别名 BXR、NR1I2、Nuclear receptor subfamily 1 group I member 2 + [10] |
简介 Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
靶点 |
作用机制 PXR激动剂 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 PXR激动剂 [+1] |
在研机构- |
原研机构- |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2025-01-01 |
申办/合作机构 |
开始日期2024-12-01 |
开始日期2024-11-30 |
申办/合作机构 |