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概览

疾病领域	数量

肿瘤	2
免疫系统疾病	1
神经系统疾病	1

排名前五的药物类型	数量

小分子化药	3
未知	1

排名前五的靶点	数量

RORγt(视黄酸相关孤儿受体γt)	1

关联

5

项与 Krish Biotech Research Pvt Ltd. 相关的药物

KBR1001

靶点

RORγt

作用机制

RORγt抑制剂

在研机构

Krish Biotech Research Pvt Ltd.

原研机构

Krish Biotech Research Pvt Ltd.

在研适应症

自身免疫性疾病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

KBR-3001

靶点-

作用机制-

在研机构

Krish Biotech Research Pvt Ltd.

原研机构

Krish Biotech Research Pvt Ltd.

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

KBR-4001

靶点-

作用机制-

在研机构

Krish Biotech Research Pvt Ltd.

原研机构

Krish Biotech Research Pvt Ltd.

在研适应症

疼痛

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

100 项与 Krish Biotech Research Pvt Ltd. 相关的临床结果

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0 项与 Krish Biotech Research Pvt Ltd. 相关的专利（医药）

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2

项与 Krish Biotech Research Pvt Ltd. 相关的文献（医药）

2020-01-01·Environmental Monitoring and Assessment4区 · 环境科学与生态学

Optimization of QuPPe approach and validation of analytical method for estimation of validamycin from grain, paddy husk, and soil by HPLC-ESI-MS/MS-based method

4区 · 环境科学与生态学

Article

作者: Behera, Prabhat Kumar ; Moharana, Alok Kumar ; Sahu, Rajanikanta ; Subudhi, Bharat Bhusan ; Muduli, Nihar Ranjan

Validamycin is the most active component of the antibiotic and antifungal validamycin complex. Since it is widely used to protect rice crops, its persistence in soil and rice matrices may affect the quality and the health of the consumer. Methods for its estimation from soil matrices are not available. Besides, its analysis from complex matrices including grain and paddy husk is challenging. So very few reliable analytical methods are available for its residue analysis. Thus, we aimed to develop a new QuPPe technique and new HPLC-ESI-MS/MS analytical method for the estimation of validamycin in grain, paddy husk, and soil. The QuPPe method was validated with a linearity range of 0.00101 to 0.10134 μg/mL. The LOQ of validamycin in grain, paddy husk, and soil was 1.01013 μg/kg and the retention time was 5.62 min. These results will be helpful in further analysis of food safety and environmental pollution.

Indian Journal of Scientific Research

Subacute 28 days repeated toxicity assessment of thymoquinone (volatile oil of black seed) in Wistar rats

作者: Alam, Mehtab ; Galav, Vikas

Thymoquinone is a major active principle of Nigella sativa (volatile oil of black seed or kalonji Seed) and constitutes about more than 30 % its volatile oil.The kalonji seed are believed to be commonly used as natural remedy for all disease except death.The study was subjected to subacute toxicol. testing to dose dependant toxicity to use as traditional medicine and establishing dose criteria to human being.Thymoquinone orally administered to male and female wistar rat at dose level of 2.5, 5.0, 10.0 mg/kg body weight for 28 days repeatedly, did not produce any sign of toxicity, mortality, pathol. and blood parameters changes.It is suggested that thymoquinone at higher dose level is well tolerated by male and female rats.The Higher dose of thymoquinone 10.0 mg/kg body weight determined to be no observed adverse effect level (NOAEL).

100 项与 Krish Biotech Research Pvt Ltd. 相关的药物交易

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100 项与 Krish Biotech Research Pvt Ltd. 相关的转化医学

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管线布局

2024年12月21日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

3

1

临床前

其他

1

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当前项目

药物(靶点)	适应症	全球最高研发状态

KBR1001 ( RORγt )	自身免疫性疾病更多	临床前
KBR-3001	肿瘤更多	药物发现
KBR-4001	疼痛更多	药物发现
KBR-3002	肿瘤更多	药物发现
KBR-2001 ( GPR120 )	2型糖尿病更多	无进展