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Transdermal Lisuride: a Double-blind, Randomized, Active- and Placebo-controlled Multi-centre Phase III Efficacy Trial for the Treatment of Patients With Restless Legs Syndrome (RLS)

The objective of this trial is to compare an individually optimized dose of the lisuride TTS patch against placebo and against an individually optimized dose of oral ropinirole (active- and placebo-controlled design) in idiopathic and uremic RLS patients with regard to efficacy, safety, and quality of life.

开始日期-

申办/合作机构

axxonis Pharma AG

EUCTR2006-003732-30-DE / Unknown statusN/A

Transdermal Use of Lisuride in Early Parkinson´s Disease: A double blind, randomized, Placebo and Pramipexole controlled study to evaluate the efficacy and safety of Lisuride TTS - TULEP 1

开始日期2007-01-31

申办/合作机构

axxonis Pharma AG

NCT00408915 / Completed临床3期

Double-blind, Placebo-controlled, Randomized, Multicentre Phase II/III Study to Evaluate the Efficacy and Safety of Lisuride, Applied Subcutaneously by Means of a Minipump in Patients With Advanced Parkinson's Disease Refractory to Conventional Oral Therapy

The aim of the study is to evaluate the long-term efficacy, local tolerability and safety of Lisuride applied as subcutaneous infusion compared to placebo in patients with advanced Parkinson's disease with motor fluctuations and "OFF" periods refractory to conventional treatment.

开始日期2006-07-01

申办/合作机构

axxonis Pharma AG

100 项与 axxonis Pharma AG 相关的临床结果

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0 项与 axxonis Pharma AG 相关的专利（医药）

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项与 axxonis Pharma AG 相关的文献（医药）

2009-10-01·Journal of Medicinal Food4区 · 医学

Determination of Acute Toxicity of the Aqueous Extract of Potentilla erecta (Tormentil) Rhizomes in Rats and Mice

4区 · 医学

Article

作者: Kravtsova, Aleftina ; Balashov, Lev ; Vasiliev, Andrei ; Krasnogorsky, Ivan ; Latté, Klaus Peter ; Shushunov, Sergei

Potentilla erecta, the tormentil, and its rhizome extracts have been known for a long time in traditional medicine as a remedy for the treatment of inflammations, wounds, and gastrointestinal disorders. Tormentil rhizomes have also been used as part of alcoholic beverages in Germany, the Ukraine, and Russia. Acute toxicity of an aqueous P. erecta rhizome extract was evaluated with a single dose administered by the intragastric route to rats and mice in dosages of 2.5 g/kg and 6.8 g/kg of body weight, respectively. Further, a single dose of this extract was applied intraperitoneally to rats and mice in dosages of 3.8 and 14.5 g/kg of body weight, respectively. After an observation period of 2 weeks after intragastric administration and 3 days following intraperitoneal administration, no mortality or any changes in appearance, behavior, or body weight occurred for both rats and mice in the high dosages mentioned. Macroscopic and microscopic studies of the internal organs of these rodents revealed no pathological changes. The data are in line with the long-time traditional use of P. erecta rhizome extracts and results from recent clinical trials in which no signs of any toxic effects have been known after the administration of a P. erecta rhizome extract for the treatment of ulcerative colitis in adults and rotavirus-induced diarrhea in children. Thus P. erecta rhizome extracts should be considered safe with respect to acute toxicity when applied to humans.

100 项与 axxonis Pharma AG 相关的药物交易

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100 项与 axxonis Pharma AG 相关的转化医学

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