖于大西洋鲎，其血液中含有鲎变形细胞溶解物（LAL），鲎试剂是植入式医疗器械和注射药品测试的关键组成部分，以确保不含可引起热原反应和感染性休克症状的内毒素。Trillium™ rCR配方通过三种重组蛋白（重组因子C、重组因子B和重组凝血酶）的优化配方和组成以及特定浓度的关键组分，模拟LAL酶级联反应，从而检测和定量天然环境内毒素。此外，该产品与现有的Endosafe®卡片仪器和软件套件完全对齐并集成，允许客户无缝过渡。 2024年6月4日，Charles River宣布与赛诺菲启动虚拟对照组（VCG）计划，该计划旨在通过使用回顾性数据集开发的选定匹配的虚拟对照动物，替代选定的对照组动物，从而减少动物的使用。VCG是一种数据驱动的数字创建，基于历史研究数据、参数和复杂的统计方法。VCG在一些临床试验中是一种既定的做法，但在临床前研究中的应用是新的尝试。Charles River正在与内部和外部利益相关者合作，包括生物制药行业的监管机构和领导者，以推进这项研究。Charles River和赛诺菲正在合作，在非临床毒理学项目中试点VCG，并探索其用途。 Charles River也曾因“柬埔寨长尾猕猴事件”受到过调查。在2024年JPM大会上，该公司提供了非人灵长类动物（NHP）供应计划的战略更新，致力于推进可持续和安全的NHP供应链实践和创新的临床前药物开发解决方案。加强对NHP供应链的保障措施：Charles River采用广泛、多层次的审计方法，包括更频繁的供应商审计/访问，在某些供应商进行基因检测以确认亲子关系，以及加强审计程序；增强数字记录保存；改进供应商的尽职调查和培训计划；与学术机构合作，开发了一个基因检测平台，确认NHP的目标繁殖状态，已在毛里求斯的NHP供应商进行验证和试点，计划在某些供应商实施基于风险的基因检测方法；与国家监管机构和政府当局密切合作，继续按照适用的法律和法规行事。 NHP供应链多样化：Charles River正维护和扩大跨多个国家的NHP供应来源，包括目前在毛里求斯和中国的供应商的所有权股份；该公司还承诺，当一个NHP来源国超过全球采购份额的30%时，将每年进行披露；2023年，Charles River Laboratories完成了对Noveprim Group额外41%股权的收购，从而获得90%的控股权。Noveprim Group是一家总部位于毛里求斯的非人灵长类动物（NHP）供应商，此次收购加强了DSA部门NHP供应链的多样性；扩大了北美NHP的检疫和持有能力，以增加安全库存。利用全球基础设施：建立灵活的运营基础设施，以适应当前监管环境下的全球客户需求，减轻NHP供应限制的总体影响。利用全球SA（药物安全性评价）基础设施，将更多的NHP研究转移到美国以外，以满足客户需求；继续支持恢复美国对柬埔寨NHP的进口，Charles River尚未恢复柬埔寨NHP进口到美国，但能够通过全球基础设施来满足客户的需求。创新为未来：坚持4R原则/减少NHP的使用，推动创新和替代方案的评估。评估临床前药物开发的替代技术（包括人工智能和生物模拟），以便在科学能力取得进步时继续保持在创新的前沿。增长策略：并购、战略合作和风险投资 Charles River将继续加强和扩展一系列产品和服务。该公司根据分子类型、研究阶段、治疗领域和所处行业提供解决方案，以确保公司的目标是广大客户需要解决的领域。通过强大的并购策略、对现有业务的有机投资以及战略合作模式，Charles River为未来的持续增长和发展做好了准备。 Charles River通过收购、技术合作伙伴关系和内部开发进行投资，以获得创新技术和专业知识。自2012年以来，该公司投资了超过45亿美元收购了超过25家公司。这些投资的重点是提高公司科学能力的广度，扩大全球规模，并保持在先进和新兴疗法方面的领导地位。目前，Charles River与超过20家企业或机构建立了积极的合作伙伴关系，在企业合作和许可方面投资超过1.35亿美元。最近的战略伙伴关系重点包括：Distributed Bio（收购）的抗体发现的能力；SAMDI Tech（收购）的无标签高通量筛选（HTS）；Deciphex的数字病理学；PathoQuest用于生物制剂QC检测的NGS（高通量测序）技术；Valo Health的人工智能驱动药物发现。 Charles River与生物技术公司Cypre的合作，在开发3D癌症模型方面开辟新的进展，该模型再现肿瘤内和周围的复杂组织，以确定新的治疗靶点，以供新一代癌症药物研究；与Valo Health的合作支持在药物开发早期对候选药物进行评估，使用计算模型预测化合物的有效性与毒性，以及代谢速度等。这两项合作均有利于减少对动物检测的依赖。Cypre和Valo Health都是AMAP替代项目中的例子。除了并购和战略合作，Charles River还通过风险投资（VC）支持成为新兴生物技术公司的首选合作伙伴，并扩大获得下一代科学和技术的机会。2023年，Charles River有大约10%的年收入来自于风投支持的企业。该公司通过风投关系（投资和收入）产生的平均年回报率为25%。 Charles River在中国 Charles River在2013年收购了维通利华（Vital River）75%的所有权，进入中国市场（此前的10余年，维通利华是Charles River在中国大陆地区唯一的授权生产商及动物模型分销商），随后在中国布局了越来越多的药物研究服务包括微生物检测、生物制品检测、Cradl新药加速实验室等。现如今，维通利华是Charles River在中国专注于动物模型的品牌，而查士利华则代表多类型研究服务的品牌（主要包括微生物解决方案和生物制品解决方案）。财务业绩 2023全年，Charles River总收入达41.3亿美元，同比增长3.9%；GAAP营业利润率为14.9%，2022年为16.4%；按照GAAP计算，2023年归属于普通股股东的净利润为4.746亿美元，同比减少2.4%；每股摊薄收益为9.22美元，同比下降2.7%。按照收入类型，Charles River全年服务类收入为34.4亿美元，同比增长6.9%，产品类收入为6.89亿美元，同比减少9.2%。按照部门类型，研究模型和服务（RMS）部门2023年收入7.923亿美元，同比增长7.2%，主要是由于更高的研究模型服务收入，特别是内包解决方案业务；药物发现和安全性评价（DSA）部门收入为26.2亿美元，同比增长7.9%，主要是由于药物安全性评价业务的需求增加；制造解决方案部门收入为7.214亿美元，同比减少8.6%，主要是因为禽类业务的剥离。 2024年第一季度，Charles River总收入为10.1亿美元，同比减少1.7%；GAAP营业利润率为12.5%，去年同期为16.3%；归属于普通股股东的净利润为6730万美元，同比下降34.7%；每股摊薄收益为1.30美元，同比减少35.3%。按照收入类型，Charles River今年第一季度服务类收入为8.169亿美元，同比减少4.7%，产品类收入为1.95亿美元，同比增长13.2%。按照部门类型，研究模型和服务（RMS）部门第一季度收入2.2亿美元，同比增长10.6%，主要是由于非人灵长类动物（NHP）业绩提高、由于价格的持续增长，小型研究模型业绩增长、研究模型服务业绩增长；药物发现和安全性评价（DSA）部门收入为6.05亿美元，同比减少8.6%，主要是由于销售下降，价格增长放缓，以及重组相关成本；制造解决方案部门收入为1.85亿美元，同比增长10.7%，主要是因为生物制剂检测服务收入、CDMO服务收入和微生物解决方案、内毒素产品收入的增加。根据Charles River最新业绩指引，公司2024全年总收入预计将增长1.0% - 4.0%，GAAP每股收益估计为7.60 - 8.10美元。此文仅用于向医疗卫生专业人士提供科学信息，不代表平台立场，不作任何用药推荐参考： NMPA/CDE；药融云数据www.pharnexcloud.com； FDA/EMA/PMDA；相关公司公开披露（正文图片均来自企业官方，除非另有说明）；全球第7大CRO：查尔斯河业绩、利润攀升，护城河高建； https://ir.criver.com/news-releases/news-release-details/charles-river-laboratories-launches-alternative-methods； https://ir.criver.com/news-releases/news-release-details/charles-river-introduces-first-rapid-animal-free-bacterial； https://ir.criver.com/news-releases/news-release-details/charles-river-laboratories-announces-development-nonclinical； https://www.criver-microbial.cn/news/company-news/2024/0228/34.html； https://ir.criver.com/news-releases/news-release-details/charles-river-laboratories-expand-research-models-business-china/；等等 8月峰会，扫码即可报名【关于药融圈】药融圈PRHub旨在帮助生物医药科技型企业进行品牌推广及商务拓展服务，针对客户的真实需求制定系统化解决方案，通过“翻译-降维-场景化”将客户的品牌信息以直白易懂的方式被公众知悉，同时在流量渠道覆盖100万+垂直用户基础上实现合作目的，帮助合作伙伴完成从品牌开始到商务为终的闭环营销服务。我们已经完成了数十场线下1000人规模的生物医药研发类会议，涵盖小分子新药，大分子新药，改良型新药，BD跨境交易等多个领域，服务了百余家上市/独角兽/生物技术/制药企业。

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