Delving into the Latest Updates on Centro de Ingenieria Genetica y Biotecnologia with Synapse

概览

疾病领域	数量

感染	9
免疫系统疾病	3
肿瘤	3
神经系统疾病	2
血液及淋巴系统疾病	2

排名前五的药物类型	数量

生物药	7
预防性疫苗	3
合成多肽	3
生物类似药	3
疫苗	2

排名前五的靶点	数量

HPV E7(HPV病毒E7蛋白)	1
EPO receptor(促红细胞生成素受体)	1
IFNGR(干扰素γ受体复合体)	1
GHR(生长激素受体)	1
CK2(酪蛋白激酶 II)	1

关联

29

项与 Centro de Ingenieria Genetica y Biotecnologia 相关的药物

Hib-DTP-hepatitis B vaccine(Center For Genetic Engineering And Biotechnology)

靶点-

作用机制

免疫刺激剂

在研机构

Centro de Ingenieria Genetica y Biotecnologia

原研机构

Centro de Ingenieria Genetica y Biotecnologia

在研适应症

白喉 [+4]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

古巴

首次获批日期2016-07-31

Diphtheria/tetanus/pertussis/hepatitis B virus infection vaccine(Center For Genetic Engineering And Biotechnology)

靶点-

作用机制

免疫刺激剂

在研机构

Heber Biotec SA [+1]

原研机构

Centro de Ingenieria Genetica y Biotecnologia

在研适应症

白喉 [+3]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

古巴

首次获批日期2009-12-31

Recombinant epidermal growth factor(Center For Genetic Engineering And Biotechnology)

重组人表皮生长因子(Center For Genetic Engineering And Biotechnology)

靶点

EGFR

作用机制

EGFR调节剂

在研机构

Discovery Therapeutics Caribe, LLC [+2]

原研机构

Centro de Ingenieria Genetica y Biotecnologia

在研适应症

糖尿病足 [+1]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

古巴

首次获批日期2007-09-01

100 项与 Centro de Ingenieria Genetica y Biotecnologia 相关的临床结果

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0 项与 Centro de Ingenieria Genetica y Biotecnologia 相关的专利（医药）

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288

项与 Centro de Ingenieria Genetica y Biotecnologia 相关的文献（医药）

2024-09-01·Microbiological Research

Differential nested patterns of Anaplasma marginale and Coxiella-like endosymbiont across Rhipicephalus microplus ontogeny

Article

作者: Wu-Chuang, Alejandra ; Mellor, Luis Méndez ; Mateos-Hernández, Lourdes ; Foucault-Simonin, Angélique ; Piloto-Sardiñas, Elianne ; Bello, Yamil ; Bravo, Frank Ledesma ; Fernández, Rafmary Rodríguez ; Castillo, Alier Fuentes ; Abuin-Denis, Lianet ; Rodríguez-Mallon, Alina ; Obregon, Dasiel ; Estrada-García, Mario Pablo ; Maitre, Apolline ; Paulino, Patrícia Gonzaga ; Cabezas-Cruz, Alejandro ; Gutierrez, Anays Alvarez

Understanding the intricate ecological interactions within the microbiome of arthropod vectors is crucial for elucidating disease transmission dynamics and developing effective control strategies. In this study, we investigated the ecological roles of Coxiella-like endosymbiont (CLE) and Anaplasma marginale across larval, nymphal, and adult stages of Rhipicephalus microplus. We hypothesized that CLE would show a stable, nested pattern reflecting co-evolution with the tick host, while A. marginale would exhibit a more dynamic, non-nested pattern influenced by environmental factors and host immune responses. Our findings revealed a stable, nested pattern characteristic of co-evolutionary mutualism for CLE, occurring in all developmental stages of the tick. Conversely, A. marginale exhibited variable occurrence but exerted significant influence on microbial community structure, challenging our initial hypotheses of its non-nested dynamics. Furthermore, in silico removal of both microbes from the co-occurrence networks altered network topology, underscoring their central roles in the R. microplus microbiome. Notably, competitive interactions between CLE and A. marginale were observed in nymphal network, potentially reflecting the impact of CLE on the pathogen transstadial-transmission. These findings shed light on the complex ecological dynamics within tick microbiomes and have implications for disease management strategies.

2024-09-01·Microchemical Journal

On the utility of the extracted ion chromatograms for assigning the conjugation sites and side reactions in bioconjugates synthesized by the maleimide-thiol chemistry

作者: Martinez, Olivia ; Murillo, Dhayme ; Gonzalez, Luis Javier ; Ramos-Bermudez, Pablo E. ; Fajardo, Abel ; Duran, Rosario ; Garay, Hilda Elisa ; Ulrich, Louise Kurt ; Brant, Rodrigo Soares Caldeira ; Besada, Vladimir ; Rodriguez-Mallon, Alina ; Leyva, Alejandro ; Carvalho, Paulo ; Pousa, Satomy ; Takao, Toshifumi ; Batista, Michel

Maleimide-thiol chem. is widely used in the synthesis of protein-protein conjugate vaccines.In this reaction, thiol and maleimide groups, either in the carrier protein or in the antigen mols., are linked via a thiosuccinimide linker.The assignment of the conjugation sites is key and is usually done by LC-MS/MS anal. of the conjugate proteolytic digestion, resulting in a very complex mixture of linear peptides and crosslinked peptide pairs.During proteolysis, the thiosuccinimide linker is converted to its hydrolyzed and transcyclized forms.The set of MS/MS spectra assigned to crosslinked peptide pairs contains valuable information about the conjugation sites that must be validated using objective criteria for more reliable assignment.The extracted ion chromatograms (XICs) have not previously been considered for these validation purposes.In the LC-MS/MS anal., linear peptides eluted with a single-peak XIC pattern, while the crosslinked peptide pairs with a transcyclized linker (consisting of a mixture of diastereomers) eluted with a two-peak XIC pattern in 68-100% of cases.Cross-linked peptide pairs with the hydrolyzed linker were detected with a multi-peak XIC pattern consisting of two, three and four peaks in 77%, 15% and 8% of cases, resp.The four-peak XIC pattern corresponds to crosslinked peptide pairs with two positional isomers of the hydrolyzed linker containing a mixture of diastereomers.Tandem digestions increased the anal. value of the XICs by converting the large and hydrophobic crosslinked peptide pairs, that show a single-peak XIC pattern, to more hydrophilic species eluting in multi-peak XIC patterns.XICs are easily obtained in any LC-MS/MS anal., contain valuable information about conjugation sites and side reaction detection, and are worthy of routine inclusion in bioconjugate characterization.

2024-08-01·Fish & Shellfish Immunology

PACAP binds conserved receptors and modulates cytokine gene expression and protein secretion in trout cell lines

Article

作者: Soto-Dávila, Manuel ; Wong-Benito, Valentina ; Rodríguez-Ramos, Tania ; Carpio, Yamila ; Méndez, Laura Rivera ; Dixon, Brian ; Estrada, Mario Pablo

Antimicrobial peptides (AMPs) are an alternative to antibiotics for treatment and prevention of infections with a lower risk of bacterial resistance. Pituitary adenylate cyclase activating polypeptide (PACAP) is an outstanding AMP with versatile effects including antimicrobial activity and modulation of immune responses. The objective of this research was to study PACAP immunomodulatory effect on rainbow trout cell lines infected with Aeromonas salmonicida. PACAP from Clarias gariepinus (PACAP1) and a modified PACAP (PACAP5) were tested. RT-qPCR results showed that il1b and il8 expression in RTgutGC was significantly downregulated while tgfb expression was upregulated after PACAP treatment. Importantly, the concentration of IL-1β and IFN-γ increased in the conditioned media of RTS11 cells incubated with PACAP1 and exposed to A. salmonicida. There was a poor correlation between gene expression and protein concentration, suggesting a stimulation of the translation of IL-1β protein from previously accumulated transcripts or the cleavage of accumulated IL-1β precursor. In-silico studies of PACAP-receptor interactions showed a turn of the peptide characteristic of PACAP-PAC1 interaction, correlated with the higher number of interactions observed with this specific receptor, which is also in agreement with the higher PACAP specificity described for PAC1 compared to VPAC1 and VPACA2. Finally, the in silico analysis revealed nine amino acids related to the PACAP receptor-associated functionality.

100 项与 Centro de Ingenieria Genetica y Biotecnologia 相关的药物交易

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100 项与 Centro de Ingenieria Genetica y Biotecnologia 相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

7

4

临床1期

临床2期

2

临床3期

批准上市

6

8

其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

非格司亭生物类似药(Center For Genetic Engineering And Biotechnology) ( CSF-3R )	中性粒细胞减少更多	批准上市
Diphtheria/tetanus/pertussis/hepatitis B virus infection vaccine(Center For Genetic Engineering And Biotechnology)	乙型肝炎更多	批准上市
Recombinant HBV surface antigen subunit vaccine(Center For Genetic Engineering And Biotechnology)	丁型肝炎更多	批准上市
Hib-DTP-hepatitis B vaccine(Center For Genetic Engineering And Biotechnology)	破伤风更多	批准上市
促红细胞生成素生物类似药(Center For Genetic Engineering And Biotechnology) ( EPO receptor )	贫血更多	批准上市