Delving into the Latest Updates on Shahed University with Synapse

Investigating the additive effects of De-addicta to methadone on treatment retention and craving in patients with opioid use disorder under methadone maintenance treatment referring to opioid agonist treatment outpatient clinics; 3 months intervention (first phase)

开始日期2024-11-10

申办/合作机构

Shahed University

IRCT20240705062335N1 / SuspendedN/AIIT

Calculating the Contribution of Flexibility Components in Predicting Sexual Distress and Satisfaction Based on Intimacy and Attachment Orientation in Men with Sexual Dysfunction and Investigating the Efficacy of Acceptance and Commitment Therapy Based on the Most Contributions Components on Sexual Distress and Satisfaction in Men Recovered from Peyronie's Disease

开始日期2024-09-22

申办/合作机构

Shahed University

IRCT20110420006243N5 / Recruiting临床3期IIT

Comparison effect of permethrin shampoo to permethrin shampoo with vinegar in the treatment of head lice in children aged 6-13 years

开始日期2024-09-22

申办/合作机构

Shahed University

100 项与 Shahed University 相关的临床结果

登录后查看更多信息

0 项与 Shahed University 相关的专利（医药）

登录后查看更多信息

6,482

项与 Shahed University 相关的文献（医药）

2025-02-01·Protein Expression and Purification

Anti-biofilm and antibacterial effect of bacteriocin derived from Lactobacillus plantarum on the multidrug-resistant Acinetobacter baumannii

Article

作者: Javadi, Kasra ; Halaji, Mehrdad ; Parsian, Hadi ; Pournajaf, Abazar ; Emadzadeh, Mohammad Reza ; Mohammadzadeh Hosseini Moghri, Seyed Amir Hossein ; Rajabnia, Mehdi

This research examines the impact of bacteriocin derived from Lactobacillus plantarum PTCC 1745 on the biofilm formations of A. baumannii isolates. Bacteriocin derived from L. plantarum PTCC 1745 was obtained through ammonium sulfate precipitation, cation-exchange chromatography, and reversed-phase high-performance liquid chromatography (RP-HPLC). Testing for bacteriocin susceptibility has been conducted using the broth dilution method. The anti-biofilm activity of bacteriocin was evaluated using a microtiter plate method. Quantitative real-time PCR assay evaluated bap gene expression in bacteriocin-treated cells. According to SDS-PAGE, bacteriocin from L. plantarum has a 25-kDa apparent molecular weight. The MICs of bacteriocin ranged from 30 to 120 μg/mL, while the MBCs varied between 60 and 120 μg/mL. Compared to the non-treated group, strains bacteriocin-treated isolates had 59 % less ability to form biofilm. The mean relative expression of the bap gene among the MDR A. baumannii isolates decreased by 52 % compared to the untreated control. This study demonstrated that bacteriocin derived from L. plantarum PTCC 1745 had antibacterial and antibiofilm activity against MDR A. baumannii isolates.

2024-12-01·Molecular Biology Reports

Exosomes as modulators of embryo implantation

Review

作者: Saberi, Fatemeh ; Darya, Gholamhossein ; Rezaee, Delsuz ; Noori, Effat ; Dehghan, Zeinab ; Pilehchi, Tayyebeh ; Taheri, Zahra ; Mehdinejadiani, Shayesteh

Exosomes, known as extracellular vehicles (EVs), are found in biological fluids. They have the capability to carry and transfer signaling molecules, such as nucleic acids and proteins, facilitating intercellular communication and regulating the gene expression profile in target cells. EVs have the potential to be used as biomarkers in diagnosis, prognosis and also as feasible therapeutic targets. The available evidence suggests that exosomes play critical roles in the reproductive system, particularly during implantation, which is widely recognized as a crucial step in early pregnancy. A proper molecular dialogue between a high-quality embryo and a receptive endometrium is essential for the establishment of a normal pregnancy. This review focuses on the key role of exosomes originated from various sources, including the embryo, seminal fluid, and uterus fluid, based on the available evidence. It explores their potential applications as a novel approach in assisted reproductive technologies (ART).

2024-12-01·Global Medical Genetics

Human Viral Oncoproteins and Ubiquitin–Proteasome System

Review

作者: Faghihloo, Ebrahim ; Hosseini, Sareh Sadat ; Atani, Zahra Rafiei ; Goudarzi, Hossein

AbstractSome human cancers worldwide may be related to human tumor viruses. Knowing, controlling, and managing the viruses that cause cancers remain a problem. Also, tumor viruses use ubiquitin–proteasome system (UPS) that can alter host cellular processes through UPS. Human tumor viruses cause persistent infections, due to their ability to infect their host cells without killing them. Tumor viruses such as Epstein–Barr virus, hepatitis C virus, hepatitis B virus, human papillomaviruses, human T cell leukemia virus, Kaposi's sarcoma-associated herpesvirus, and Merkel cell polyomavirus are associated with human malignancies. They interfere with the regulation of cell cycle and control of apoptosis, which are important for cellular functions. These viral oncoproteins bind directly or indirectly to the components of UPS, modifying cellular pathways and suppressor proteins like p53 and pRb. They can also cause progression of malignancy. In this review, we focused on how viral oncoproteins bind to the components of the UPS and how these interactions induce the degradation of cellular proteins for their survival.

100 项与 Shahed University 相关的药物交易

登录后查看更多信息

100 项与 Shahed University 相关的转化医学

登录后查看更多信息