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最高研发阶段临床1期 |
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A First-in-human, Phase I, Multi-center, Open-label, Dose-escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Evidence of Antitumor Activity of IDOV-Immune in Adult Participants With Advanced Solid Tumors
This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cells and have the potential to stimulate the immune system to fight the tumor.
The purpose of this study is to determine the safety of IDOV-Immune, how well it is tolerated, and to identify the highest dose that can be safely given. Researchers will also study how the drug behaves in the body, how the immune system responds to it, and whether it shows any signs of shrinking tumors.
Participants will receive a single intravenous (IV) infusion of IDOV-Immune and will be closely monitored for side effects and any changes in their cancer.
This study is being conducted at multiple sites in the United States and Australia.
100 项与 ViroMissile, Inc. 相关的临床结果
0 项与 ViroMissile, Inc. 相关的专利(医药)
2023-12-01·Molecular Therapy - Oncolytics
miR-146a: Overcoming coldness in ovarian cancer
作者: Ye, Yanqi ; Chen, Nanhai G
Molecular Therapy--Oncolytics
miR-146a: Overcoming coldness in ovarian cancer
作者: Chen, Nanhai G. ; Ye, Yanqi
The researchers discovered the role of miR-146a by sampling tumors collected from patients diagnosed with HGSC to assess a panel of 54 tumoral microRNA (miRNA) expression levels.Extensive anal. revealed a pos. correlation between miR-146a expression and the expression level of CD8 mRNA, suggesting a potential role of miR-146a in promoting anti-tumor immune responses.These findings serve as a foundation for exploring the therapeutic potential of miR-146a in modulating the tumor microenvironment.
100 项与 ViroMissile, Inc. 相关的药物交易
100 项与 ViroMissile, Inc. 相关的转化医学