Determining the utility of uraemic toxins in peritoneal dialysis to optimise patient care: interventional study looking at whether a high fibre diet reduces protein-bound uraemic toxins (PBUT) in peritoneal dialysis (PD) patients.

开始日期2023-10-19

申办/合作机构

The Monash Medical Centre

ACTRN12623000429651 / Not yet recruitingN/AIIT

Investigating the impact of a Neuro-Oncology nurse home visiting service on the well-being of patients with glioblastoma and on the need for hospital attendance.

开始日期2023-06-01

申办/合作机构

The Monash Medical Centre

ACTRN12622001405707 / Not yet recruiting临床2期IIT

Milrinone infusion for cerebral vasospasm in aneurysmal sub-arachnoid haemorrhage patients: a pilot randomised controlled study

开始日期2023-02-06

申办/合作机构

The Monash Medical Centre

100 项与 The Monash Medical Centre 相关的临床结果

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项与 The Monash Medical Centre 相关的文献（医药）

2024-10-01·Journal of the History of the Neurosciences

‘A divine right to photograph’: E. Graeme Robertson’s (1903–1975) historical motion pictures of National Hospital staff in 1933

Article

作者: Anderson, Neil E. ; Lees, Andrew J. ; Toodayan, Nadeem ; Robertson, Denis G.

In the course of researching and writing the first-ever book length biography of Edward Graeme Robertson's (1903-1975) eventful life and career in Australasian neurology, a rare 1933 cinema film recording of National Hospital staff at Queen Square has recently been rediscovered. Graeme completed his residency in neurology at Queen Square in the early 1930s and maintained close connections with his colleagues in London, thoughtfully recording them at different times using early movie cameras. Two versions of Graeme's 1933 film have been preserved, and there are also other color clips of his colleagues from later in life in the UCL Neurology archives and Robertson family collection. These remarkable films contain images of several historically significant neurologists, including Gordon Morgan Holmes (1876-1965), Samuel Alexander Kinnier Wilson (1878-1937), Derek Denny-Brown (1901-1981), Macdonald Critchley (1900-1997), and several others. We provide a contextual summary of the many clips recorded alongside an in-depth inventory of all the personalities represented in the 1933 film. Selected photographs are used to indicate the contents of these remarkable films.

2024-10-01·Vascular and Endovascular Surgery

Transarterial Embolisation of Abdominal Aortic Type II Endoleaks Accessed via the Deep Circumflex Iliac Artery: A Case Series and Literature Review

Review

作者: Weeratunga, Senali ; De Boo, Diederick Willem ; Anning, Naomi ; Puttaswamy, Vikram ; Wang, Yunyi

We report our technique and experience treating 3 patients with native abdominal aortic aneurysm (AAA) sac expansion following EVAR, who were managed with transarterial embolisation via the deep circumflex iliac artery (DCIA). In this case series, we demonstrate that transarterial embolisation via the DCIA is a feasible and safe treatment option. The DCIA should be routinely interrogated with angiography as not only a cause of possible Type II endoleak, but also to identify a potential access route to the abdominal aortic sac for interventional treatment.

2024-09-26·Journal of Bone and Mineral Research

Prevalence of HIV-associated osteoporosis and fracture risk in midlife women: a cross-sectional study in Zimbabwe

Article

作者: Gregson, Celia L ; Ward, Kate A ; Ferrand, Rashida A ; Madanhire, Tafadzwa ; Kahari, Cynthia ; Kowo-Nyakoko, Farirayi ; Ó Breasail, Mícheál ; Ebeling, Peter R

AbstractAntiretroviral therapy roll-out has dramatically reduced HIV-related mortality; more women are living to reach menopause. Menopausal estrogen loss causes bone loss, as does HIV and some of its treatments. However, data describing HIV’s impact on osteoporosis prevalence and fracture risk are scarce in southern Africa. A cross-sectional study of women aged 40-60 years (49% women with HIV [WLH]) was conducted in Harare, Zimbabwe. Menopause, fracture, and HIV history were collected, and anthropometry and BMD (by DXA) measured, and FRAX 10-year fracture probabilities quantified. The FRAX probability of a major osteoporotic fracture (MOF) included HIV as a risk factor for secondary osteoporosis. Linear and Poisson regression determined the relationships between clinical risk factors and both femoral neck (FN) BMD and the 10-year FRAX probability of MOF respectively. The 393 participants had a mean (SD) age of 49.6 (5.8) years and mean (SD) BMI of 29.1 (6.0) kg/m2. 95% of WLH were antiretroviral therapy (ART) established (85% tenofovir disoproxil fumarate) and 81% had a viral load <50 copies/mL. A BMD T-score ≤ –2.5 was more common in WLH than those without, at both FN and lumbar spine (LS) (FN, 22 [11.4%] vs 5 [2.5%]; LS, 40 [20.8%] vs 9 [4.5%], respectively). Prior fracture was more prevalent in WLH: any fracture type (27 [14%] vs 14 [7%]); MOF (14 [7.3%] vs 5 [2.5%]). WLH had a higher 10-year MOF probability (median, 1.2%; IQR, 0.9-1.8) compared with those without HIV (1.0%; IQR, 0.9-1.5) (p < .001), although probabilities were low. Older age, low weight, and HIV infection were strongly associated with lower FN BMD. Higher probability of MOF was associated with older age, HIV infection, parental hip fracture and prior fracture, although adjustment attenuated the association with HIV. No woman reported anti-osteoporosis medication use. While osteoporosis and previous fractures were common and untreated in this relatively young population, particularly in WLH, the FRAX-predicted 10-year MOF risk was low. Clinical risk factors considered in fracture risk prediction tools in Zimbabwe may need contextual modification.

项与 The Monash Medical Centre 相关的新闻（医药）

2022-09-01

·mobihealthnews

Study trains AI to predict optimal anti-seizure meds for new epilepsy patients

An international study led by Monash University has done what could be the world's first demonstration of an AI model that can predict the optimal anti-seizure medication for newly diagnosed epilepsy patients. WHAT IT'S ABOUT The research team has trained a deep-learning prediction model using clinical information from around 1,800 patients in five health care centres in Australia, Malaysia, China and the United Kingdom. The model is designed by the Monash Medical AI Group and is trained using Monash's MASSIVE computing facility. Findings from the study, which was published in the journal JAMA Neurology, showed that the AI model has a "modest" 65% accuracy in predicting the best anti-seizure medication. The research team is still improving the model by employing more complex information. Later, the enhanced predictive model will be tested in a national, multi-site randomised controlled trial called PERSONAL (Personalised Selection of Medication for Newly Diagnosed Adult Epilepsy). According to Monash, the said trial, which has received a A$2.46 million ($1.7 million) grant from the Australian government's National Health and Medical Research Council, is designed to predict responses to epilepsy treatment, not actual seizures. WHY IT MATTERS About 70 million people around the world have epilepsy. Until now, there has been a lot of guesswork and experimentation by doctors on which anti-seizure drugs their patients will respond to, said Patrick Kwan, professor and neurologist from the Monash Central Clinical School’s Department of Neuroscience, who is leading the international study. He added that this trial-and-error process could harm patients more than benefit them. Side effects may range from allergies to psychiatric problems, or in the case of women, birth defects in their babies. Dr Zhibin Chen, neuroscientist and biostatistician from Monash, said their AI model "will open the gate for personalising the management of epilepsy". Currently, the predictive model is intended for adults with new-onset epilepsy who are about to begin their medication. Monash said the model will serve as a basis for future models for people with more established epilepsy. THE LARGER TREND Research in India has produced novel algorithms that can spot the source of epileptic seizures using a patient's EEG data. Developed by researchers from the Indian Institute of Technology – Delhi, the head harmonics-based array processing algorithms can pinpoint coordinates of seizure within minutes. These algorithms have been validated in a study that was recently published in Nature Scientific Reports. Wearable technology is the latest in epileptic seizure detection, such as Epitel's REMI system, which consists of a wireless EEG sensor that is worn below the hairline and software for providers to review data and monitor seizures. Early this year, the US-based company scored $12.5 million in Series A funding to commercialise its product.