排名前五的药物类型 | 数量 |
---|---|
中药 | 4 |
小分子化药 | 3 |
排名前五的靶点 | 数量 |
---|---|
SCNA x VDCCs | 1 |
Hemoglobins(血红蛋白) | 1 |
PBPs(细菌青霉素结合蛋白家族) | 1 |
靶点- |
作用机制- |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2023-11-17 |
靶点- |
作用机制- |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2020-08-24 |
作用机制 血红蛋白调节剂 |
在研机构 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区- |
首次获批日期2011-01-01 |
开始日期2024-03-02 |
申办/合作机构 |
开始日期2023-10-08 |
申办/合作机构 |
开始日期2023-07-05 |
申办/合作机构 |
A preferable approach of a combination of a multiwavelength fusion HPLC fingerprint and chemometrics for the quality control of Xiaoer Chiqiao Qingre granules (XCQG) was established in this study. A single-wavelength HPLC fingerprint was performed to identify 18 peaks as common peaks in the beginning, and 12 of them were recognized by HPLC-Q/TOF-MS. To overcome the limitation of the single-wavelength HPLC fingerprint, a three-wavelength (230 nm, 250 nm, and 330 nm) fusion fingerprint was established for a more thorough quality assessment. Six main active ingredients (geniposide, paeoniflorin, forsythin, forsythoside A, baicalin, and wogonoside) were selected as chemical markers for simultaneous quantitative analysis, while the results indicated that the content of other five ingredients except forsythoside A presented comparatively stable. Chemometrics including hierarchical cluster analysis (HCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were performed to evaluate the homogeneity and heterogeneity of sixteen batches of XCQG. The results of the multiwavelength fingerprint were clearly classified into two clusters by HCA, whereas the single-wavelength fingerprint showed no distinct difference between them. OPLS-DA was further employed to prove that the above six main active ingredients made great contributions to clustering. In summary, this integrated analysis provided a better promoted and more comprehensive method to control the quality of XCQG.
药物(靶点) | 适应症 | 全球最高研发状态 |
---|---|---|
小儿豉翘清热糖浆 | 普通感冒 更多 | 批准上市 |
丙胺卡因 ( SCNA x VDCCs ) | 妊娠剧吐 更多 | 批准上市 |
亚甲蓝 ( Hemoglobins ) | 中毒 更多 | 批准上市 |
小儿豉翘清热颗粒(无蔗糖) | 普通感冒 更多 | 批准上市 |
小儿豉翘清热 | 流感病毒感染 更多 | 批准上市 |