Delving into the Latest Updates on 南方医科大学顺德医院（佛山市顺德区第一人民医院） with Synapse

The impact of continuous non-invasive arterial blood pressure monitoring on outcomes of cesarean section and neonates after spinal-epidural anesthesia

开始日期2024-01-08

申办/合作机构

南方医科大学顺德医院（佛山市顺德区第一人民医院）

100 项与南方医科大学顺德医院（佛山市顺德区第一人民医院）相关的临床结果

登录后查看更多信息

0 项与南方医科大学顺德医院（佛山市顺德区第一人民医院）相关的专利（医药）

登录后查看更多信息

12

项与南方医科大学顺德医院（佛山市顺德区第一人民医院）相关的文献（医药）

2024-10-01·The Spine Journal

Value of different preoperative bone evaluation methods in predicting intraoperative screw insertion torque: a prospective clinical comparative trial

Article

作者: Wang, Zhiyun ; Yuan, Weiquan ; Chen, Tao ; Xie, Faqin ; Yang, Ruobing ; Mao, Raobing ; Wang, Xiaoqian ; Yin, Houjie ; Zheng, Guanghao ; Lin, Wentao

BACKGROUND CONTEXTEstablishing good screw-bone structural stability is conducive to reducing the risk of postoperative screw loosening. Screw insertion torque is an objective index for evaluating screw-bone structural stability. Therefore, accurate prediction of screw insertion torque can improve the preoperative evaluation of patients, optimize the surgical plan, and improve the surgical effect. At present, the correlation between different bone assessment methods and screw insertion torque is unclear.PURPOSEThe aim of this study was to evaluate the correlation between different bone assessment methods and screw insertion torque and to optimize the predictive performance of screw insertion torque through mathematical modeling combined with different radiology methods.DESIGNProspective cross-sectional study.PATIENT SAMPLESSeventy-seven patients with preoperatively available DXA, CT and MRI data who underwent spinal fixation surgeries between October 2022 and September 2023 and 357 sets of screw data were included in this analysis.OUTCOME MEASURESSpinal, vertebrae-specific and screw trajectory's BMD were measured preoperatively by different imaging modalities. Intraoperative screw insertion torque was measured using an electronic torque wrench.METHODSPearson linear correlation, scatter plots and univariate linear regression were used to evaluate the correlation between different bone evaluation methods and screw insertion torque. Different bone evaluation methods were fitted into the prediction model of screw torque and the related equations were obtained.RESULTSScrew insertion torque had the strongest positive correlation with the volumetric bone mineral density (vBMD) of the screw trajectory (Pedicle screw insertion torque (PSIT): R = 0.618, p<.001; Terminal screw insertion torque (TSIT): R = 0.735, p<.001). A weak negative correlation was found between the screw insertion torque and level specific vertebral bone quality (VBQ) (PSIT: R = -0.178, p=.001; TSIT: R = -0.147, p=.006). We also found that the PSIT was strongly correlated with the TSIT (R = 0.812, p<.001).CONCLUSIONSCompared to other bone quality assessment methods, screw trajectory vBMD may be better predict the magnitude of screw insertion torque. In addition, we further optimized preoperative assessments by constructing a mathematical model to better predict screw insertion torque. In conclusion, clinicians should select appropriate preoperative bone quality assessment methods, identify potential low-torque patients, optimize surgical plans, and ultimately improve screw insertion accuracy and reduce postoperative screw loosening rate.

2024-10-01·Pharmacological Research

Omega-3 PUFAs slow organ aging through promoting energy metabolism

Article

作者: Zhang, Haixia ; Zhou, Lili ; Hou, Fan Fan ; Li, Xiaolong ; Ma, Kunling ; Wang, Xiaoxu ; Miao, Jinhua ; Zhou, Shan ; Li, Fanghong ; Shen, Weiwei ; Liu, Youhua ; Zhao, Allan Zijian ; Ling, Xian ; Xing, Chaofeng ; Liu, Jiafeng ; Luo, Pei ; Liang, Ye ; Zhou, Hong ; Xiong, Yabing ; Zhang, Meijia ; Chen, Qiurong

Energy metabolism disorder, mainly exhibiting the inhibition of fatty acid degradation and lipid accumulation, is highly related with aging acceleration. However, the intervention measures are deficient. Here, we reported Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), especially EPA, exerted beneficial effects on maintaining energy metabolism and lipid homeostasis to slow organ aging. As the endogenous agonist of peroxisome proliferator-activated receptor α (PPARα), Omega-3 PUFAs significantly boosted fatty acid β-oxidation and ATP production in multiple aged organs. Consequently, Omega-3 PUFAs effectively inhibited age-related pathological changes, preserved organ function, and retarded aging process. The beneficial effects of Omega-3 PUFAs were also testified in mfat-1 transgenic mice, which spontaneously generate abundant endogenous Omega-3 PUFAs. In conclusion, our study innovatively demonstrated Omega-3 PUFAs administration in diet slow aging through promoting energy metabolism. The supplement of Omega-3 PUFAs or fat-1 transgene provides a promising therapeutic approach to promote healthy aging in the elderly.

2024-09-01·International Immunopharmacology

FKBP38 deletion exacerbates ConA-induced hepatitis by promoting the immune response through the MCP-1/p38 pathway

Article

作者: Xing, Chaofeng ; Tang, Minyi ; Xiao, Gengmiao ; Bi, Xinyun ; Zhao, Allan Z ; Wang, Shuai ; Li, Fanghong ; Liu, Aolu

Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune dysregulation and hepatocyte damage. FKBP38, a member of the immunophilin family, has been implicated in immune regulation and the modulation of intracellular signaling pathways; however, its role in AIH pathogenesis remains poorly understood. In this study, we aimed to investigate the effects of hepatic FKBP38 deletion on AIH using a hepatic FKBP38 knockout (LKO) mouse model created via cre-loxP technology. We compared the survival rates, incidence, and severity of AIH in LKO mice with those in control mice. Our findings revealed that hepatic FKBP38 deletion resulted in an unfavorable prognosis in LKO mice with AIH. Specifically, LKO mice exhibited heightened liver inflammation and extensive hepatocyte damage compared to control mice, with a significant decrease in anti-apoptotic proteins and a marked increase in pro-apoptotic proteins. Additionally, transcriptional and translational levels of pro-inflammatory cytokines and chemokines were significantly increased in LKO mice compared to control mice. Immunoblot analysis showed that MCP-1 expression was significantly elevated in LKO mice. Furthermore, the phosphorylation of p38 was increased in LKO mice with AIH, indicating that FKBP38 deletion promotes liver injury in AIH by upregulating p38 phosphorylation and increasing MCP-1 expression. Immune cell profiling demonstrated elevated populations of T, NK, and B cells, suggesting a dysregulated immune response in LKO mice with AIH. Overall, our findings suggest that FKBP38 disruption exacerbates AIH severity by augmenting the immune response by activating the MCP-1/p38 signaling pathway.

100 项与南方医科大学顺德医院（佛山市顺德区第一人民医院）相关的药物交易

登录后查看更多信息

100 项与南方医科大学顺德医院（佛山市顺德区第一人民医院）相关的转化医学

登录后查看更多信息