Synthesis Methods of An HIV Integrase Inhibitor Raltegravir
作者: Zhu Jun
Synthesis methods of Raltegravir were summarized and analyzed, possible industrial production method was suggested.
Huaxue Yu Shengwu Gongcheng
New Synthetic Process of Clobetasol Propionate
作者: Wang Ruiling ; Chen Yuzhen ; Li Hexing ; Wang Haibo
Using DB11 as a staring material, we obtained the intermediate through the three-step reaction of sulfonation-chloro-propionylation by a one-pot method.Then we synthesized Clobetasol propionate with the total yield of 81% and HPLC purity of more than 99% through the reactions of fluorination and refine.The structure of Clobetasol propionate is confirmed by ∼1HNMR and ESI-MS.
Dangdai Huagong Yanjiiu
Application of Brominated Reagents in Chemical Synthesis
作者: Yang Lin ; Qi Dingchao ; Gao Yongliang ; Zhang Shaoping
This paper focuses on the specific application of brominated reaction reagents in chem. synthesis.Brominated reaction reagents can be reasonably used in many fields.Based on this, the elemental brominated reagents and organic brominated reagents are deeply analyzed to ensure the rational utilization of various types of brominated reaction reagents in chem. synthesis.