Delving into the Latest Updates on Academy of Scientific & Innovative Research with Synapse

概览

疾病领域	数量

内分泌与代谢疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	3

排名前五的靶点	数量

ST8SIA4	1
ERβ(雌激素受体β)	1

关联

3

项与 Academy of Scientific & Innovative Research 相关的药物

compound 24b(CIMAP)

靶点

ERβ

作用机制

ESR2拮抗剂

在研机构

Academy of Scientific & Innovative Research [+1]

原研机构

Academy of Scientific & Innovative Research [+1]

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

PSTi8

靶点

ST8SIA4

作用机制

ST8SIA4 inhibitors

在研机构

Academy of Scientific & Innovative Research

原研机构

Academy of Scientific & Innovative Research

在研适应症

糖尿病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Esculetin

靶点-

作用机制-

在研机构

Academy of Scientific & Innovative Research [+1]

原研机构-

在研适应症

动脉粥样硬化

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Academy of Scientific & Innovative Research 相关的临床结果

登录后查看更多信息

0 项与 Academy of Scientific & Innovative Research 相关的专利（医药）

登录后查看更多信息

14,301

项与 Academy of Scientific & Innovative Research 相关的文献（医药）

2025-02-01·Optics & Laser Technology

Self-bias Mo–Sb–Ga multilayer photodetector encompassing ultra-broad spectral response from UV–C to IR–B

作者: Dash, Ajit ; Vashishtha, Pargam ; Gupta, Govind ; Walia, Sumeet

Achieving an ultra-broad spectral response in a self-bias detector is a formidable challenge that persists in optoelectronics that necessitates innovative solutionsWe propose a unique ultra-broadband photodetecting device, utilizing a multilayer structure comprising Molybdenum Di-sulfide (MoS₂), Antimony Tri-selenide (Sb₂Se₃), and Gallium Nitride (GaN), which exhibits the unique capability of detecting photons without applied bias.The fabricated device demonstrates exceptional sensitivity to a wide range of illumination wavelengths, spanning from UV-C (UV-C) to IR-B (IR-B).The design detector displays the highest photo-responsivity of 665 mAW^-1 in photovoltaic mode and 3.89 x 10⁵ mAW^-1 in photoconductive mode.The designed detector also exhibits a minimal dark current of 90 nA and an extremely weak signal detection capability of ∼12 femto watt-hertz^-1/2 at 6 V bias.Addnl., the thermal stability of the MoS₂-Sb₂Se₃-GaN (Mo-Sb-Ga) multi-layer-based self-bias detector was explored.Under the self-bias conditions, the photodetector exhibits a stable behavior up to 250°C with a peak responsivity of 635 mAW^-1.The thermal durability of the self-bias ultra-broadband photodetector indicates excellent potential for developing futuristic optoelectronic devices.Further, the performance of the developed detector was examined using Technol. Computer-Aided Design (TCAD) simulations, providing valuable insights into the device behavior and the transport of photo-generated carriers, enhancing our understanding of the device operation and enabling performance optimization for diverse applications.

2025-02-01·The Natural Products Journal

Exploration of the Molecular Mechanism Underlying the Antidiabetic Activity of a Northeast Indian Plant Zingiber rubens Roxb. through Modulation of PKC Phosphorylation

作者: Devroy, Piyali ; Ghosh, Suparna ; Bhowmik, Manas ; Chatterjee, Suraj Kumar ; Das, Sujit ; Haldar, Pallab Kanti ; Jana, Sandipan ; Gayen, Srijon ; Bala, Asis

Background:Zingiber rubens Roxb., a new species of the Zingiberaceae family, is found profoundly in the Northeastern region of India. It is a rhizomatous geophyte and grows primarily in the seasonally dry tropical biome native to Indo-China regimens.Objective:The aim is to research the root part of this plant to discover active constituents and evaluate the molecular mechanism of antidiabetic activityMethods:The hydroalcoholic root extract of this plant (HAZR) was evaluated for in-vitro antioxidant assays α-amylase and α-glucosidase inhibition assay. Further, the antidiabetic activity assay was evaluated, exploring the molecular mechanism for modulating oxidative stress in tissue biochemical parameters and HbA1c. To explore the molecular mechanism, we also investigated the inhibition assay of protein kinase C (PKC) phosphorylation in mouse peritoneal macrophages.Results:The experiments' results helped to conclude that HAZR has potent antioxidant and antidiabetic activity and could have been embedded with potent active molecules. They also revealed the mechanism of action as inhibition of PKC phosphorylation, meriting further studies.Conclusion:The present study revealed that HAZR demonstrated its antidiabetic activity against diabetic animal models through oxidative stress-mediated PKC and TGF-β regulation in diabetic individuals.

2025-01-01·Journal of Aerospace Engineering

Virtual Frequency Fusion Technique: Detecting Multiple Damages via Broadband Lamb Wave Field Using Scanning Laser Vibrometry

作者: Kannusamy, M. ; Sasmal, Saptarshi ; Kapuria, Santosh

100 项与 Academy of Scientific & Innovative Research 相关的药物交易

登录后查看更多信息

100 项与 Academy of Scientific & Innovative Research 相关的转化医学

登录后查看更多信息