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2

项与 Saurashtra University 相关的药物

IN466257

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Saurashtra University

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Saurashtra University

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发育不良 [+1]

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IN202321063161

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Saurashtra University

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Saurashtra University

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乳腺癌

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100 项与 Saurashtra University 相关的临床结果

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0 项与 Saurashtra University 相关的专利（医药）

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4,181

项与 Saurashtra University 相关的文献（医药）

2025-12-31·Essential Chem

Development and validation of stability indicating RP-HPLC and HPTLC methods for determination of xanthinol nicotinate in its tablet dosage forms

作者: Shilu, Ankita ; Bagada, Hina

2025-08-01·Materials Science and Engineering: B

Influence of substrates and buffer layers on the magnetic properties of DyMnO3 thin film heterostructures

作者: Rathod, Urjitsinh ; Katba, Savan ; Jethva, Sadaf ; Hajra, Sumana ; Yadav, Sajan ; Ravalia, Ashish ; Choudhary, R. J.

Thin film heterostructures play a pivotal role in advancing various electronic and magnetic device applications due to their unique properties and tunability.In this study, we investigate three distinct DyMnO₃ based thin film heterostructures: DyMnO₃/Sr_0.998Nb_0.002TiO₃ (100), DyMnO₃/LaNiO₃/LaAlO₃ (100) and DyMnO₃/La_0.7Sr_0.3MnO₃/SrTiO₃ (100) fabricated using the pulsed laser deposition technique (PLD).The study of structural, morphol., and magnetic properties is carried out on heterostructures using X-ray diffraction (XRD), Atomic Force Microscopy (AFM), and magnetic susceptibility measurements.It indicates the crystalline structure along with the epitaxial growth of films as obtained from XRD anal.AFM imaging further provides the surface morphol. as well as the roughness.This study elucidates the role of strain and interfacial effects in tuning the magnetic properties of DyMnO₃ heterostructures.The comparison and anal. of these results provide valuable insights into the interplay between structural, morphol. and magnetic properties in thin film heterostructures.M-H loops at 5 K were studied using math. formulas of various combinations of different types of magnetism such as Langevin Paramagnetism, Antiferromagnetism, Non-linear Ferromagnetism and Diamagnetism to formulate the Python scripts, which have been used to understand the magnetic contributions of the different layers in the overall heterostructure and derive the values for the same.This study not only contributes to our fundamental understanding of these materials but also holds promise for the development of novel electronic and magnetic devices with tailored functionalities.

2025-06-01·Journal of Pharmaceutical Sciences

Enhancing the solubility and bioavailability of itraconazole through pharmaceutical cocrystallization: A promising strategy for drug formulation

Article

作者: Borkhataria, Chetan ; Pethani, Trupesh ; Parmar, Ghanshyam ; Raichura, Komal ; Chhatbar, Meet ; Manek, Ravi ; Patel, Om ; Mori, Dhaval

Itraconazole, a potent antifungal agent, is classified as a Biopharmaceutics Classification System (BCS) Class II drug, exhibiting high permeability but poor aqueous solubility, which significantly limits its bioavailability and therapeutic efficacy. Conventional solubility enhancement techniques such as salt formation, particle size reduction, and encapsulation have shown limited success due to the drug's non-ionizable nature and pH-dependent solubility. Cocrystallization has emerged as a promising pharmaceutical strategy to address these limitations by modifying the crystal lattice structure through non-covalent interactions with pharmaceutically acceptable co-formers. This study explores the formulation of Itraconazole cocrystals with various co-formers to enhance its solubility, dissolution rate, and micromeritic properties, thereby improving its processability in solid dosage forms. The optimized cocrystal formulation (B16) demonstrated a 2.4-fold increase in solubility in 0.1 N HCl (60.47 ± 2.7 µg/mL) and a 25.77-fold increase in phosphate buffer (pH 6.8, 60.57 ± 5.64 µg/mL) compared to pure Itraconazole. The dissolution rate was also significantly improved, with 40.12% drug release in 120 minutes in acidic medium, compared to 32.65% for pure Itraconazole. Furthermore, pharmacokinetic studies in rats revealed a 2.8-fold increase in AUC (3717.58 ng·h/mL) and a C_max of 206.86 ng/mL, compared to 88.06 ng/mL for the pure drug. The study further examines the industrial feasibility of cocrystallization as an innovative approach for optimizing poorly soluble drugs in commercial formulations. The results highlight the potential of cocrystal technology in overcoming formulation challenges and advancing the development of more effective and patient-friendly antifungal therapies.

100 项与 Saurashtra University 相关的药物交易

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100 项与 Saurashtra University 相关的转化医学

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