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Effects of Knee Neuromuscular Control Exercise Program using Inelastic Taping on Pain, Function, Quality of Life, Balance and Muscle Thickness and Contraction Rate in Patients with Knee Osteoarthritis

开始日期2024-01-15

申办/合作机构

Daejeon University

KCT0008803 / Not yet recruitingN/AIIT

Effect of a neck orthosis during sling exercise on muscle tension and headache in subjects with forward head posture and tension headaches.

开始日期2023-12-01

申办/合作机构

Daejeon University

KCT0008636 / RecruitingN/AIIT

Effects of eye ball exercise program on chronic neck pain patients with tension headache and forward head posture

开始日期2023-06-26

申办/合作机构

Daejeon University

100 项与 Daejeon University 相关的临床结果

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0 项与 Daejeon University 相关的专利（医药）

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2,596

项与 Daejeon University 相关的文献（医药）

2024-12-31·International Journal of Pavement Engineering

Application of infrared thermal images for sinkhole detection with time-series and time-difference index data through a convolution neural network

作者: Jang, Byeong-su ; Yoon, Hyung-Koo

2024-11-01·General Hospital Psychiatry

Effectiveness of meditation for fatigue management: Insight from a comprehensive systematic review and meta-analysis

Article

作者: Ahn, Yo-Chan ; Park, Byung-Jin ; Choi, Yujin ; Lee, Eun-Jung ; Lee, Jin-Seok ; Son, Chang-Gue

OBJECTIVEThis systematic review and meta-analysis revealed the effectiveness of meditation in addressing fatigue, given its widespread use as a remedy for sleep disturbances and fatigue.METHODWe analyzed 29 randomized controlled trials from MEDLINE and the Cochrane Library, spanning from December 31, 2022. We conducted two metaanalyses using mean difference (MD) with normalized data and standardized mean difference (SMD) with original data.RESULTSThese trials included various populations, with baseline fatigue severity observed at 52.2 ± 16.0 points among 4104 participants. After an average meditation duration of 9.6 ± 4.7 weeks, fatigue scores decreased significantly by 6.4 points of MD [95% CI, 4.3-8.5] compared to controls. The most significant reduction occurred in the sub-healthy group (MD 8.2 [95% CI, 2.7 to 13.8]), followed by the general group (MD 6.9 [95% CI, 0.4 to 13.4]), and the disease group (MD 5.7 [95% CI, 3.4 to 8.0]). Notably, meditation-based anti-fatigue effects were particularly pronounced for mental fatigue (MD 10.0 [95% CI, 4.3 to 15.6]), especially with expert guidance and supplementary homework.CONCLUSIONThese findings align with meta-analysis results using standardized mean difference (SMD), providing evidence for meditation as an effective nonpharmacological intervention for fatigue management, while also informing effective meditation approaches.REGISTRATION NUMBERCRD42023395551 in PROSPERO.

2024-10-01·Molecular Neurobiology

Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid

Article

作者: Kim, Jieun ; Kim, Ki-Joong ; Hwang, Jinyeon ; Namgung, Uk ; Lee, Kang-Woo ; Han, Yunha

Injection of polyinosinic:polycytidylic acid (poly(I:C)) into experimental animals induces neuroimmunological responses and thus has been used for the study of neurological disorders such as anxiety, depression, and chronic fatigue. Here, we investigated the effects of vagus nerve stimulation (VNS) on poly(I:C)-induced neuroinflammation and associated behavioral consequences in rats. The microglia in the prefrontal cortex (PFC) displayed the activated form of morphology in poly(I:C)-injected rats and changed to a normal shape after acute VNS (aVNS). Production of phospho-NF-κB, phospho-IκB, IL-1β, and cleaved caspase 3 was elevated by poly(I:C) and downregulated by aVNS. In contrast, phospho-Akt levels were decreased by poly(I:C) and increased by aVNS. Neuronal production of fractalkine (CX3CL1) in the PFC was markedly reduced by poly(I:C), but recovered by aVNS. Fractalkine interaction with its receptor CX3CR1 was highly elevated by VNS. We further demonstrated that the pharmacological blockade of CX3CR1 activity counteracted the production of IL-1β, phospho-Akt, and cleaved form of caspase 3 that was modulated by VNS, suggesting the anti-inflammatory effects of fractalkine-CX3CR1 signaling as a mediator of neuron-microglia interaction. Behavioral assessments of pain and temperature sensations by von Frey and hot/cold plate tests showed significant improvement by chronic VNS (cVNS) and forced swimming and marble burying tests revealed that the depressive-like behaviors caused by poly(I:C) injection were rescued by cVNS. We also found that the recognition memory which was impaired by poly(I:C) administration was improved by cVNS. This study suggests that VNS may play a role in regulating neuroinflammation and somatosensory and cognitive functions in poly(I:C)-injected animals.

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