Delving into the Latest Updates on Faculdade de Medicina de São José do Rio Preto with Synapse

概览

疾病领域	数量

免疫系统疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

TGF-β(转化生长因子β)	1

关联

1

项与 Faculdade de Medicina de São José do Rio Preto 相关的药物

Tranilast

曲尼司特

靶点

TGF-β

作用机制

TGF-β抑制剂

在研机构

St. Michael's Hospital [+7]

原研机构

Kissei Pharmaceutical Co., Ltd.

在研适应症

变应性结膜炎 [+6]

非在研适应症

哮喘 [+6]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1982-06-15

100 项与 Faculdade de Medicina de São José do Rio Preto 相关的临床结果

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0 项与 Faculdade de Medicina de São José do Rio Preto 相关的专利（医药）

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2,379

项与 Faculdade de Medicina de São José do Rio Preto 相关的文献（医药）

2024-11-01·Journal of Affective Disorders

Associations between a Brazilian suicide awareness campaign and suicide trends from 2000 to 2019: Joinpoint and regression discontinuity analysis

Article

作者: Damiano, Bianca Besteti Fernandes ; Beiram, Loren ; Moreira-Almeida, Alexander ; Miguel, Euripedes Constantino ; Salum, Giovanni Abrahão ; Hoffmann, Maurício Scopel ; Brunoni, André R ; Damiano, Rodolfo Furlan ; Rück, Christian ; Menezes, Paulo Rossi ; Tavares, Hermano

BACKGROUNDSuicide is a global health concern whose rates are soaring in many low-and-middle-income countries. Public awareness campaigns have been implemented in Brazil; however, their impact is uncertain.METHODSThis was an ecological study using population data from DATA-SUS, a Brazilian official notification system, selecting only deaths that were voluntarily self-inflicted (CID-10 × 60-X84). We analyzed all available data from 2000 to 2019 to assess trends before and after the national Yellow September (YS) campaign started in 2015. Differences in trends were assessed by Joinpoint Analysis (JA) and Regression Discontinuity Analysis (RDD), unadjusted and adjusted for economic factors.RESULTSOverall, there was a progressive increase in the rate of relative (per 100,000 inhabitants) number of suicides over time between 2000 and 2019 (57 % increase). The JA detected a change in the slope of the curve representing an acceleration in suicides starting in the year 2015. Adjusted RDD revealed the year that Yellow September started significantly change the slope of the association between time and rates of suicide (p_interaction < 0.01), and marginal analysis detected the coefficient increased from 0.07 (95%CI 0.04-0.10) to 0.27 (95%CI -0.07-0.60) suicides/year per 100,000 inhabitants.LIMITATIONSThe ecological nature of the manuscript compromises causational implications.CONCLUSIONSWe found an increase in suicidal trends in Brazil, against the global trend that coincides with the beginning of a large national awareness campaign. Although we cannot attribute causality, our results reinforce the need of further studies to better understand the role of awareness campaigns in suicide reduction interventions, including potential unintended effects.

2024-11-01·Public Health

Increase in suicide rates in the elderly population of the state of São Paulo, Brazil: Could Alzheimer's disease be a risk factor?

Article

作者: Rubatino Rodrigues, Juliano Flávio ; de Araújo Filho, Gerardo Maria ; Rodrigues, Lívia Peregrino

OBJECTIVESIn recent years, there has been an increase in suicide rates in Brazil. From 2015 to 2019, a 34% increase in self-inflicted deaths was observed. The aim of this study was to analyse population data to determine whether some subgroups of the population, specifically the elderly population with Alzheimer's disease, are at a greater risk of suicide.STUDY DESIGNAn analysis of population data was carried out.METHODSPopulation data from the state of São Paulo, Brazil, were obtained from two platforms: the Brazilian Institute of Geography and Statistics (IBGE); and the Brazilian Ministry of Health (DataSUS). Data were measured and compared in 2010 and 2022 using the two most recent censuses.RESULTSBetween 2010 and 2022, the number of registered deaths of patients with Alzheimer's increased by 21.93%. In addition, there was a 100.37% increase in suicides among the elderly population compared to a 37.78% increase in the general population.CONCLUSIONSIn recent years, there has been a notable increase in both suicides among the elderly and mortality rates attributed to Alzheimer's disease within São Paulo state, Brazil. However, it is not possible to conclude that the increase in suicide among the elderly is directly linked to Alzheimer's disease. To determine a correlation between suicide and Alzheimer's disease, further studies are required.

2024-10-01·Molecular and Cellular Endocrinology

Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells

Article

作者: Cucielo, Maira Smaniotto ; Cesário, Roberta Carvalho ; Seiva, Fábio Rodrigues Ferreira ; Guimarães, Fernando ; Gaiotte, Leticia Barbosa ; Reiter, Russel J ; Zuccari, Debora Aparecida P C ; Chuffa, Luiz Gustavo de Almeida ; Silveira, Henrique Spaulonci ; Vígaro, Renan Aparecido

Ovarian cancer (OC) adjusts energy metabolism in favor of its progression and dissemination. Because melatonin (Mel) has antitumor actions, we investigated its impact on energy metabolism and kinase signaling in OC cells (SKOV-3 and CAISMOV-24). Cells were divided into control and Mel-treated groups, in the presence or absence of the antagonist luzindole. There was a decrease in the levels of HIF-1α, G6PDH, GAPDH, PDH, and CS after Mel treatment even in the presence of luzindole in both OC cells. Mel treatment also reduced the activity of OC-related enzymes including PFK-1, G6PDH, LDH, CS, and GS whereas PDH activity was increased. Lactate and glutamine levels dropped after Mel treatment. Mel further promoted a reduction in the concentrations of CREB, JNK, NF-kB, p-38, ERK1/2, AKT, P70S6K, and STAT in both cell lines. Mel reverses Warburg-type metabolism and possibly reduces glutaminolysis, thereby attenuating various oncogenic molecules associated with OC progression and invasion.

100 项与 Faculdade de Medicina de São José do Rio Preto 相关的药物交易

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100 项与 Faculdade de Medicina de São José do Rio Preto 相关的转化医学

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