The goal of this study is to determine how these techniques affect pain levels, movement quality, and balance. Osteopathic Manipulative Techniques, or OMT, is a type of treatment used to treat problems in the bones, muscles, tissues, and joints. The investigators would like to ask the participants to fill out a few questionnaires about their personal history, dance background, pain levels, and movement quality. All participant responses will be completely anonymous, and participants are allowed to refuse to answer any part of the survey. The investigators would also ask participants to complete a balance assessment, which will involve standing on a force plate with their eyes open and closed for 30 seconds each. The initial survey and questionnaires, balance assessment, OMT, and post-practice survey are expected to take about 60 minutes. Each additional survey given after 24-hours and one week will take about 20 minutes each. The follow-up balance test after one week is expected to take less than 5 minutes. Participation in this study would be immensely valuable for us to learn more about the benefits of treating dancers with osteopathic manipulative medicine.

开始日期2025-02-01

申办/合作机构

Edward Via College of Osteopathic Medicine

[+1]

NCT04506333

/ Unknown statusN/AIIT

Validation of the A&D UA-651 Oscillometric Blood Pressure Monitor in Children

This study will determine if the A&D UA-651 blood pressure monitor is valid in children.

开始日期2020-08-01

申办/合作机构

University of Louisiana at Monroe

NCT04098978

/ CompletedN/AIIT

Before-after Comparison of Pharmacist Drug Therapy Management in Pediatric Hypertension

This study will measure the effect of a novel pharmacy practice model on pediatric patients with hypertension. In North Louisiana, many patients have to travel to see subspecialists for treatment for hypertension and elevated blood pressure, which has many costs including direct medical costs, direct nonmedical costs, and indirect costs like missed time from work, school, or social obligations. Also, many patients who have to travel to get to their appointments have a high rate of missed appointments, which can be bad for overall health.
This study will use a pharmacist to perform collaborative drug therapy management with pediatric cardiologists to manage therapy for patients with hypertension or elevated blood pressure. Patients will monitor blood pressure at home and follow up with the pharmacist by telecommunications. Pharmacist drug therapy management and telemedicine have been studied separately, but this is the first study with pharmacist drug therapy management by telemedicine for pediatric patients. If this model is successful, it could be replicated in other rural areas to improve patient care and reduce healthcare costs.

开始日期2020-01-14

申办/合作机构

University of Louisiana at Monroe

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1,722

项与 University of Louisiana at Monroe 相关的文献（医药）

2025-10-01·PLANT SCIENCE

Physiological and transcriptional changes in soybean as adaptive responses to the combined effects of soil alkalinity and drought

Article

作者: Mostofa, Mohammad Golam ; Thapa, Asha ; Kabir, Ahmad H ; Hasan, Md Rokibul

Soil alkalinity and drought collectively cause severe growth retardation in crops. However, the adaptive responses and transcriptional changes under such conditions remain unclear in soybean. In this growth incubator study, soil alkalinity and drought stress led to significant reductions in plant biomass, chlorophyll, and nutrient uptake in soybean. However, the photochemical efficiency of photosystem II remained stable, suggesting the activation of protective mechanisms to maintain photosynthetic functions. RNA-seq analysis demonstrated 357 upregulated and 799 downregulated genes in roots due to combined soil alkalinity and drought. Analysis revealed a complex response, with upregulation of genes predominantly involved in mineral homeostasis (Iron dehydrogenase, Sulfurylase), reactive oxygen species scavenging (Glutamate synthase, L-Ascorbate peroxidase) and hormonal signaling. Particularly, several ethylene-responsive genes, including the Transcription factors TF5 and TF018, were upregulated, indicating the activation of stress-related signaling pathways. In a targeted study, plants supplemented with an ethylene precursor showed significant improvements in morpho-physiological traits and Fe status under combined stress. However, ethylene precursor applied in non-stressed plants led to reduced growth, and Fe levels, suggesting an involvement of the context-dependent role of ethylene in promoting stress tolerance. Furthermore, ethylene precursors caused an increase in root flavonoid and rhizosphere siderophore while restoring bacterial and fungal microbial cells in roots under combined stress in soil. However, in healthy plants, flavonoid and siderophore levels decreased, accompanied by a reduction in microbial cells to control levels. This suggests that elevated ethylene may regulate root exudates to recruit microbes dominated by host response, aiding soybean plants cope with combined stresses, although this effect may not occur in non-stressed plants. These findings may contribute to advancing knowledge for genetic and agronomic interventions aimed at improving stress resilience in soybean exposed to soil alkalinity and drought.

2025-08-01·BIOORGANIC CHEMISTRY

Design, novel one-pot green synthesis, and biological evaluation of pyrazolopyridine-congeners selectively targeting HER2+ breast cancer

Article

作者: Ali, Hamed I ; Albohy, Amgad ; Khan, Ishaq ; Abd Elmageed, Zakaria Y ; Allam, Heba Abdelrasheed ; Ezzat, Manal Abdel Fattah ; Mogheith, Samar M ; Mohamady, Samy ; Fandy, Tamer E ; Dawud, Dalal

Breast cancer (BC) is among the most prevalent and most aggressive cancer types affecting females. Several targets were investigated to tackle this problem, among them HER2 receptors are one on the most studied targets. In this study we report the synthesis of 18 different pyrazolopyridine (3a-r) derivatives using a novel green one-pot method. The synthesized compounds were screened against NCI 60 human tumor cell panel at single concentration. The six top compounds (3c, 3d, 3f, 3l, 3m and 3o) were followed up by plotting their IC₅₀ values and selectivity indices against different cancer types. Kinase profiling for the top two compounds (3f and 3o) was done against 20 different kinases and showed that they have selective inhibition of HER2 (with -88 and - 75 % inhibition) comparable to Tucatinib (-90 % inhibition). In addition, Annexin V PI/FITC apoptosis assay using BT474 cell lines on compounds 3l, 3o and 3f demonstrate the target specificity of our most potent compounds towards HER2 + ve harboring cells. In vivo antitumor activity of compound 3f on BC xenograft mouse model demonstrates that the recorded tumor size over the course of study was significantly reduced by 19.45 % when mice treated with 3f compared to 38.6 % reduction when treated with lapatinib. Finally molecular docking and molecular dynamics studies were used to investigate and understand the potential binding modes and interactions between the synthesized compounds and HER2 on the molecular level. In summary, this study presents the synthesis of this new promising scaffold as anti breast cancer medication using a novel green one-pot method.

2025-08-01·EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT

The Impact of Attentiveness Interventions on Survey Data

Article

作者: Wall, Alison ; Fuller, Christie M. ; Ragland, Elizabeth ; Twitchell, Douglas P. ; Simmering, Marcia J. ; Waterwall, Brian

Social and behavioral science researchers who use survey data are vigilant about data quality, with an increasing emphasis on avoiding common method variance (CMV) and insufficient effort responding (IER). Each of these errors can inflate and deflate substantive relationships, and there are both a priori and post hoc means to address them. Yet, little research has investigated how both IER and CMV are affected with the use of these different procedural or statistical techniques used to address them. More specifically, if interventions to reduce IER are used, does this affect CMV in data? In an experiment conducted both in and out of the laboratory, we investigate the impact of attentiveness interventions, such as a Factual Manipulation Check (FMC) on both IER and CMV in same-source survey data. In addition to typical IER measures, we also track whether respondents play the instructional video and their mouse movement. The results show that while interventions have some impact on the level of participant attentiveness, these interventions do not appear to lead to differing levels of CMV.

项与 University of Louisiana at Monroe 相关的新闻（医药）

2020-03-19

·SYNAPSE

Bluefield College and VCOM Sign Agreement

The Bluefield College Board of Trustees voted this month to further align Bluefield College with the Edward Via College of Osteopathic Medicine (VCOM) family of schools by joining its education consortium. Representatives of the two higher education institutions jointly announced the agreement in a March 19 announcement in the Chandler Boardroom at Bluefield College. “Bluefield College has been fortunate to have VCOM as a valued, key partner for a number of years,” said President David W. Olive. “We believe that God has ordered our steps to bring us to this place in our relationship.” Through this agreement with the educational consortium, Bluefield College will retain its name, will remain a separate 501(c)(3) entity with assets and liabilities intact, and will continue its Christ-centered mission and covenant relationship with the Baptist General Association of Virginia (BGAV). The BGAV, alongside local community leaders, founded Bluefield College in 1922 as a college serving students in Appalachia. Further, the governing board will continue to guide the direction of the College. Non-governing boards, such as the Alumni Association Board of Directors, President’s Advisory Council, and others will continue as they currently operate. “Students should see that nothing will change regarding their educational and co-curricular experiences at Bluefield College,” said Olive. “We do anticipate a benefit of capital improvements to campus facilities, and assuming no one chooses to leave, the same faculty and staff will continue to serve.” Bluefield College currently offers a Master of Arts degree in Biomedical Sciences (MABS) on the Edward Via College of Osteopathic Medicine (VCOM) Virginia campus. Its purpose is to enhance academics to gain acceptance into a medical school or other healthcare programs through a nine-month, 35-credit hour, face-to-face delivery program. The program places emphasis on biomedical coursework, research experience, field study, as well as seminars in professional development. As part of the agreement, the new revenue for the College for Capital improvements will come from the development of new science and health sciences programs that provide pathways to medical school and other healthcare professions. With Bluefield and VCOM being supported by the same foundation, programs for both Bluefield and VCOM students will be jointly developed to offer degrees for those seeking research careers in the future. The agreement to restructure will require approval from Bluefield College’s accreditor, the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) and the U.S. Department of Education. Bluefield College will immediately begin working more closely with VCOM in the weeks following the announcement. The restructuring, if approved, will seek to be implemented in January 2021 by Bluefield and the foundation that also owns VCOM. The accreditation of VCOM will remain independent of Bluefield, and with the Commission of Osteopathic College Accreditation (COCA), the only USDE approved accreditor for osteopathic medical schools. “The mission of VCOM and Bluefield College align very closely. The collaboration and partnership possibilities are endless as one family of schools.” The Edward Via College of Osteopathic Medicine (VCOM) is a four-year osteopathic medical school offering the Doctor of Osteopathic Medicine (D.O.) degree. VCOM’s mission is to prepare globally-minded, community-focused physicians to meet the needs of rural and medically underserved populations and promote research to improve human health. Osteopathic physicians are licensed in every state to practice the full scope of medicine including examining patients, diagnosing illness, writing prescriptions, performing surgery, as well as providing musculoskeletal manipulation. Osteopathic physicians enter every field of medicine from family practice to neurosurgery. The majority of osteopathic physicians practice primary care, with approximately one-fourth of the profession providing care in small communities and rural areas. The school has four campuses in Blacksburg, Virginia; Spartanburg, South Carolina; Auburn, Alabama; and Monroe, Louisiana. Bluefield College is a Christ-centered learning community preparing servant-leaders. It offers a challenging academic and co-curricular experience within a climate of diverse Christian tradition. The College is committed to developing students’ potential through academic excellence and the integration of faith, the liberal arts, career-oriented programs, and service to God and the global community. Bluefield College is accredited by SACSCOC, and boasts over forty academic offerings from associate level to master level degrees. The College is located in the Appalachian Mountains of southwest Virginia in Bluefield, Virginia. VCOM President and Provost Dixie Tooke-Rawlins stated: “The addition of Bluefield College within the foundation’s ownership will not negatively impact VCOM’s other University public-private partnerships such as Virginia Tech, Auburn University, or the University of Louisiana Monroe. In fact, we are hopeful that this will offer recruitment from Bluefield graduates into those universities’ other professional programs as well. In the past decade, we have seen challenges to the U.S. private colleges and collaboration on both educational programs and research are needed to maintain private colleges that are located in the rural areas of our states.

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