Delving into the Latest Updates on 友霖生技医药股份有限公司 with Synapse

本研究分为无缝衔接的两部分，研究主体是第二部分：VS-505的五个不同固定剂量组与碳酸司维拉姆相比，在CKD接受维持透析治疗的高磷血症患者中降低血清磷的安全性及有效性研究。根据国家药品监督管理局意见，本研究增加了第一部分25例患者的剂量爬坡试验，旨在于中国CKD接受维持透析治疗的高磷血症患者群体中评估VS-505的耐受性

开始日期2020-10-13

申办/合作机构

友霖生技医药股份有限公司

[+2]

NCT04643093 / Completed临床3期

Orient Pharma Co., Ltd.

The study is to evaluate whether the efficacy of 1PC111 is superior to pitavastatin and ezetimibe in patients with primary hypercholesterolemia or mixed dyslipidemia in the 12 week treatment period.

开始日期2020-08-01

申办/合作机构

友霖生技医药股份有限公司

NCT02704390 / Completed临床3期

An Extension Study to Evaluate the Long-term Safety and Efficacy of ORADUR®-Methylphenidate in Children and Adolescents With ADHD

The purpose of this study is to evaluate the long-term safety and efficacy of ORADUR®-Methylphenidate in children and adolescents with ADHD.

开始日期2016-01-01

申办/合作机构

友霖生技医药股份有限公司

[+1]

100 项与友霖生技医药股份有限公司相关的临床结果

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0 项与友霖生技医药股份有限公司相关的专利（医药）

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1

项与友霖生技医药股份有限公司相关的文献（医药）

Journal of Pharmacy & Pharmaceutical Sciences4区 · 医学

Progressive Steps of Polymorphic Transformation of Gabapentin Polymorphs Studied by Hot-stage FTIR Microspectroscopy

4区 · 医学

ArticleOA

作者: Lin, Shan-Yang ; Hsu, Cheng-Hung ; Ke, Wen-Ting

Purpose. The aim of this study was to determine the progressive processes of polymorphic transformation of different gabapentin (GBP) polymorphs by using hot-stage Fourier transform infrared (FTIR) microspectroscopy. Methods. Four polymorphs of GBP were previously prepared and then identified by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, FTIR microspectroscopy and X-ray powder diffractometry. A novel hot-stage FTIR microspectroscopic technique was used to investigate the progressive steps of polymorphic transformation of each GBP polymorph sealed within two pieces of KBr plates. Results. Four polymorphs (Forms I, II, III and IV) of GBP were well characterized. The GBP form I was proven to be a monohydrate, but other GBP forms II-IV were anhydrous. Different thermal-induced progressive processes and steps of polymorphic interconversion of GBP polymorphs were clearly found from the changes in the three-dimensional IR spectral contour and peak intensity by using hot-stage FTIR microspectroscopy. The results also indicate that GBP form I was dehydrated and transformed to form III, and then converted to form IV; whereas GBP forms II and III directly transformed to form IV during heating. The GBP form IV was the last polymorph before the intramolecular lactamization of GBP. Conclusion. A one-step novel hot-stage FTIR microspectroscopy was successfully applied to simultaneously and continuously investigate the progressive processes and steps of thermal-induced polymorphic interconversion of GBP polymorph in the solid state.

100 项与友霖生技医药股份有限公司相关的药物交易

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100 项与友霖生技医药股份有限公司相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

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药物(靶点)	适应症	全球最高研发状态

可乐定/奥昔布宁 ( ADRA2 x M1 receptor x M2 receptor x M3 receptor )	流涎更多	批准上市
HUEXC-030 ( CYP2E1 )	结核更多	暂停
DL-06005	黄斑变性更多	无进展
VS-505 ( HSP70 heat-shock proteins )	高磷血症更多	无进展
OP-010	入睡和睡眠障碍更多	无进展