Delving into the Latest Updates on Universidad Católica del Norte with Synapse

概览

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

Nrf2(核转录因子的激活红细胞2相关因子)	1

关联

1

项与 Universidad Católica del Norte 相关的药物

Alginate oligosaccharides

靶点

Nrf2

作用机制

Nrf2刺激剂

在研机构

Universidad Católica del Norte [+1]

原研机构-

在研适应症

胃病 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

1

项与 Universidad Católica del Norte 相关的临床试验

NCT05069090 / CompletedN/AIIT

Effect of COVID-19 Lockdown on Alcohol and Tobacco Use in Two Chilean Universities: a Difference-in-difference Analysis

This is a longitudinal study of participants from two university communities in Chile. The primary objective is to examine the effect of a regional lockdown on alcohol and tobacco use, using a difference-in-difference analysis to obtain causal estimates of these COVID-19 policies.

开始日期2020-06-03

申办/合作机构

University of La Frontera

[+1]

100 项与 Universidad Católica del Norte 相关的临床结果

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0 项与 Universidad Católica del Norte 相关的专利（医药）

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6,592

项与 Universidad Católica del Norte 相关的文献（医药）

2024-12-31·Cogent Social Sciences

Characteristics of potential buyers of low-pollution vehicles: the case of Santiago de Chile

作者: Urrutia-Mosquera, Jorge ; Flórez-Calderón, Luz

2024-12-31·Cogent Social Sciences

Perception of entrepreneurs in the processes of innovation and digitization of the supply chain: a study applied in small restaurants

作者: Ortegon-Lopez, Erika Jazmin ; Garcia-Buitrago, Maria Alejandra ; Areiza-Padilla, Jose Andres ; Galindo-Becerra, Tatiana ; Mariño-Parra, Yeny Paola ; Barajas-Portas, Karla ; Veas-González, Ivan

2024-12-01·Cryobiology

Cytoskeleton adaptation to stretchable surface relaxation improves adherent cryopreservation of human mesenchymal stem cells

Article

作者: Meiser, Ina ; Schmidt, Katharina ; Neubauer, Julia C ; Gerlach, Thomas ; Böse, Holger ; Lautenschläger, Franziska ; Lemmer, Katja ; Stracke, Frank ; Le Harzic, Ronan ; Zimmermann, Heiko ; Altmaier, Saskia ; Ehrlich, Johannes ; Speicher, Anna Martina ; Uhl, Detlev

Adherent cell systems are usually dissociated before being cryopreserved, as standard protocols are established for cells in suspension. The application of standard procedures to more complex systems, sensitive to dissociation, such as adherent monolayers, especially comprising mature cell types or tissues remains unsatisfactory. Uncontrolled cell detachment due to intracellular tensile stress, membrane ruptures and damages of adhesion proteins are common during freezing and thawing of cell monolayers. However, many therapeutically relevant cell systems grow adherently to develop their native morphology and functionality, but lose their integrity after dissociation. The hypothesis is that cells on stretchable substrates have a more adaptable cytoskeleton and membrane, reducing cryopreservation-induced stress. Our studies investigate the influence of stretchable surfaces on the cryopreservation of adherent cells to avoid harmful dissociation and expedite post-thawing cultivation of functional cells. A stretching apparatus for defined radial stretching, consisting of silicone vessels and films with specific surface textures for cell culture, was developed. Adherent human umbilical cord mesenchymal stem cells (hUC-MSCs) were cultivated on a stretched silicone film within the vessel, forming a monolayer that was compressed by relaxation, while remaining attached to the relaxed film. Compressed hUC-MSCs, which were cryopreserved adherently showed higher viability and less detachment after thawing compared to control cells without compression. Within three to seven days post-thawing, the hUC-MSCs recovered, and the monolayer reformed. These experiments support the hypothesis that cryopreservation success of adherent cell systems is enhanced by improved adaptability of the cytoskeleton and cell membrane, opening up new approaches in cryobiotechnology.

100 项与 Universidad Católica del Norte 相关的药物交易

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100 项与 Universidad Católica del Norte 相关的转化医学

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