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概览

疾病领域	数量

免疫系统疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

AR x HDACs x KLK3	1

关联

1

项与 VIT University 相关的药物

Diindolylmethane

靶点

AR x HDACs x KLK3

作用机制

AR拮抗剂 [+2]

在研机构

VIT University [+2]

原研机构

National Cancer Institute

在研适应症

宫颈癌 [+2]

非在研适应症

前列腺腺癌 [+2]

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期-

100 项与 VIT University 相关的临床结果

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0 项与 VIT University 相关的专利（医药）

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34,866

项与 VIT University 相关的文献（医药）

2025-02-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Nanomolar Hg2+ detection via phenothiazine fluorogenic chemosensor: Applications in water analysis and intracellular imaging

Article

作者: Ilakiyalakshmi, Mohan ; Mohana Roopan, Selvaraj ; Mohandoss, Sonaimuthu ; Arumugam Napoleon, Ayyakannu

A Knoevenagel condensation reaction paved the way for the development of the PTZ-BCN probe namely (z)-2-(1H-benzo[d]imidazole-2-yl)-3-(10-ethyl-10H-phenothiazin-3-yl) acrylonitrile. PTZ-BCN's spectral characteristics were verified through the application of IR, ¹H NMR, ¹³C NMR, and HRMS techniques. The PTZ-BCN probe showed a high selectivity and sensitivity toward Hg²⁺ ions over other interfering competing metal ions in CH₃CN: HEPES buffer (9:1, v/v) system. The addition of Hg²⁺ results in a notable redshift and fluorescence quenching of the PTZ-BCN probe. An examination of the interaction between the PTZ-BCN probe and Hg²⁺ involved recoding ¹H NMR titration spectra, HRMS, DFT analysis, and Job's plot respectively. Quantification of the lowest detectable Hg²⁺ concentration at 2.3 nM, exhibiting a correlation coefficient of R² = 0.9985. PTZ-BCN probe has proven effective in quantitatively determining the existence of Hg²⁺ in real-time water samples, test strips, solid state, and Hela living cells.

2025-01-01·Current Nutrition & Food Science

A Comprehensive Review of Food Recommendation Systems in the Context of Nutritional Therapy for Diabetes Mellitus

作者: Kakani, Vijay ; Chagalasetty, Sreelasya ; Prabakaran, N. ; Rajan, Nitya

Abstract::Food recommendation systems (FRS) have gained prominence for providing personalized dietary recommendations. This paper explores the integration of FRS and nutritional therapy to enhance the management of diabetes mellitus. Nutritional therapy plays a crucial role in controlling blood glucose levels and reducing complications in diabetes. The study reviews and analyzes various food recommendation models in diverse scenarios of diabetic nutritional therapy. By considering specific needs and constraints, the strengths of each model are assessed, leading to the identification of the most suitable model for each scenario. The findings contribute to improving the quality of dietary guidance for individuals with diabetes.

2025-01-01·Journal of Ethnopharmacology

Deciphering the ameliorative effect of Aloe vera (L.) burm. F. extract on histopathological alterations in Streptozotocin-induced WNIN/GR-ob rats

Article

作者: Sunitha, M M ; Deora, Neha ; Venkateshan, Vijayalakshmi ; Harishankar, N. ; Sunitha, M.M. ; Satyavani, M ; Harishankar, N ; Venkataraman, Krishnan ; Satyavani, M.

ETHNOPHARMACOLOGICAL RELEVANCENatural products have emerged as a novel source in the management of non-communicable diseases, more so in diabetes mellitus and its comorbidities. Aloe vera is widely recognized for its anti-hyperglycemic and anti-hyperlipidemic properties and numerous researchers have identified component (s) from Aloe vera attributing to these therapeutic effects.AIM OF THE STUDYThe current work was undertaken to gain insight into the protective effect of Aloe vera (L.) Burm. f. extract to study the cytoarchitecture/histopathological alterations in the target organs in mutant Obese WNIN/GR-Ob rats that were made frank diabetic with streptozotocin.MATERIALS AND METHODSRats were divided into five groups. 1)WNIN-GR-Ob/control group 2)WNIN-GR-Ob treated with STZ 3)WNIN-GR-Ob + STZ + Sitagliptin 4)WNIN-GR-Ob + STZ + Aloe vera 5)WNIN-GR-Ob/control group + Aloe vera. Histopathological analysis of the pancreas, kidney, liver, and adipocytes was done after 4 weeks of treatment.RESULTSThe histopathological examination of STZ-induced diabetic rats revealed significant changes in all the vital organs including cell infiltration, degeneration, and necrosis. Treatment with A. vera negated most of the histopathological changes seen in STZ induced rats. Sitagliptin-which served as a positive control in the present study-reversed the alterations seen in streptozotocin rats.CONCLUSIONConsidering the hypoglycaemic and hypolipidemic activities of Aloe vera that have been previously demonstrated by us, the present study further re-instates the therapeutic efficacy of Aloe vera towards vital organs. It was able to restore islet cells and reduce β-cell damage. In addition, it was also able to aid in kidney tubular regeneration and reverse the degenerative changes brought on by streptozotocin on liver. Further, Aloe vera treated group exhibited moderate hyperplasia with decreased size of adipocytes and reduced macrophage infiltration. Thus, our findings advocate its application as an important nutraceutical in the therapeutic management of diabetes mellitus and associated complications.

100 项与 VIT University 相关的药物交易

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100 项与 VIT University 相关的转化医学

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