Defence Institute of Physiology and Allied Sciences (Defence Institute of Physiology and Allied Sciences)

概览

排名前五的药物类型	数量

化学药	1

关联

1

项与 Defence Institute of Physiology and Allied Sciences 相关的药物

NIM-76

靶点-

作用机制

细胞膜调节剂

在研机构

Defence Institute of Physiology and Allied Sciences

[+1]

原研机构

Defence Institute of Physiology and Allied Sciences

在研适应症

怀孕

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

印度

首次获批日期2001-03-05

1

项与 Defence Institute of Physiology and Allied Sciences 相关的临床试验

CTRI/2022/09/045812

/ Not yet recruiting临床3期

Study of human microbiome and probiotic supplementation under extreme environmental conditions.

开始日期2023-02-15

申办/合作机构

Defence Institute of Physiology and Allied Sciences

[+1]

100 项与 Defence Institute of Physiology and Allied Sciences 相关的临床结果

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0 项与 Defence Institute of Physiology and Allied Sciences 相关的专利（医药）

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1,137

项与 Defence Institute of Physiology and Allied Sciences 相关的文献（医药）

2025-06-01·Advances in Redox Research

Recent updates on sickness during acute high-altitude hypoxic exposure and its management

作者: Ahmad, Yasmin ; Mohanty, Swaraj

Chronic and intermittent hypoxia are the two different modalities of developing high-altitude(HA) sickness when an individual is exposed to varying environmental conditions.Exposure to this unusual environment has a great impact on cellular pathophysiol. and mol. signaling.The severity of the physiol. condition relays on the time and duration of stay at a particular altitude and the workload on an individual.The cellular homeostasis shows a variable trend in different tissues and at the systematic level which needs an in-depth understanding of the possible pharmacol. and nonpharmacol. management that will be helpful to overcome stressful conditions.In this review article, we have summarized the altered signaling and mol. pathways during chronic and intermittent hypoxia from reported in vitro and in vivo studies on high-altitude exposure and available management strategies.

2025-06-01·Life Sciences

Decoding Proteomic cross-talk between hypobaric and normobaric hypoxia: Integrative analysis of oxidative stress, cytoskeleton remodeling, and inflammatory pathways

Article

作者: Mohanty, Swaraj ; Ahmad, Yasmin ; Sharma, Poornima

AIMSTo investigate the differential regulation of proteomic landscapes elicited by hypobaric hypoxia (HH) and normobaric hypoxia (NH) and to shed light on the molecular cross-talk underlying pre-acclimatization strategies.MATERIALS AND METHODSLabel-free LCMS-MS quantitative proteomics was employed to evaluate the lung tissues of SD rats (n = 6) subjected to 6 h of acute HH at 25,000 ft associated with reduced barometric pressure, 282 mmHg, and NH at 8 % FiO2.KEY FINDINGSOur findings indicate that NH facilitated the minimal downregulation of proteins involved in maintaining pulmonary cytoskeleton integrity, including calpain 2, vitronectin, and beta-arrestin 1, whereas HH leads to severe downregulation of these proteins, causing a greater cytoskeleton disruption. Proteins contributing to redox homeostasis such as iNOS and SOD, were upregulated in both hypoxic conditions. However, SIRT1-mediated ROS-triggered proteins, including FOXO1 and FOXO4, exhibited upregulation in HH and downregulation in NH. Other proteins, HIF-1α and IDH, were upregulated in HH compared to NH. Additionally, Hemopexin was severely downregulated in HH relative to NH.SIGNIFICANCEFor the first time, this study uncovers the comparative proteomic analysis of two distinct pre-acclimatization interventions by employing varied hypoxia modeling strategies highlighting the key molecular mechanism involved in HH acclimatization induced by differential hypoxia simulating technique.

2025-04-01·Life Sciences

Corrigendum to “Decoding proteomic cross-talk between hypobaric and normobaric hypoxia: Integrative analysis of oxidative stress, cytoskeleton remodeling, and inflammatory pathways” [Life Sci. 371 (2025) 123611]

作者: Mohanty, Swaraj ; Sharma, Poornima ; Ahmad, Yasmin

100 项与 Defence Institute of Physiology and Allied Sciences 相关的药物交易

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100 项与 Defence Institute of Physiology and Allied Sciences 相关的转化医学

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