The goal of this study is to determine how these techniques affect pain levels, movement quality, and balance. Osteopathic Manipulative Techniques, or OMT, is a type of treatment used to treat problems in the bones, muscles, tissues, and joints. The investigators would like to ask the participants to fill out a few questionnaires about their personal history, dance background, pain levels, and movement quality. All participant responses will be completely anonymous, and participants are allowed to refuse to answer any part of the survey. The investigators would also ask participants to complete a balance assessment, which will involve standing on a force plate with their eyes open and closed for 30 seconds each. The initial survey and questionnaires, balance assessment, OMT, and post-practice survey are expected to take about 60 minutes. Each additional survey given after 24-hours and one week will take about 20 minutes each. The follow-up balance test after one week is expected to take less than 5 minutes. Participation in this study would be immensely valuable for us to learn more about the benefits of treating dancers with osteopathic manipulative medicine.

开始日期2025-02-01

申办/合作机构

Edward Via College of Osteopathic Medicine

[+1]

NCT04506333

/ Unknown statusN/AIIT

Validation of the A&D UA-651 Oscillometric Blood Pressure Monitor in Children

This study will determine if the A&D UA-651 blood pressure monitor is valid in children.

开始日期2020-08-01

申办/合作机构

University of Louisiana at Monroe

NCT04098978

/ CompletedN/AIIT

Before-after Comparison of Pharmacist Drug Therapy Management in Pediatric Hypertension

This study will measure the effect of a novel pharmacy practice model on pediatric patients with hypertension. In North Louisiana, many patients have to travel to see subspecialists for treatment for hypertension and elevated blood pressure, which has many costs including direct medical costs, direct nonmedical costs, and indirect costs like missed time from work, school, or social obligations. Also, many patients who have to travel to get to their appointments have a high rate of missed appointments, which can be bad for overall health.
This study will use a pharmacist to perform collaborative drug therapy management with pediatric cardiologists to manage therapy for patients with hypertension or elevated blood pressure. Patients will monitor blood pressure at home and follow up with the pharmacist by telecommunications. Pharmacist drug therapy management and telemedicine have been studied separately, but this is the first study with pharmacist drug therapy management by telemedicine for pediatric patients. If this model is successful, it could be replicated in other rural areas to improve patient care and reduce healthcare costs.

开始日期2020-01-14

申办/合作机构

University of Louisiana at Monroe

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项与 University of Louisiana at Monroe 相关的文献（医药）

2026-03-05·JOURNAL OF PHYSICAL CHEMISTRY A

Photoelectron Imaging Spectroscopy of C ₆ Cl _x F _{6–
x} ^– ( x = 2, 3, 5) and C ₂ Cl ₄ ^– Anions: Charge Localization or Delocalization─That Is the Question

Article

作者: Jarrold, Caroline Chick ; McGinnis, Kristen Rose ; Aiena, Raegan M. ; McGee, Conor J. ; Sommerfeld, Thomas

New photoelectron (PE) spectra of C₆Cl_xF_6-x^- (x = 2, 3, 5) are presented and compared with previously reported PE spectra of C₆F₆^- and C₆ClF₅^-, along with the known properties of C₆Cl₆^-. Based on a recent theoretical study [J. Phys. Chem. A 2024, 128, 8072-8079], anions of the mixed perchlorofluorobenzenes have competing molecular and electronic structures: one in which the electron is localized in a single C-Cl σ* orbital, resulting in a structure with a uniquely elongated C-Cl bond, and the other in which the excess charge is more delocalized, resulting in a more symmetric anion. In all cases, the experimental PE spectra are consistent with the former, with the exception of C₆Cl₅F^-, the spectrum of which is not consistent with calculations on either structure. The adiabatic electron affinities of the neutrals are difficult to ascertain from the anion PE spectra because of vanishingly small signal near the origin. However, the vertical detachment energies are determined to be 3.20(10) eV for C₆Cl₂F₄^-, 3.09(5) eV for C₆Cl₃F₃^-, and 1.85(10) eV for C₆Cl₅F^-. The VDEs of C₆Cl₂F₄^- and C₆Cl₃F₃^- are similar to the previously reported VDE of C₆ClF₅^-, 2.95 eV [J. Phys. Chem. A 2024, 128, 5646-5658], and significantly higher than the previously reported VDE determined from the PE spectrum of C₆F₆^-, 1.60 eV, measured on the same instrument [J. Phys. Chem. A 2023, 127, 556-8565]. To further benchmark the computational methods and gain insights into the relationship between the anionic structures in which the excess charge is localized in a single C-Cl σ* orbital and the delocalized structure, we measured the PE spectrum C₂Cl₄^-, which exhibited a VDE consistent with the computed structure in which the excess charge is localized in a single C-Cl σ* orbital, and which was the computed lowest energy structure of C₂Cl₄^-. We further explore the relationship between localized and delocalized structures in this molecular anion and C₆Cl₅F^-.

2026-02-01·COMPUTATIONAL BIOLOGY AND CHEMISTRY

Discovery of pyrazole derivatives as promising leads against NSCLC: An integrated computational and experimental approach

Article

作者: Afroja, Fahima ; GholamianMoghaddam, Ali ; Siriki, Atchimnaidu ; Murru, Siva

Lung cancer remains a leading cause of cancer-related mortality worldwide, with non-small cell lung carcinoma (NSCLC) representing the predominant subtype. Despite advances in targeted therapies, the development of potent and selective small-molecule therapeutics for NSCLC remains a key challenge in drug discovery. In this study, we designed and computationally evaluated a focused library of pyrazole-based derivatives as potential anticancer agents. A rational, multi-step in silico workflow integrating target prediction, molecular docking, and drug-likeness assessment was employed to identify promising candidates. Twelve pyrazole derivatives were docked against multiple NSCLC-relevant protein kinases, and their ADME properties were predicted using SwissADME webserver. Among these, PL-13 emerged as a lead candidate and was subsequently synthesized, structurally characterized, and evaluated in vitro. Cytotoxicity studies using the MTT assay demonstrated that PL-13 exhibits potent antiproliferative activity against A549 NSCLC cells while maintaining favorable selectivity over non-cancerous HFL-1 fibroblasts. These findings highlight pyrazole-based scaffolds as promising leads for NSCLC drug discovery and establish PL-13 as a valuable starting point for further SAR-driven optimization.

2026-01-13·AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY

Collaborative Relationships Between Families and Speech-Language Pathologists Within Family-Centered Early Intervention

Article

作者: Damico, Holly ; Damico, Jack ; Nelson, Ryan ; Koch, Kelly

Purpose::

The purpose of this study was to generate a theory, grounded in data, explaining the collaborative relationships between speech-language pathologists and families in family-centered early intervention.

Method::

Using constructivist grounded theory methodology, three pairs of clinicians and families allowed participatory observations, video recording of sessions, parent interviews, clinician interviews, and documentation collection. Seven additional pairs of clinicians and families were interviewed, culminating in 20 total interviews. Data were analyzed using the constant comparative method, and a substantive theory emerged.

Results::

From this data set, the substantive theory is that family–professional collaborative relationships are established and maintained by participants in family-centered early intervention via a constant process of feedback loops. These loops are cyclical social interactions, incorporating each of the participants' backgrounds and building shared knowledge with informational interactions, in which the participants establish and meet expectations and give and accept agency from each of the participants.

Conclusions::

The individual relationships varied, as shown in the variation of the themes in individual experiences. The collaborative clinical relationship at the heart of family-centered early intervention, however, requires the continual process of feedback between social interactions, background, informational interactions, expectations, and agency to be considered by professionals.

Supplemental Material::

https://doi.org/10.23641/asha.30429991

项与 University of Louisiana at Monroe 相关的新闻（医药）

2020-03-19

·SYNAPSE

Bluefield College and VCOM Sign Agreement

The Bluefield College Board of Trustees voted this month to further align Bluefield College with the Edward Via College of Osteopathic Medicine (VCOM) family of schools by joining its education consortium. Representatives of the two higher education institutions jointly announced the agreement in a March 19 announcement in the Chandler Boardroom at Bluefield College. “Bluefield College has been fortunate to have VCOM as a valued, key partner for a number of years,” said President David W. Olive. “We believe that God has ordered our steps to bring us to this place in our relationship.” Through this agreement with the educational consortium, Bluefield College will retain its name, will remain a separate 501(c)(3) entity with assets and liabilities intact, and will continue its Christ-centered mission and covenant relationship with the Baptist General Association of Virginia (BGAV). The BGAV, alongside local community leaders, founded Bluefield College in 1922 as a college serving students in Appalachia. Further, the governing board will continue to guide the direction of the College. Non-governing boards, such as the Alumni Association Board of Directors, President’s Advisory Council, and others will continue as they currently operate. “Students should see that nothing will change regarding their educational and co-curricular experiences at Bluefield College,” said Olive. “We do anticipate a benefit of capital improvements to campus facilities, and assuming no one chooses to leave, the same faculty and staff will continue to serve.” Bluefield College currently offers a Master of Arts degree in Biomedical Sciences (MABS) on the Edward Via College of Osteopathic Medicine (VCOM) Virginia campus. Its purpose is to enhance academics to gain acceptance into a medical school or other healthcare programs through a nine-month, 35-credit hour, face-to-face delivery program. The program places emphasis on biomedical coursework, research experience, field study, as well as seminars in professional development. As part of the agreement, the new revenue for the College for Capital improvements will come from the development of new science and health sciences programs that provide pathways to medical school and other healthcare professions. With Bluefield and VCOM being supported by the same foundation, programs for both Bluefield and VCOM students will be jointly developed to offer degrees for those seeking research careers in the future. The agreement to restructure will require approval from Bluefield College’s accreditor, the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) and the U.S. Department of Education. Bluefield College will immediately begin working more closely with VCOM in the weeks following the announcement. The restructuring, if approved, will seek to be implemented in January 2021 by Bluefield and the foundation that also owns VCOM. The accreditation of VCOM will remain independent of Bluefield, and with the Commission of Osteopathic College Accreditation (COCA), the only USDE approved accreditor for osteopathic medical schools. “The mission of VCOM and Bluefield College align very closely. The collaboration and partnership possibilities are endless as one family of schools.” The Edward Via College of Osteopathic Medicine (VCOM) is a four-year osteopathic medical school offering the Doctor of Osteopathic Medicine (D.O.) degree. VCOM’s mission is to prepare globally-minded, community-focused physicians to meet the needs of rural and medically underserved populations and promote research to improve human health. Osteopathic physicians are licensed in every state to practice the full scope of medicine including examining patients, diagnosing illness, writing prescriptions, performing surgery, as well as providing musculoskeletal manipulation. Osteopathic physicians enter every field of medicine from family practice to neurosurgery. The majority of osteopathic physicians practice primary care, with approximately one-fourth of the profession providing care in small communities and rural areas. The school has four campuses in Blacksburg, Virginia; Spartanburg, South Carolina; Auburn, Alabama; and Monroe, Louisiana. Bluefield College is a Christ-centered learning community preparing servant-leaders. It offers a challenging academic and co-curricular experience within a climate of diverse Christian tradition. The College is committed to developing students’ potential through academic excellence and the integration of faith, the liberal arts, career-oriented programs, and service to God and the global community. Bluefield College is accredited by SACSCOC, and boasts over forty academic offerings from associate level to master level degrees. The College is located in the Appalachian Mountains of southwest Virginia in Bluefield, Virginia. VCOM President and Provost Dixie Tooke-Rawlins stated: “The addition of Bluefield College within the foundation’s ownership will not negatively impact VCOM’s other University public-private partnerships such as Virginia Tech, Auburn University, or the University of Louisiana Monroe. In fact, we are hopeful that this will offer recruitment from Bluefield graduates into those universities’ other professional programs as well. In the past decade, we have seen challenges to the U.S. private colleges and collaboration on both educational programs and research are needed to maintain private colleges that are located in the rural areas of our states.

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