Sirenas Marine Discovery LLC

Sirenas LLC has developed an efficient data-driven predictive metabolomics platform for the discovery and translation of nature inspired small mols. into therapeutics that address unmet medical needs.Our proprietary informatics software, Atlantis, integrates cutting-edge metabolomics and data mining approaches to interrogate chem. diverse samples, predicting the therapeutic potential of the nearly 300K unique small mols. comprising our library.Atlantis dramatically accelerates the natural product discovery process to align with modern drug development timelines, and has rapidly yielded compounds with a variety of therapeutic applications, including first-in-class small mol. therapeutics for immune modulation and infectious disease.Here, we describe the discovery of an exquisitely potent anti-malarial compound with a novel structure and likely, novel mechanism of action.The case study highlights the ability of our platform to identify extremely minor but potent metabolites within complex samples, allowing rapid isolation, synthesis, and biol. characterization of lead mols.