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7

项与九江学院附属医院相关的临床试验

ChiCTR2400087265 / Recruiting临床2期IIT

Clinical efficacy observation of using live Bacillus coagulans in patients with Parkinson's disease and constipation

开始日期2023-11-02

申办/合作机构

九江学院附属医院

NCT05965687 / Recruiting临床3期IIT

Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)

The purpose of this study is to determine the efficacy and safety of Normobaric Hyperoxia combined with intravenous thrombolysis for acute ischemic stroke.

开始日期2023-08-17

申办/合作机构

首都医科大学

[+15]

ChiCTR2200060569 / RecruitingIIT

Mechanism of NBO (normobaric hyperoxia) treatment on inflammatory injury after intracerebral hemorrhage - NMNBOICH

开始日期2022-05-22

申办/合作机构

九江学院附属医院

100 项与九江学院附属医院相关的临床结果

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0 项与九江学院附属医院相关的专利（医药）

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245

项与九江学院附属医院相关的文献（医药）

2025-02-01·Neural Regeneration Research

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Article

作者: Xiong, Yinyi ; Zhang, Xiaorong ; Zhu, Ling-Qiang ; Chen, Zhiying ; Liu, Dan ; Zhou, Qin

With an increase in global aging, the number of people affected by cerebrovascular diseases is also increasing, and the incidence of vascular dementia—closely related to cerebrovascular risk—is increasing at an epidemic rate. However, few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia patients. Similarly in Alzheimer’s disease and other neurological disorders, synaptic dysfunction is recognized as the main reason for cognitive decline. Nitric oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous system. Recently, nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular dementia. This review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction, neuroinflammation, oxidative stress, and blood–brain barrier dysfunction that underlie the progress of vascular dementia. Additionally, we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

2024-12-01·IBRO Neuroscience Reports

Chemokines play a role in nerve damage and neuroprotection in vascular dementia

Review

作者: Chen, Zhiying ; Ma, Jinming ; Yin, Xiaoping ; Zhang, Manqing ; Fu, Peijie

Various Chemotactic Factors (FCs) play different roles in neuronal injury in vascular dementia. CXCL5 and CCL11 exacerbate neurological injury by promoting inflammatory responses. CXCL12/SDF-1 and CX3CL1 play neuroprotective roles.CXCL13, XCL-1 and CCL2/ MCP-1 exacerbate neurological injury in the early stage, while exerting neuronal regeneration and neuroprotective effects in the chronic progressive phase. Chemokines often play an important role in the course of vascular dementia by regulating inflammatory responses, oxidative stress, and autophagy. Activation of microglia plays an important role in the regression of vascular dementia. Activated microglia M1 causes neuronal damage through the release of chemokines. And microglia M2 has anti-inflammatory effects and is involved in the repair of brain damage. Therefore, dynamic monitoring of various related FCs and understanding the relationship between FCs and microglia can help to understand and regulate the disease course progression of vascular dementia.At present, many scholars have confirmed in basic research that different subgroups of chemokines are closely related to vascular dementia. In clinical research, new immunotherapy methods that upregulate XCL-1 and drugs that regulate the activity of CCL2/CCR2 signaling pathways are being studied and promoted.

2024-09-16·Asian journal of surgery

Exploring the causal associations between immunoglobulin G N-glycosylation and chronic spinal pain: A Mendelian Randomization study.

Letter

作者: Liu, Zhengqiang ; Chen, Yuquan ; Chen, Yiwei ; Li, Jun

100 项与九江学院附属医院相关的药物交易

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100 项与九江学院附属医院相关的转化医学

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