Delving into the Latest Updates on Max Planck Institute of Biophysics with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

SARS-CoV-2 PLpro(新冠病毒Plpro蛋白)	1

关联

1

项与 Max Planck Institute of Biophysics 相关的药物

GRL-0617

靶点

SARS-CoV-2 PLpro

作用机制

SARS-CoV-2 PLpro抑制剂

在研机构

University of Illinois [+2]

原研机构

Johann Wolfgang Goethe-Universität Frankfurt am Main [+1]

在研适应症

新型冠状病毒感染 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Max Planck Institute of Biophysics 相关的临床结果

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0 项与 Max Planck Institute of Biophysics 相关的专利（医药）

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21

项与 Max Planck Institute of Biophysics 相关的文献（医药）

2024-10-01·Cell Death & Differentiation

Feeding cancer to death - a triad of aromatic acids reduces tumor growth

作者: Xavier, Audrey ; Dikic, Ivan

2024-08-01·Journal of Molecular Biology

Molecular Mechanisms and Physiological Functions of Autophagy

Article

作者: Graef, Martin ; Wilfling, Florian

2024-08-01·Journal of Molecular Biology

Selective Autophagy of Macromolecular Complexes: What Does It Take to be Taken?

Review

作者: Wilfling, Florian ; Lizarrondo, Javier

Proteins are known to perform an astonishing array of functions thanks to their ability to cooperate and modulate each other's properties. Inside cells, proteins can assemble into large multi-subunit complexes to carry out complex cellular functions. The correct assembly and maintenance of the functional state of macromolecular protein complexes is crucial for human health. Failure to do so leads to loss of function and potential accumulation of harmful materials, which is associated with a variety of human diseases such as neurodegeneration and cancer. Autophagy engulfs cytosolic material in autophagosomes, and therefore is best suited to eliminate intact macromolecular complexes without disassembling them, which could interfere with de novo assembly. In this review, we discuss the role of autophagy in the selective degradation of macromolecular complexes. We highlight the current state of knowledge for different macromolecular complexes and their selective autophagic degradation. We emphasize the gaps in our understanding of what it takes for these large macromolecular complexes to be degraded and point to future work that may shed light on the regulation of the selective degradation of macromolecular complexes by autophagy.

100 项与 Max Planck Institute of Biophysics 相关的药物交易

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100 项与 Max Planck Institute of Biophysics 相关的转化医学

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