Delving into the Latest Updates on 福建省微生物研究所 with Synapse

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2

项与福建省微生物研究所相关的药物

FW-04-806

靶点

CDC37 x HSP90

作用机制

CDC37拮抗剂 [+1]

在研机构-

原研机构

福建医科大学附属协和医院 [+1]

在研适应症-

非在研适应症

乳腺癌

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

FIM-X13

靶点

mTOR

作用机制

mTOR抑制剂

在研机构-

原研机构

福建省微生物研究所

在研适应症-

非在研适应症

胃癌

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与福建省微生物研究所相关的临床结果

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0 项与福建省微生物研究所相关的专利（医药）

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203

项与福建省微生物研究所相关的文献（医药）

2025-01-20·The Natural Products Journal

Qualitative and Structural Insights into Levantilides C/D via LC-MS

作者: Zhou, Jingming ; Zhou, Jian ; Jiang, Hong ; Chen, Nan-nan ; Zhao, Wei ; Wu, Bin

Abstract:In this study, we utilized high-performance liquid chromatography coupled with quadrupole- time of flight mass spectrometry (HPLC-Q-TOF/MS/MS), combined with electrospray ionization in the positive mode (ESI+), to establish a comprehensive framework for chromatographic separation and mass spectrometric detection. The primary focus was on performing collision-induced dissociation (CID) experiments on levantilide D, a newly identified macrolide, and its well-established analog, levantilide C, in order to elucidate their mass spectral fragmentation patterns. The results revealed that the cleavage patterns of levantilides were successfully characterized when ionized in the positive mode. These fragmentation profiles provide valuable insights for the rapid and accurate structural identification and quantitative analysis of levantilides when they often occur in trace amounts. Furthermore, this methodology offers crucial technical references for environmental pollutant monitoring and pharmacokinetic investigations for levantilide-related compounds.

2024-10-11·The Natural Products Journal

Polyene Macrolactams from Marine Micromonospora sp.

作者: Chen, Xiuming ; Zhou, Jian ; Wu, Bin ; Sun, Fei ; Lin, Ru ; Butt, Usman-Dawood ; Jiang, Hong ; Jiang, Honglei ; Zhou, Jingming ; Wang, Yi-nuo ; Zhao, Wei

Introduction:Three novel macrolactams, FW8-1 (1), FW8-4 (2), and FW60-20 (3), were isolated from a culture of Micromonospora sp. The structures of these compounds were elucidated using Mass Spectrometry (MS) and comprehensive Nuclear Magnetic Resonance (NMR) analyses.Methods:The relative configurations of compounds 1-3 were assigned through theoretical calculations of their NMR spectra.objective:The objective is to obtain PMLs with novel structures and to characterize and evaluate them.Results:The isolation and determination of the relative configurations of these macrolactams have provided fresh perspectives on the biosynthetic pathways, leading to the formation of polyene macrolactams.Conclusion:Further, virtual screening and bioactivity predictions have suggested compounds 1-3 to possess potential anti-tumor, anti-inflammatory, and neuroprotective properties.

2024-10-10·The Natural Products Journal

Antimicrobial Macrolide Levantilide D from Rare Marine Micromonospora sp.

作者: Jiang, Hong ; Lin, Ru ; Zhou, Jian ; Wu, Bin ; Jiang, Honglei ; Zhao, Wei ; Zhao, Meilu ; Zhou, Jingming ; Ge, Yichao

Introduction:One new levantilide D (2) with a 20-membered macrolide, along with one known levantilide C (1), was isolated from a rare marine actinomycetes Micromonospora sp. (FIMYZ52).Method:The structural elucidation of the compounds was based on integrated analyses involving 1D and 2D NMR spectroscopy and HR-ESI-MS.Result:The relative and absolute configurations of compounds 1 and 2 were ascertained by integrating multispectral ROESY and NOESY information from analogs in conjunction with theoretical TDDFT-ECD calculations. Levantilide D (2) exhibited antibacterial activity against Staphylococcus aureus.Conclusion:A plausible biosynthetic pathway of the macrolide compounds (1-2) was proposed.conclusion:The structure of levantilide D in this study is characterized by a 20-membered macrolide structure with moderately long branched aliphatic chains containing hydroxyl or ketone groups. Macrolides are a class of antibiotics that are widely used to treat a variety of bacterial infections. This structure is crucial for their antibacterial activity. The variations in the lactone ring structure and the attached fatty chains have given rise to different generations of macrolides with varying properties, including antibacterial activity.

100 项与福建省微生物研究所相关的药物交易

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100 项与福建省微生物研究所相关的转化医学

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