The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication.

开始日期2025-04-26

申办/合作机构

University of California, Los Angeles

[+3]

NCT06535373

/ RecruitingN/AIIT

Restrict and Strengthen: Unraveling the Impact of Blood Flow Restriction Training on Upper Extremity Grip Strength

The primary objective of this prospective study is to investigate the effects of Blood Flow Restriction (BFR) training compared to traditional low-weight resistance training on grip strength in young adults.
Despite the growing interest in BFR training and its potential benefits, there is limited research specifically investigating its impact on grip strength. Understanding the effects of BFR training on grip strength could have significant implications for individuals seeking to optimize their grip performance, rehabilitation settings, and sports performance enhancement. Additionally, examining the safety and efficacy of BFR training for this specific outcome will contribute valuable insights to the scientific community.

开始日期2024-08-19

申办/合作机构

Casa Colina Centers for Rehabilitation, Inc.

[+1]

NCT06004219

/ RecruitingN/AIIT

Peer Support in Patients With Diabetic Foot Ulceration

The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation are unevenly patterned in terms of racial/ethnicity, socioeconomic status, health insurance, and geographic area. The project will identify opportunities to reduce health disparities among economically marginalized patients regarding DFU outcomes.

开始日期2023-11-21

申办/合作机构

Casa Colina Centers for Rehabilitation, Inc.

[+4]

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2016-12-01·Neuromodulation: Technology at the Neural Interface2区 · 医学

Spinal Cord Stimulation (SCS)—The Implantable Systems Performance Registry (ISPR)

2区 · 医学

Article

作者: Roediger, Mollie P ; Mogilner, Alon Y ; Sasaki, John T ; Schultz, David M ; Stromberg, E Katherine ; Wells, Michelle D ; Calodney, Aaron K ; Konrad, Peter E ; Weaver, Todd W

OBJECTIVESThe Implantable Systems Performance Registry (ISPR) was created to monitor the product performance of Medtronic Spinal Cord Stimulation (SCS) and implanted intrathecal drug infusion systems available in the United States.MATERIALS AND METHODSData were collected on 2605 patients from 44 centers from various geographic regions across the United States implanting and following patients with SCS systems between June 25, 2004 and January 31, 2014. Actuarial life table methods are used to estimate device performance over time. Of the 2605 patients, 1490 (57.2%) were female, 1098 (42.1%) were male and 17 (0.7%) did not provide gender data. The average age at enrollment was 56.3 years (range: 4-97, SD = 14.3) and average follow-up time was 20.1 months (SD = 22.5).RESULTSCurrently the estimates of device survival from neurostimulator-related events exceed 97% for all neurostimulator models across the applicable follow-up time points and all applicable extension models had greater than 95% survival from extension events. The majority of product performance events were lead-related. At 5 years of follow-up, all applicable lead families, with the exception of the Pisces-Quad LZ family, had greater than 75% survival from lead events.CONCLUSIONSThe ISPR is designed to serve as an ongoing source of system and device-related information with a focus on "real-world" safety and product performance. ISPR data continue to be used to guide future product development efforts aimed at improving product reliability and quality.

2012-01-01·Rehabilitation Nursing4区 · 医学

Comparison of Fallers and Nonfallers at an Inpatient Rehabilitation Facility: A Retrospective Review

4区 · 医学

Article

作者: Redman-Bentley, Donna ; Kaplan, Stephanie ; Kwan, Frances ; Hudson-McKinney, Mary ; Rosario, Emily R

Patients in an inpatient rehabilitation facility (IRF) are at increased fall risk. However, little IRF research has focused on fall risk.PURPOSEThe purpose of this study was to retrospectively examine differences between 35 patients who fell and 35 who did not during their IRF stay .METHODThe following admission data were compared: age, gender, diagnosis, Morse Fall Scale score, and 18 Functional Independence Measure (FIM) scores. Independent t-tests were conducted for age and FIM scores, Mann-Whitney test was conducted for Morse scores, and chi-square tests were conducted for gender and diagnosis to examine differences between fallers and nonfallers.FINDINGSThere were no significant differences between groups for age, gender, diagnosis, or Morse scores. However, there were significant differences for 12 FIM items, and FIM Motor, Cognitive, and Total scores.FINDINGSThe results suggest that the Morse Scale may not be the most appropriate tool for assessing fall risk in an IRF.CONCLUSIONS AND CLINICAL RELEVANCEDecisions about fall risk should consider admission FIM scores.

2007-05-01·Current Medical Research and Opinion

Comment and Reply on:Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant pain

Letter

作者: Ross, Edgar ; David Haddox, J. ; Nicholson, Bruce ; Sasaki, John ; Weil, Arnold ; Crudele, Nancy

A polemic in response to Crudele and Haddox (Current Medical Research and Opinion, 2007, 23, 5, 1053-1054) is presented.Crudele and Haddox raised some issues regarding the authors' study entitled "Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant pain".The first issue is related to the references supporting the observation that patients taking controlled-release oxycodone for chronic nonmalignant pain may require dosing intervals less than every 12 h, and the second concerns the methodol. of the current study, whereby, during the first 12 wk of the study, patients whose dose had been up-titrated once were switched to a more frequent dosing schedule from once-daily to twice-daily dosing for polymer-coated extended-release morphine sulfate and from twice-daily to three-times-daily dosing for CRO.The authors agree that the efficacy and safety of CRO used at less than every 12 h has been well documented in patients with chronic pain.However, evidence based on clin. reports and patient usage studies indicates that a substantial proportion of patients are prescribed or utilize a more frequent dosing schedule.

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