Trocar site incisional hernia (TSIH) is the most frequent complication associated to laparoscopic surgery. Few studies currently describes its real prevalence or risk factors. The aim of this study is to determine the real incidence of TSIH and to identify risk factors in the investigator's series of patients.
A cross sectional, prospective study is performed including consecutive patients who underwent a laparoscopic procedure during a four months period. All the patients are assessed both clinically (TSIHc) and by an ultrasonographic exam (TSIHu). Main variable studied is the incidence of TSIH. A multivariate analysis is performed to identify risk factors.

开始日期2015-06-02

申办/合作机构

Hospital de Mataró

NCT01383694

/ Completed临床1/2期IIT

Effect of Natural Agonists of TRPV1 in the Treatment of Functional Oropharyngeal Dysphagia in Neurological Diseases and the Elderly: Piperine

Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.

开始日期2011-06-01

申办/合作机构

Hospital de Mataró

NCT01850173

/ CompletedN/AIIT

Effects of Whole Body Vibration Training in Severe Chronic Obstructive Pulmonary Disease Patients

The investigators designed the current study with the main objective of determining whether Whole Body Vibration Training (WBVT) alone improves muscular force and/or modifies the functional capacity parameters in severe Chronic Obstructive Pulmonary Disease (COPD) patients referred to a rehabilitation programme.

开始日期2010-02-01

申办/合作机构

Hospital de Mataró

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102

项与 Hospital de Mataró 相关的文献（医药）

2025-04-01·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Bioenergetic markers in cerebrospinal fluid in first-episode psychosis: Are they predictors of early antipsychotic response and 1-year outcomes?

Article

作者: Daví-Loscos, Eva ; Martínez-Ramírez, María ; Cuesta, Manuel J ; Ballesteros, Alejandro ; Guanyabens, Nicolau ; Boix-Quintana, Ester ; Giné-Servén, Eloi ; Labad, Javier ; Crespo-Facorro, Benedicto ; Casado, Virginia

Psychotic disorders involve complex pathophysiological mechanisms, and identification of biomarkers for treatment response remains a major challenge. We aimed to study whether routine cerebrospinal fluid (CSF) parameters measured at baseline predict poor early response at 2 weeks with optimal antipsychotic treatment doses in patients with first-episode psychosis (FEP). We also explored whether these parameters could predict changes in social functioning and psychopathology over a 1-year follow-up. Ninety-eight inpatients with FEP who had received less than 6 weeks of antipsychotic treatment were included in the study. A lumbar puncture was performed at the index admission to measure CSF parameters (glucose, total protein, and lactate dehydrogenase [LDH]). The Positive and Negative Syndrome Scale (PANSS) was administered. A poor early treatment response at week 2 was defined as a < 20 % reduction in the PANSS positive subscore of a consensus factor. Social functioning was assessed using the Personal and Social Performance Scale (PSP) at baseline and 2, 4, 6, 9, and 12 months. Statistical analyses explored the role of CSF biomarkers in early treatment response using logistic regression and long-term social functioning and psychopathology using mixed linear regression analyses. Eighteen patients with FEP (18.4 %) were nonresponders at week 2. The CSF LDH concentration was a predictor of early treatment nonresponse. Higher CSF LDH concentrations were associated with a reduced improvement in social functioning at month 2, and higher CSF glucose concentrations were associated with lower reductions in the PANSS total scores at all visits. These findings suggest that specific bioenergetic parameters in the CSF, such as LDH and glucose, may serve as prognostic biomarkers for early treatment response and 1-year social and psychopathological outcomes in patients with FEP.

2025-04-01·Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Model to predict the risk of cardiac death based on clinical characteristics and Gated-SPECT parameters

Article

作者: Pubul Nuñez, V ; Rodríguez Cabalé, E ; Ruibal Morell, Á ; Rodríguez Cabalé, G

BACKGROUNDCoronary artery disease is a complex, multifactorial process with high prevalence and morbidity-mortality. Single photon emission computed tomography (SPECT) myocardial perfusion imaging synchronized with the electrocardiogram (gated-SPECT) is a non-invasive imaging technique that has demonstrated high sensitivity and specificity for diagnosis and staging. To better predict the risk of adverse events, it is necessary to analyze the simultaneous behavior of clinical elements and diagnostic tests, a type of study that is scarce in the current literature. This research evaluated the relationship between clinical characteristics and gated-SPECT myocardial perfusion parameters with progression to cardiac death; subsequently, a model was built to predict the risk of such an outcome.METHODSAn observational, longitudinal, and retrospective study was conducted with 2 230 patients who underwent this test due to suspected coronary artery disease. Clinical characteristics, test parameters, and progression to cardiac death were collected and the relationships between them were studied. A logistic regression model was built to study the relationships between the variables and their influence on the probability of progression to cardiac death.RESULTSClinical characteristics associated with a higher probability of cardiac death were male sex (OR = 5.104, p = 0.004), peripheral arterial disease (OR = 7.175, p < 0.001), and diabetes mellitus (OR = 3.159, p = 0.013). The gated-SPECT parameters associated with a higher risk of this outcome were VTS ≥70 ml (OR = 12.257, p < 0.001), EF < 50% (OR = 10.757, p < 0.001), VTD ≥140 ml (OR = 8.884, p < 0.001), ventricular dilation (OR = 8.959, p < 0.001), and reversible defects (OR = 7.454, p = 0.001). Fixed defects, parietal motility abnormalities, the presence of both reversible and fixed defects, and the hyperdynamic gated state were also associated with a higher risk of cardiac death but with lower ORs. The logistic regression model showed good overall performance and high ability to determine progression to cardiac death, close to perfect predictive capacity (AUC = 0.9656).

2025-03-01·Gut

Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled clinical trial of GETECCU

Article

作者: Ceballos, Daniel ; Torrealba, Leyanira ; Rivero, Montserrat ; Riestra, Sabino ; Navarro-Llavat, Mercè ; Barreiro-de Acosta, Manuel ; Garre, Ana ; Rodríguez-Lago, Iago ; Iborra, Marisa ; Delgado-Guillena, Pedro ; Torrella, Emilio ; Mejuto, Rafael ; Sampedro, Manuela Josefa ; Donday, María G ; Gutiérrez, Ana ; García, María José ; Acosta, Diana ; Esteve, Maria ; Guerra, Iván ; Mañosa, Miriam ; Bosca-Watts, Marta Maia ; García-Alonso, Francisco Javier ; Morales-Alvarado, Víctor J ; García-Sánchez, Valle ; Chaparro, María ; Fernández-Salazar, Luis ; Benítez, José-Manuel ; Busquets, David ; Alonso-Abreu, Inmaculada ; Van Domselaar, Manuel ; Casanova, María José ; Serra Nilsson, Katja ; Navarro, Pablo ; Blázquez, Isabel ; Martín-Arranz, María Dolores ; Merino, Olga ; Nantes Castillejo, Óscar ; Marín Jiménez, Ignacio ; Nos, Pilar ; Muñoz Villafranca, Carmen ; García-Bosch, Orlando ; Baldán, Montse ; Marín Pedrosa, Sandra ; Gisbert, Javier P ; Vicuña Arregui, Miren ; Barrio, Jesús ; Domènech, Eugeni ; Pineda, Juan Ramón ; Batista, Lissette ; de Francisco, Ruth ; Vera Mendoza, Maribel ; Martínez, Concepción ; Bouhmidi, Abdel ; Arias-González, Laura ; Lucendo, Alfredo J ; Núñez-Ortiz, Andrea ; Panés, Julián ; Leo Carnerero, Eduardo

Background and objectivesPrimary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and immunomodulators who withdraw anti-TNF treatment versus those who maintain it. Secondary objectives: to evaluate the effect of anti-TNF withdrawal on relapse-free time, endoscopic and radiological activity, safety, quality of life and work productivity; and to identify predictive factors for relapse.DesignProspective, quadruple-blind, multicentre, randomised, controlled trial. Patients with ulcerative colitis or Crohn’s disease in clinical remission for >6 months and absence of severe endoscopic (and radiological in Crohn’s disease) lesions were randomised to maintain anti-TNF treatment (maintenance arm (MA)) or to withdraw it (withdrawal arm (WA)). All patients maintained immunomodulators. Patients were followed-up until month 12 or up to clinical relapse.ResultsOne-hundred forty patients were randomised: 70 were allocated to the MA and 70 to the WA. The proportion of patients with sustained clinical remission at 12 months was similar in the MA and WA: 59/70 (84%), 95% CI=74% to 92% versus 53/70 (76%), 95% CI=64% to 85%. The proportion of patients with significant endoscopic lesions at the end of follow-up was 8.5% in the MA and 19% in the WA (p=0.1); a higher proportion of patients had faecal calprotectin >250 µg/g at the end of follow-up in the WA (p=0.01). The same percentage of patients in both groups had at least one adverse event (69%). The proportion of patients with serious adverse events was also similar in both groups (4% in MA vs 7% in WA).ConclusionAnti-TNF withdrawal in selected patients with IBD in clinical, endoscopic and radiological remission has no impact on sustained clinical remission at 1 year although objective markers of activity were higher in patients who withdrew treatment.Trial registration number

https://www.clinicaltrialsregister.eu/ctr-search/search?query=2015-001410-10

https://clinicaltrials.gov/study/NCT02994836

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