Delving into the Latest Updates on 沈阳药大雷允上药业有限责任公司 with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与沈阳药大雷允上药业有限责任公司相关的药物

ABRJ

靶点-

作用机制-

在研机构

深圳海王医药科技研究院有限公司 [+1]

原研机构

深圳海王医药科技研究院有限公司

在研适应症

转移性去势抵抗性前列腺癌

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

1

项与沈阳药大雷允上药业有限责任公司相关的临床试验

CTR20231818 / Completed临床1期

ABRJ在中国健康男性受试者中的食物影响研究

评价健康受试者在空腹、进食高脂餐后单次口服ABRJ药代动力学特征以及食物对ABRJ药代动力学的影响。

开始日期2023-07-08

申办/合作机构

沈阳药大雷允上药业有限责任公司

[+1]

100 项与沈阳药大雷允上药业有限责任公司相关的临床结果

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0 项与沈阳药大雷允上药业有限责任公司相关的专利（医药）

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5

项与沈阳药大雷允上药业有限责任公司相关的文献（医药）

Shenyang Yaoke Daxue Xuebao

Application of central composite design-response surface methodology to formulation of flurbiprofen-loaded nanostructured lipid carriers

作者: Yin, Ran ; Han, Fei ; Zhan, Xiaoliang ; Ren, Ping ; Li, Sanming ; Nan, Ning

An optimized formulation of flurbiprofen-loaded nanostructured lipid carriers was obtained by using central composite design-response surface methodol.The effects of formulation variables (amount of flurbiprofen, amount of lecithin, amount of Poloxamer 188 and Tween-80, amount of sodium deoxycholate) on a number of response variables were systemically investigated.The response variables were particle size, zeta potential, entrapment efficiency and drug loaded.A desirability function that combined these four response variables was constructed.A second-order polynomial equation was fitted to the data, and the resulting equation was used to predict the responses in the optimal region.All the investigated response variables were found to be highly dependent on the formulation variables.It was found that the optimum overall desirability of the flurbiprofen-loaded nanostructured lipid carriers could be obtained at 0.222 g of flurbiprofen, 0.300 g of lecithin, 2.000 g of poloxamer 188 and Tween-80, and at 0.100 g of sodium deoxycholate.The exptl. values of the response variables highly agreed with the predict values.Central composite design-response surface methodol. was successfully used to optimize the preparation of flurbiprofen-loaded nanostructured lipid carriers.Overall desirability could be used to represent the most desirable variables in exptl. design.

Gels

The Development of a Polysaccharide-Based Hydrogel Encapsulating Tobramycin-Loaded Gelatine Microspheres as an Antibacterial System

Article

作者: Zhang, Yi-Xuan ; Shi, Mingsheng ; Xu, Yongmeng ; Li, Shuai ; Gu, Junyao ; Wang, Lifeng

Bacterial infection contributes to the bioburden of wounds, which is an essential factor in determining whether a wound can heal. Wound dressings with antibacterial properties that can promote wound-healing are highly desired for the treatment of chronic wound infections. Herein, we fabricated a simple polysaccharide-based hydrogel dressing encapsulating tobramycin-loaded gelatine microspheres with good antibacterial activity and biocompatibility. We first synthesised long-chain quaternary ammonium salts (QAS) by the reaction of tertiary amines with epichlorohydrin. The amino groups of carboxymethyl chitosan were then conjugated with QAS through the ring-opening reaction and QAS-modified chitosan (CMCS) was obtained. The antibacterial analysis showed that both QAS and CMCS could kill E. coli and S. aureus at relatively low concentrations. QAS with 16 carbon atoms has a MIC of 16 μg/mL for E. coli and 2 μg/mL for S. aureus. A series of formulations of tobramycin-loaded gelatine microspheres (TOB-G) were generated and the best formulation was selected by comparing the characters of the microspheres. The microsphere fabricated by 0.1 mL GTA was selected as the optimal candidate. We then used CMCS, TOB-G, and sodium alginate (SA) to prepare physically crosslinking hydrogels using CaCl2 and investigated the mechanical properties, antibacterial activity, and biocompatibility of the hydrogels. In summary, the hydrogel dressing we produced can be used as an ideal alternative for the management of bacteria-infected wounds.

Shenyang Yaoke Daxue Xuebao

Determination of hazardous elements in Brucea Fructus by ICP-MS

作者: Zhang, Hairu ; Xue, Xiusheng ; Li, Wei ; Luo, Yan ; Xu, Yongmeng

An ICP-MS method for the determination of hazardous elements, including Cu, As, Cd, Hg, Pb in Brucea Fructus was established.The samples were digested at high pressure.The five hazardous elements were directly analyzed by ICP-MS.In order to correct the anal. signal drift, ⁷²Ge, ¹¹⁵In and ²⁰⁹Bi which were selected as internal standard elements were added to both the standard solution and sample.For all of the analyzed hazardous elements, the correlative coefficient of the calibration curves was over 0.999 5.The recovery rates of the procedure were 93.2%-107.1%, and its RSD was lower than 9.7%.This method is convenient, quick-acquired and accurate.The method can be used for the quality control of Brucea Fructus and the content determination of trace elements in Brucea Fructus from different habitats.

100 项与沈阳药大雷允上药业有限责任公司相关的药物交易

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100 项与沈阳药大雷允上药业有限责任公司相关的转化医学

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