The study was conducted on patients with advanced right-sided colon cancer, and the clinical pathological and prognostic data of the patients were compared between the two groups of patients who were randomly divided into those undergoing SMV and SMA left resection, with the aim of resolving the controversy over the left resection boundary of CME/D3 lymph node dissection through this study, and to clarify whether SMA left resection is superior to SMV left resection.

开始日期2024-07-01

申办/合作机构

浙江省肿瘤医院

[+19]

ChiCTR2300068136

/ Suspended临床4期IIT

Effect of intraoperative dexmedetomidine on postoperative ileus of parturient after cesarean section under combined spinal and epidural anesthesia

开始日期2023-02-15

申办/合作机构

瑞安市人民医院

NCT05725590

/ RecruitingN/AIIT

A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy

The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy remains controversial. This study aimed to evaluate the benefits of external and internal stents using the Updated Alternative Fistula Risk Score in both high-risk and low-risk patients with regard to the incidence of clinically relevant postoperative pancreatic fistula.

开始日期2023-02-02

申办/合作机构

浙江大学医学院附属第二医院（浙江省第二医院）

[+4]

100 项与瑞安市人民医院相关的临床结果

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0 项与瑞安市人民医院相关的专利（医药）

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658

项与瑞安市人民医院相关的文献（医药）

2025-12-31·Artificial Cells, Nanomedicine, and Biotechnology

The integration of metabolites from Forsythia suspensa and gut microbiota ameliorates drug-induced liver injury: network pharmacology and molecular docking studies

Article

作者: Wang, Libo ; Wang, Jiabing ; Wang, Yanni ; Qian, Bingjie ; Peng, Xiangxiang

This study integrates metabolites from Forsythia suspensa (FS) and gut microbiota GM to assess combined therapeutic efficacy against drug-induced liver injury (DILI) using network pharmacology and molecular docking. Metabolites of FS and GM were retrieved from the NPASS and gutMGene databases, respectively. Relevant targets for metabolites and DILI-related targets were identified through public databases. The PPI network and KEGG pathway analysis were employed to identify hub targets and key signalling pathways. Furthermore, we performed a molecular docking assay on the active metabolites and targets to verify the network pharmacological concept. The physicochemical properties and toxicity of identified key metabolites were assessed using in silico platforms. 19 final targets were recognized as key proteins responsible for the alleviation of DILI by FS and GM metabolites, with ESR1 emerging as a central target in the PPI network. The estrogen signalling pathway, particularly involving ESR1, ESR2 and JUN genes, was identified as a key mediator in the therapeutic effects. Four GM metabolites (baicalein, luteolin, lunularin and 2,3-bis(3,4-dihydroxybenzyl)butyrolactone) and two FS metabolites (pinoresinol and isolariciresinol) were identified as non-toxic, promising candidates. In conclusion, metabolites from FS and GM may exert a potent synergistic effect on DILI through modulation of the estrogen signalling pathway.

2025-12-01·Immunologic Research

PANoptosis-related genes in the prognosis and immune landscape of hepatocellular carcinoma

Article

作者: Qu, Liangchen ; Xue, Yuxiang ; Wu, Zhixuan ; Yuan, Ziwei ; Wang, Xiaowu ; Lin, Xingcheng ; Yang, Xuejia ; Wen, Zhikai ; Guo, Yangyang

In hepatocellular carcinoma (HCC) individuals, the influence of numerous variables on the HCC prognosis has gained widespread recognition. Nevertheless, there remains a need for further elucidation regarding the underlying mechanism of PANoptosis-related genes (PRGs) on HCC. A consensus clustering approach, based on the TCGA-LIHC data, was used to identify specific subtypes linked to PANoptosis in this study. Next, a signature consisting of predictive differentially expressed genes for these subtypes was established using a least absolute shrinkage and selection operator (LASSO) regression analysis. Additionally, the reliability of the signature was confirmed through verification investigations using the data from the ICGC database and TCGA-LIHC. In the end, we developed a nomogram to enhance the clinical effectiveness of our prediction tool. PRG signature in this study has been highly related to the prognosis of individuals diagnosed with HCC, which was established with six genes. Also, this signature and clinicopathological features were put together to create a nomogram. Interestingly, the forecasting efficiency of this combination approach is better than other prediction models in the reported literature. In addition, an examination of the immunological surroundings indicates that the group with low risk exhibited elevated ESTIMATE score, ImmuneScores, and StromalScores. More, significant differences in infiltrating immune cells and the expression levels of immune-related genes were found between the two groups. In HCC patients, the PRG signature exhibits potential as a biomarker, offering a significant point of reference for tailoring individual therapy.

2025-08-01·Tissue and Cell

Huanglian Jiedu Tang regulates the inflammatory microenvironment to alleviate the progression of breast cancer by inhibiting the RhoA/ROCK pathway

Article

作者: Yuan, Shaofei ; Chen, Xiaoqiang ; Lin, Qiuyan ; Zhu, Linjia

BACKGROUNDBreast cancer (BC) is a prevalent malignancy among women with strong heterogeneity. This study is designed to investigate the therapeutic effects of Huanglian Jiedu Tang (HLJDT) on BC progression and reveal its potential mechanism.METHODSThe effects of different concentrates of HLJDT on the viability, proliferation, migration, and invasion of BC cells were measured by CCK-8 assay, EdU staining, scratch test, and transwell assay, respectively. The levels of inflammatory factors and oxidative stress indicators were detected by ELISA. RhoA/ROCK pathway related protein was measured by western blot. A xenograft tumor model was constructed to explore the effects of HLJDT in vivo. Hematoxylin eosin staining was exploited to observe the pathological changes. Tumor proliferation was detected by immunohistochemistry (Ki67). Macrophage markers were detected by flow cytometry and RT-PCR. Furthermore, the ROCK agonist was used for feedback functional experiments.RESULTSThere was a concentration-dependent increase in the inhibitory impact of HLJDT on the viability, proliferation, migration, and invasion of BC cells (MCF-7 and MDA-MB-23). Moreover, HLJDT inhibit inflammation (TNF-α, IL-6 and IL-1β), oxidative stress (ROS, MDA and GSH) and RhoA/ROCK pathway. HLJDT regulated inflammatory microenvironment in BC, with increased IL-10, IL-4 levels and reduced TGF-β. In vivo, HLJDT restrained the tumor growth and proliferation, diminishing inflammatory infiltration and reducing malignancy. Additionally, HLJDT significantly increased F4/80 ⁺CD86 and iNOS levels, as well as the decreased F4/80 ⁺CD163 ⁺ and Arg1 levels. The treatment of ROCK agonist weakened the inhibitory effects of HLJDT on inflammation and BC progression.CONCLUSIONHLJDT may regulate inflammatory microenvironment to suppress BC progression through inhibiting the RhoA/ROCK pathway.

100 项与瑞安市人民医院相关的药物交易

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100 项与瑞安市人民医院相关的转化医学

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