Alginate oligosaccharides(Alginate oligosaccharides) - 药物靶点：Nrf2_在研适应症：肠炎，急性肾损伤，胃病_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

Nrf2

作用方式

刺激剂

作用机制

Nrf2刺激剂(核转录因子的激活红细胞2相关因子刺激剂)

治疗领域

消化系统疾病泌尿生殖系统疾病其他疾病

在研适应症

肠炎急性肾损伤胃病+ [1]

非在研适应症-

原研机构-

在研机构

Universidad Católica del Norte

中山大学

大连民族学院

+ [1]

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

关联

100 项与 Alginate oligosaccharides 相关的临床结果

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100 项与 Alginate oligosaccharides 相关的转化医学

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100 项与 Alginate oligosaccharides 相关的专利（医药）

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60

项与 Alginate oligosaccharides 相关的文献（医药）

2025-11-01·PLANT PHYSIOLOGY AND BIOCHEMISTRY

Alginate oligosaccharide alleviates chilling injury in postharvest peach fruit via regulating antioxidant and membrane lipid metabolisms

Article

作者: Ye, Jianfen ; Ding, Phebe ; Xu, Feng ; Jiang, Shu ; Chen, Yi ; Shao, Xingfeng ; Wei, Yingying ; Wang, Jing

Peach fruit are highly susceptible to chilling stress during cold storage. This study evaluated the effects of alginate oligosaccharide (AOS) in enhancing chilling tolerance in 'Hujingmilu' peaches. Treatment with 0.1 % AOS for 10 min significantly alleviated the CI symptoms during 28 d of storage at 5 °C. This was confirmed by the lower browning index, reduced content of malondialdehyde (MDA) and hydrogen peroxide (H₂O₂), and higher levels of proline. Meanwhile, the gene expressions and enzyme activities of peroxidase (POD), lipoxygenase (LOX), phospholipase C (PLC) and phospholipase D (PLD) were significantly down-regulated in AOS-treated peaches, while catalase (CAT) and ascorbate peroxidase (APX) were significantly up-regulated. Thus, AOS can be used as a novel marine-derived bio-preservative to alleviate the CI of peach fruit by regulating the antioxidant and membrane lipid metabolisms.

2025-09-01·Journal of Advanced Research

Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota

Article

作者: Yang, Shaoqing ; Li, Tao ; Jiang, Zhengqiang ; Jiang, Jun ; Xu, Yuncong ; Yan, Qiaojuan

INTRODUCTION:

Functional oligosaccharides may provide physiological benefits through several different mechanisms. However, the specific mechanisms of alginate oligosaccharides (AOSs) for the improvement of obesity remain unclear.

OBJECTIVES:

The study aimed to evaluate the effects of AOSs with degrees of polymerization (DP) 2-4 on obesity and reveal the underlying mechanism.

METHODS:

Mice models of obesity prevention and treatment were used to determine the effects of AOSs on obesity. An antibiotic intervention was used to determine the role of gut microbiota. The therapeutic effect of intraperitoneal injection of AOSs on obesity was further explored.

RESULTS:

AOSs treatment (1, 000 mg/kg) could prevent and treat obesity, and the effects were comparable to that of an anti-obesity drug orlistat. AOSs treatment effectively reversed serum metabolic profiling, reduced lipid absorption in the small intestine and improved hepatic lipid metabolism disorders. The treatment also ameliorated systemic low-grade inflammation and oxidative stress, increased energy expenditure and improved mitochondrial function in brown adipose tissue. Moreover, broad-spectrum antibiotic intervention did not abrogate AOS-induced improvement in ameliorating obesity and intraperitoneal injection of AOSs ameliorated metabolic disorders, which highlighted that the ameliorative effect of AOSs on obesity might not be primarily dependent on gut microbiota.

CONCLUSION:

Our findings provided first evidence that AOSs could prevent and treat obesity by reducing systemic low-grade inflammation and oxidative stress, and increasing brown adipose tissue energy expenditure, rather than regulating gut microbiota.

2025-06-01·LIFE SCIENCES

Activation of mannose receptor C type 1 in macrophages improves renal fibrosis through mediating fibronectin endocytosis

Article

作者: Long, Luosha ; Chen, Wei ; Wang, Minghui ; Lyu, Qianqian ; Yuan, Xi ; Huang, Meiying ; Liu, Weizhi ; Guo, Xiangdong ; Wang, Weidong ; Li, Suchun ; Wu, Xinyan ; Li, Meng ; Liang, Baien ; Liu, Zhende ; Li, Chunling

AIMS:

Excess extracellular matrix (ECM) deposition is the characteristic of renal fibrosis, owing to the imbalance between synthesis and degradation. Fibronectin could regulate the deposition of other ECM, thus plays a crucial role in the progression of renal fibrosis. Mannose receptor C type 1 (MRC1), largely expressed on macrophages, owns an extracellular fibronectin type II domain that binds to and internalizes collagen and thus involves in fibrosis modulation. The purpose of the present study was to investigate whether MRC1 participates in the internalization of fibronectin and whether alginate oligosaccharides (AOSC), a degradation product of alginate, has beneficial effects in the resolution of renal fibrosis via MRC1.

MATERIALS AND METHODS:

Renal fibrosis models were constructed by unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion injury (UIRI) in MRC1-WT and MRC1-KO mice. RAW264.7 cells were treated with TGF-β1 to induce pro-fibrotic responses. Expression of fibrotic markers and fibronectin endocytosis were examined.

KEY FINDINGS:

MRC1 gene knockout aggravated renal fibrosis in UUO and UIRI models. Inhibition of MRC1 exacerbated TGF-β1-induced pro-fibrotic responses in RAW264.7 cells. MRC1 regulated integrin β1-mediated fibronectin endocytosis through Arp2/3-Kindlin-2 signaling pathway. AOSC improved renal fibrosis by increasing MRC1 expression and endocytosis of fibronectin.

SIGNIFICANCE:

Our findings highlight the importance of MRC1 and fibronectin endocytosis in the development of renal fibrosis, suggesting that activation of MRC1 by AOSC is probably a therapeutic option to delay the progress of kidney fibrosis.

100 项与 Alginate oligosaccharides 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肠炎	临床前	中国	大连民族学院	2025-05-14
急性肾损伤	临床前	中国	中山大学	2025-04-22
胃病	临床前	智利	Universidad Católica del Norte	2024-05-20
衰老	临床前	中国	青岛大学附属医院	2024-02-19