A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)

This is a single center study of patients with inactive or mild SLE being performed to determine the safety, tolerability, and pharmacodynamics of DIM.

开始日期2016-01-01

申办/合作机构

Northwell Health, Inc.

NCT01612910

/ Withdrawn临床2期IIT

A Pilot Study of BR-DIM in Women With Stage II-III, Triple Negative, and Androgen Receptor Positive, Invasive Breast Cancer, Who Have Residual Disease Following Surgical Resection After Neoadjuvant Chemotherapy

This study is being done to find out whether a nutritional supplement, called BioResponse-DIM (BR-DIM [oral microencapsulated diindolylmethane]), improves the survival for women who have residual cancer cells following surgery after chemotherapy for breast cancer. BR-DIM is an active ingredient in cruciferous vegetables (broccoli, brussels sprouts and cauliflower). Consumption of these vegetables has been associated with a decreased risk in several cancers. Researchers also hope to find out whether different biomarkers (also called "markers") in the blood predict the chance of breast cancer returning. BR-DIM is thought to be effective in treating stage II-III breast cancer that is triple negative, AR positive (+), and where there is residual cancer cells in the breast after chemotherapy.

开始日期2012-06-01

申办/合作机构

Barbara Ann Karmanos Cancer Institute

[+1]

NCT01391689

/ CompletedN/AIIT

Evaluation of Diindolylmethane Supplementation to Modulate Tamoxifen Efficacy in Breast Cancer The Diindolylmethane Efficacy Study

This phase II/III trial studies how well diindolylmethane (DIM) works and compares it to placebo in treating patients with breast cancer. DIM may slow the growth of tumor cells and be an effective treatment for breast cancer.

开始日期2011-02-01

申办/合作机构

University of Arizona

[+1]

100 项与 Diindolylmethane 相关的临床结果

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100 项与 Diindolylmethane 相关的转化医学

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100 项与 Diindolylmethane 相关的专利（医药）

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1,047

项与 Diindolylmethane 相关的文献（医药）

2025-05-01·JOURNAL OF APPLIED ELECTROCHEMISTRY

An effective alliance for successful coupling: electrochemical alcohol oxidation mediated conversion of indoles to bis(indolyl)methanes

作者: Baravkar, Mayur D. ; Prasad, Bhagavatula L. V.

Electro-organic transformation of indoles to bis(indolyl)methanes (BIMs) has been successfully achieved by combining the electrochem. alc. oxidation reaction (AOR) with indole coupling.The fact that it is the readily available alcs. and not the traditionally used aldehydes or ketones that provide the bridging -CH2- (methylene) for this transformation makes this path extremely attractive and valuable.The formation of aldehydes as reactive intermediates during the AOR has been dexterously utilized to achieve this transformation.Most gratifyingly, the transformation also can be carried out in water-alc. mixtures and the yields and conversions are better than the most of the previously reported chem. catalytic transformations using specially designed metal complexes.Various substituted indoles were selectively converted to their corresponding BIMs in decent yields.This strategy could further be exploited for the synthesis of different natural products, including the much sought after deuterium substituted ones (as CD3OD is readily accessible), and other important biol. active alkaloids and drug mols., etc.

2025-04-18·Environment & Health

Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens

Article

作者: Chen, Lianguo ; Hu, Chenyan ; Sun, Baili

Environmental estrogens (EEs) can induce vitellogenin (VTG) in fish skin mucosa. However, the applicability of mucus VTG in aquatic xenoestrogen monitoring warrants comprehensive exploration. Here, we employed different estrogen exposure scenarios to compare the applicability of mucus VTG and other conventional biomarkers in zebrafish for EE monitoring. After acute exposure to 17α-ethynylestradiol (EE2) at various concentrations, mucus VTG demonstrated higher sensitivity in male zebrafish than in female zebrafish. Mucus VTG change patterns were similar to liver and blood VTG change patterns in males. Time-course exposure experiments revealed that male mucus VTG responded to EE2 much earlier than male liver and blood VTG, underlining the promise of mucus VTG as an early warning signal of aquatic estrogenicity. Exposure to multiple EEs further validated the high sensitivity of male mucus VTG. Proteomics analysis revealed that EE2 exposure potently shifted the proteome structure of male mucosa, and the VTG1 isoform was noted to be the most suitable biomarker. Overall, our results refine the roles of mucus VTG1 from male fish as a noninvasive, rapid, and sensitive biomarker of aquatic xenoestrogens, applicable to ecological risk assessment for animal welfare and ecosystem protection. Future ecological studies may only need to sample male fish mucus without sacrificing females.

2025-03-01·Neurotherapeutics

3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury

Article

作者: Aliancin, Isabelle ; Zeligs, Michael A ; de Rivero Vaccari, Juan Pablo ; Benton, Hannah ; Rahimzadeh, Tyler S ; Chlipala, Elizabeth A ; Mastromatteo-Alberga, Patrizzia ; Gorthy, Aditi S ; Balleste, Alyssa F ; Dallera, Carlos A ; Placeres-Uray, Fabiola ; Atkins, Coleen M ; Dietrich, W Dalton ; Dominguez-Torres, Maria ; Jacobs, Irwin C

3,3'-Diindolylmethane (DIM), a naturally occurring bis-indole found in cruciferous vegetables and produced in small amounts in the normal flora of the human gut, has demonstrated neuroprotective benefits in models of CNS hypoxia and stroke. In the CNS, DIM modulates the activation of the aryl hydrocarbon receptor (AhR) and inhibits its pro-inflammatory effects. Although capable of crossing the blood brain barrier, DIM's bioavailability is limited by its low solubility. Dispersed BR4044 provides a nanoscale high-solubility DIM suspension with the potential for treating traumatic brain injury (TBI). The present study aimed to determine whether BR4044 treatment could reduce pathology and improve behavioral recovery following moderate TBI. Male Sprague Dawley rats received moderate fluid percussion injury or sham surgery followed by vehicle or BR4044 treatment in the acute recovery period. TBI BR4044 animals showed significantly reduced cortical and hippocampal edema and lower levels of serum-derived extracellular vesicles compared to TBI Vehicle animals. BR4044 treatment of TBI animals preserved sensorimotor function and associative fear memory. Cortical contusion size and neuronal loss in the parietal cortex and CA3 region of the hippocampus were also significantly reduced with BR4044 treatment. BR4044 also decreased microbleeding and nuclear AhR at the contusion site. This translational study demonstrates that BR4044 ameliorates pathology and improves neurological outcomes following TBI by reducing brain edema, lowering acute extracellular vesicle release, modulating AhR, preserving cortical and hippocampal neurons, reducing red blood cell (RBC) extravasation into the injured brain, and promoting behavioral recovery.

项与 Diindolylmethane 相关的新闻（医药）

2023-12-01

·PRNewswire

Maggie Q's ActivatedYou, Introduces the Latest Addition to Their Best-Selling Supplement, Morning Complete Mixed Berry Flavor

A Potent Daily Wellness Beverage Crafted to Enhance Digestive Function, Boost Energy Levels, and Promote Overall Well-Being LOS ANGELES, Dec. 1, 2023 /PRNewswire/ -- ActivatedYou® introduces a new flavor of their best-selling supplement: Morning Complete Mixed Berry. ActivatedYou Morning Complete is a daily wellness drink formulated with a thoughtfully selected blend of nutrients to help users begin each day with a healthy start and achieve their best state of well-being. This carefully crafted nutrient blend consists of 8 unique wellness-support blends designed to enhance your body's performance and help it function at its peak.†* Continue Reading ActivatedYou Morning Complete is a daily dietary supplement beverage that embodies "wellness in a glass." In addition to the new Mixed Berry flavor, Morning Complete comes in two other delicious flavors: Apple Cinnamon and Citrus Medley. What is ActivatedYou Morning Complete? ActivatedYou Morning Complete is a daily dietary supplement beverage that embodies "wellness in a glass." In addition to the new Mixed Berry flavor, Morning Complete comes in two other delicious flavors: Apple Cinnamon and Citrus Medley. This comprehensive formula combines metabolic support, probiotics, prebiotics, antioxidants, fiber-rich prebiotics, green superfoods, adaptogens, and liver support blends. By harnessing the power of nutrient-rich green vegetables, Morning Complete delivers essential fiber, probiotics, prebiotics, and health-supporting antioxidants. It actively nurtures gut health, fostering the growth of beneficial bacteria for a flourishing microbiome. With carefully selected ingredients that bolster holistic well-being, this blend supports liver and cellular function, supports your body's defenses against oxidative stress, and helps promote mental clarity.†* ActivatedYou Morning Complete Wellness Blend Ingredients Metabolic Enhancing Blend: Helps boost metabolism through the power of green tea leaves, ginger root, white tea leaves, turmeric root, bitter melon fruit, and black pepper fruit.†* Probiotic Blend: Supports a robust and diverse digestive environment by incorporating a spectrum of nine probiotic strains, including B. coagulans, L. gasseri, L. plantarum, L. rhamnosus, B. bifidum, B. longum, L. acidophilus, L. casei, and S. thermophilus.† Sugar Level Support: Supports healthy blood sugar levels already within normal range using a blend of Gymnema sylvestre leaves, fennel seeds, and pine bark extract.†* Green Superfoods Blend: Revitalize your body with spinach, broccoli, kale, mulberry leaf extracts, alfalfa leaves, and barley grass, providing essential nutrients and renewed energy.†* Antioxidant Blend: Assists your body in defending against environmental pollutants and oxidative stress by harnessing the polyphenol-rich lycium berries, pomegranate fruit extracts, and Polygonum cuspidatum root extracts (containing 50% resveratrol).†* Prebiotic and Fiber Blend: Nourishes your microbiome with vital support for beneficial gut bacteria, featuring a combination of chicory root fructooligosaccharides and cinnamon bark.†* Adaptogens: Supports your body's stress management with the use of adaptogens such as astragalus root extracts, Rhodiola rosea root extracts, and DIM (diindolylmethane).†* Liver Support Blend: Supports mitochondrial functions with organic aloe vera leaves and milk thistle seed extract, renowned for their positive impact on liver well-being.†* How to Use ActivatedYou Morning Complete To add ActivatedYou Morning Complete into your daily regimen, simply add one scoop of the easy-dissolve powder to the beverage of your choice. Maggie Q's ActivatedYou suggests mixing Morning Complete with 8oz of water or iced green tea. ActivatedYou Morning Complete can be purchased from the official ActivatedYou website. It is available for $79 and comes with a 90-day money-back guarantee (minus shipping), ensuring your satisfaction. About Maggie Q As a health advocate, animal rights activist, founder of fitness apparel brand Qeep Up, ActivatedYou founder, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

2023-09-12

·PRNewswire

Maggie Q's ActivatedYou® Morning Complete® Celebrates 3000+ Positive Reviews

ActivatedYou Morning Complete Supports Overall Well-Being With Eight Unique Wellness Blends LOS ANGELES, Sept. 12, 2023 /PRNewswire/ -- Morning Complete® by Maggie Q's ActivatedYou ® has now received over 3000 positive reviews across various platforms. This groundbreaking supplement was meticulously designed to support your holistic well-being. ActivatedYou Morning Complete combines the synergistic power of prebiotics, probiotics, and six carefully curated nutrient blends to support your metabolism, help facilitate weight management, and enhance your vitality.†* What is ActivatedYou Morning Complete?†* Continue Reading With two delicious flavors, Apple Cinnamon and the newer Citrus Medley, ActivatedYou Morning Complete daily drink is specially crafted to support overall well-being. Its comprehensive formula encompasses a range of powerful blends, including metabolic enhancement, prebiotic and high fiber, probiotic, antioxidant, green superfoods, adaptogens, liver support, and sugar-balancing support. ActivatedYou Morning Complete is a daily dietary supplement wellness beverage that encapsulates the essence of "wellness in a glass." Tailored to elevate overall well-being, this beverage is available in two tasty flavors: Apple Cinnamon and the newer Citrus Medley. Its comprehensive formulation blends metabolic reinforcement, probiotics, prebiotics, antioxidants, fiber-containing prebiotics, green superfoods, adaptogens, and liver support. Harnessing the power of nutrient-dense green vegetables, Morning Complete provides users with vital fiber, probiotics, prebiotics, and health-supportive antioxidants. It proactively nurtures gut health, cultivating advantageous bacteria for a flourishing microbiome. Through hand-selected ingredients that fortify holistic well-being, this formula supports liver and cellular function, your body's defenses to oxidative stress, a positive mood, and mental clarity. Ingredients in ActivatedYou Morning Complete†* Probiotic Blend: Fosters a thriving, digestive ecosystem with an array of 9 probiotic strains: B. coagulans, L. gasseri, L. plantarum, L. rhamnosus, B. bifidum, B. longum, L. acidophilus, L. casei, and S. thermophilus. Prebiotic and Fiber Blend: Enriches your microbiome with essential sustenance for beneficial gut bacteria, this blend includes chicory root fructooligosaccharides and cinnamon bark.† Green Superfoods Blend: Energizes your body with spinach, broccoli, kale, mulberry leaf extracts, alfalfa leaves, and barley grass, delivering vital nutrients and vitality.† Metabolic Enhancing Blend: Boosts metabolism with green tea leaves, ginger roots, white tea leaves, turmeric roots, bitter melon fruit, and black pepper fruit.† Antioxidant Blend: Helps your body combat environmental pollutants and oxidative stress with polyphenol-rich Lycium berries, pomegranate fruit extracts, and Polygonum cuspidatum root extracts (50% resveratrol).† Adaptogens: Aids your body's stress response by employing adaptogens like astragalus root extracts, Rhodiola rosea root extracts, and DIM (diindolylmethane).† Liver Support: Supports mitochondrial and detoxification functions with organic aloe vera leaves and milk thistle seed extracts, renowned for their positive impact on liver well-being.† Sugar Level Support: Supports healthy blood sugar levels already within normal range with this optimized performance blend of Gymnema sylvestre leaves, fennel seeds, and pine bark extracts.† How to incorporate ActivatedYou Morning Complete into your routine: To seamlessly integrate ActivatedYou Morning Complete into your daily regimen, simply add one scoop of the easy-dissolve powder to the beverage of your choice. Maggie Q's ActivatedYou suggests mixing Morning Complete with 8oz of water or iced green tea. Where to purchase ActivatedYou Morning Complete: You can conveniently buy ActivatedYou Morning Complete from the official ActivatedYou website. It is available for $79 and comes with a 90-day money-back guarantee (minus shipping), ensuring your satisfaction. Choose between two delightful flavors: apple cinnamon and the invigorating new citrus medley option. About Maggie Q As a health advocate, animal rights activist, the founder of fitness apparel brand Qeep Up, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou™ ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

2023-08-02

·PRNewswire

LEADING WOMEN'S HEALTH BRAND O POSITIV LAUNCHES OVARIAN SUPPORT VITAMIN CAPSULES

Supplements Support Ovarian and Reproductive Health and Aid in Regulating Menstrual Cycles LOS ANGELES, Aug. 2, 2023 /PRNewswire/ -- Today, O Positiv, the women's health brand behind FLO, the first-ever PMS support supplement on the market, introduces their newest product FLO Ovarian Support Vitamin Capsules. Continue Reading FLO Ovarian Support O Positiv's mission is to prioritize and advocate for women with effective products to address health concerns that have been historically overlooked. Since launching the FLO PMS Gummy in December 2018, O Positiv has positioned themselves as a premiere wellness brand with a range of products to address vaginal, digestive, skin, menstrual and menopausal health. Now, the brand is expanding from wellness supplements to a broader all-encompassing women's health company. O Positiv's co-founder, Brianna Bitton, was recently diagnosed with PCOS. Her struggle with painful and irregular periods continues to be a catalyst for the brand to launch much needed and effective products for women. More than 5 million women in the United States need help with Ovarian issues, especially women of reproductive age. For women suffering from hormonal imbalances, irregular periods and excess androgen levels, FLO Ovarian Support is designed to help using plant- based ingredients backed by science. "We made this product for the millions of women who know they need support for ovarian function," says co-founder Bobby Bitton, "And, so that millions more can begin the conversation with their doctors about the symptoms they're facing and how better ovarian support can help." Each FLO Ovarian Support Vitamin Capsule is formulated with the scientifically backed 40:1 ratio of Myo-Inositol and D-Chiro-Inositol to help support ovarian health and cycle regularity, folate to support reproductive health, and diindolylmethane (commonly known as DIM) to support healthy hormone levels. "Outside of cyclical PMS symptoms, hormone imbalances can cause irregular cycles and overactive hair growth. FLO Ovarian Support's ingredients help support healthy hormone levels," says Dr. Jessica Shepherd, OBGYN. "FLO Ovarian Support is great for patients who struggle with irregular cycles or overactive oil production on their face or scalp." O Positiv plans to continue expanding their range of products, which currently includes favorites - FLO PMS Gummies & Capsules, GOGO Prebiotic Fiber Gummies, URO Urinary Tract & URO Vaginal Probiotic Capsules, GOGO Bloating and Gas Capsules, MENO Menopause Gummies & Capsules and RETRO Glowing Skin Gummies & Capsules, among others. To further advocate for women's health, O Positiv works with the global nonprofit Period to end period poverty and stigma through service, education and advocacy. FLO Ovarian Support Vitamin Capsules retail $42.99 for a one-time purchase or subscription for $34.99 opositiv.com. About O Positiv O Positiv is the health and wellness brand prioritizing women by creating effective products to address health concerns that have been historically overlooked. O Positiv aims to break taboos with a line of products to address vaginal, skin, digestive, menstrual and menopausal health. For more information, visit opositiv.com. Follow O Positiv on Instagram at @opositiv Press Contact: Shauna Aminzadeh/Break Point [email protected] SOURCE O Positiv

100 项与 Diindolylmethane 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Diindolylmethane	-	DB11875

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
宫颈上皮内瘤样病变	临床3期	美国	-	2000-09-01
子宫颈发育不良	临床3期	美国	-	2000-09-01
宫颈癌	临床3期	-	National Cancer Institute	-
三阴性乳腺癌	临床2期	-	Barbara Ann Karmanos Cancer Institute	2012-06-01
前列腺腺癌	临床1期	美国	National Cancer Institute	2007-02-01
去势抵抗性前列腺癌	临床1期	美国	Barbara Ann Karmanos Cancer Institute	2005-08-01
银屑病	临床前	印度	VIT University	2024-04-11
转移性前列腺癌	临床前	美国	Wayne State University School of Medicine	2005-05-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AACR2012	N/A	-	-	Cisplatin	糧齋壓襯廠顧衊觸膚艱(衊鏇觸積壓構願構醖齋) = 鬱餘窪壓艱衊構獵壓餘廠壓窪壓構壓鬱蓋網壓 (醖積網蓋遞餘獵鹹糧艱 )	-	2012-04-15
				Gemcitabine	糧齋壓襯廠顧衊觸膚艱(衊鏇觸積壓構願構醖齋) = 繭醖糧範艱遞遞鹽積膚廠壓窪壓構壓鬱蓋網壓 (醖積網蓋遞餘獵鹹糧艱 )
ASTRO2011	N/A	去势抵抗性前列腺癌	-	B-DIM	遞製蓋築築蓋鏇築觸蓋(廠網醖窪衊簾襯鬱繭襯) = 膚醖廠選鏇淵網構繭蓋淵網糧選壓餘顧夢鏇選 (願壓餘淵鬱選襯繭襯製 )	-	2011-10-01
				B-DIM (Radiation)	遞製蓋築築蓋鏇築觸蓋(廠網醖窪衊簾襯鬱繭襯) = 壓膚壓積窪鹽憲鹹鹹窪淵網糧選壓餘顧夢鏇選 (願壓餘淵鬱選襯繭襯製 )
NCT00212381 (Pubmed \| Gynecol Oncol)	临床3期	子宫颈发育不良	64	Oral diindolylmethane (DIM)	網範顧淵鏇願窪糧夢築(鏇鹽範餘餘製齋網鏇蓋) = 淵鏇艱廠糧鑰膚製餘構觸鹹顧鹽構醖鬱窪艱築 (憲壓餘廠衊鬱製廠壓餘 )	-	2010-03-01