预约演示
更新于：2026-01-20
University of Shaoxing
更新于：2026-01-20
概览
标签
肿瘤
消化系统疾病
小分子化药
疾病领域得分
一眼洞穿机构专注的疾病领域
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公司药物应用最多的技术
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公司最常开发的靶点
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首次获批日期 |
CN119930732
专利挖掘靶点 |
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在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
NCT05559151
Effect and Mechanism of Remimazolam Benzenesulfonate on Eenhanced Recovery After Surgery in Patients Undergoing Radical Gastrectomy for Gastric Cancer
NCT05042583
Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery in Patients With Liver Lobectomy and Its Mechanism
NCT05587023
Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery of Patients Undergoing Cardiac Valve Replacement and Its Mechanism
100 项与 绍兴文理学院 相关的临床结果
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2026-02-01TALANTA
Dual fluorescence-enhanced AuAg-ZIF@Content structure cleavage-mediated ratiometric emission binding interpretable machine learning empowers biosensing
Article
作者: Wang, Yuqian ; Chen, Junyang ; Xu, Gaoxiang ; Shen, Runpu ; Cui, Huifang ; Gao, Sainan ; Fan, Lianghui ; Xu, Jianzhong ; Xiao, Zhikang
With the advancement of technology and the focus on health, biosensors have undergone a shift in focus from breakthroughs in a single area to an emphasis on improving integrated performance. Herein, aiming at two principal aspects of signal transduction and data processing in the development of fluorescent material-based biosensors, a generalized biosensing platform was developed that integrates dual-enhanced fluorescent materials, ratiometric detection, and interpretable machine learning algorithms. Initially, AuAg-ZIF was synthesized, whose fluorescence properties were doubly enhanced relative to AuNCs through the anti-galvanic reaction occurring between surface Ag(I) and core Au(0) and the confinement effect of ZIF-8. Furthermore, AuAg-ZIF@CD was prepared by encapsulating CD into AuAg-ZIF using the inner cavity of ZIF-8, which enables ratiometric fluorescence detection of different targets by the degradation responsiveness of ZIF-8 to acids, ATP, and phosphates. Subsequently, an interpretable machine learning prediction algorithm was constructed for automated data processing, which determines target concentrations within 5 s following image acquisition. Finally, to validate the platform for practical application, we achieved immediate, intelligent and accurate detection of glucose concentration-mediated ratiometric fluorescence changes in AuAg-ZIF@CD (R2 = 0.95) based on AuAg-ZIF@CD degradation reactivity to acid. This was successfully confirmed in 48 clinical samples (AUC = 0.988).
2026-02-01NEUROPHARMACOLOGY
Olfactory ensheathing cells reduce trigeminal neuralgia pain and anxiety by suppressing P2X7R-mediated A1 Astrocyte activation in mice
Article
作者: Li, Zhiwei ; Li, Mengyun ; Lin, Hui ; Xu, Lili ; He, Lingyan ; Shan, Yue ; Lu, Jiafeng ; Shao, Xian ; Chen, Zhonghua
Trigeminal neuralgia (TN), the most intense chronic pain syndrome affecting the craniofacial region, is closely associated with neuroinflammation and aberrant glial-neuron interactions. Our preliminary studies demonstrated that implantation of exogenous olfactory ensheathing cells (OECs) alleviates TN, suppresses P2X7 receptor (P2X7R) expression in neural tissues, and ameliorates neuroinflammatory responses. However, specific mechanisms underlying these effects remain unclear. This is the first study to investigate whether exogenous OECs transplantation alleviates TN-induced pain and anxiety symptoms by inhibiting P2X7R to suppress the activation of A1 astrocytes. In vitro, astrocytes were modeled using the C8D1A cell line. OEC-conditioned medium suppressed lipopolysaccharide-induced astrocyte activation and downregulated the expression of A1 astrocyte markers by inhibiting P2X7R activation. In vivo, a TN model was established in C57BL/6 mice (regardless of gender) via distal ligation of the infraorbital nerve. An adeno-associated virus (AAV) carrying an astrocyte-specific promoter was used to selectively silence P2X7R in astrocytes of the right medial habenula (MHb). Both OECs transplantation and P2X7R-AAV partially reduced the expression of A1 reactive astrocyte markers in the MHb and partially alleviated pain and anxiety-like behaviors in mice. Meanwhile, the combination of OECs transplantation and P2X7R-AAV treatment significantly ameliorated pain and anxiety symptoms in TN mice. This study demonstrates that OECs may alleviate pain and anxiety in TN mice by targeting P2X7R to inhibit A1 reactive astrocyte activation and modulate astrocyte reactivity in the MHb. By combining in vitro and in vivo approaches, this study provides experimental evidence to support a combined cellular-molecular therapeutic strategy for TN.
2026-01-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Responsive structural color materials for sensing strain, water, and camouflage
Article
作者: Yang, Dongpeng ; Cao, Cong ; Huang, Shaoming ; Zhang, Zekun ; Ma, Dekun ; Hu, Xia ; Xiao, Yingbo
Chameleon skins capable of dynamically adjusting and reversibly turning on-off their structural colors have attracted great interest. However, most chameleon-inspired responsive structural color materials (RSCMs) can only mimic the dynamic color and show poor stability, stretchability (strain <68 %), and responsive speed (< 1 nm/ms), significantly restricting their practical applications. Here, force/water-responsive RSCMs that can independently imitate dynamic and on-off structural colors have been fabricated by 1) non-close-assembling silica particles into the 4-hydroxybutyl acrylate (HBA) to generate swellable hydrophilic photonic crystals (PCs), 2) swelling the PCs by HBA, and 3) photopolymerizing swelled PCs. Compared to traditional RSCMs, the RSCMs possess no solvent and super-large lattice distances with a high elastic modulus, resulting in outstanding stability and mechanochromism, involving large strain (0-110 %), large Δλ (253 nm), ultrafast responsiveness (6.7 nm/ms), and excellent reversibility (> 500 times). Moreover, the RSCMs exhibit an unconventional water-responsiveness of reversibly turning on-off color under the dry-water states, due to the refraction mismatching-matching. RSCMs-based trip-mode camouflage was realized, showing their great potential in wireless sensing, optical devices, anticounterfeiting, etc.
2026-01-11
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100 项与 绍兴文理学院 相关的药物交易
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