The objective was to prepare imiquimod cream, a neotype topical immunomodulator for the treatment of condyloma acuminatum.The oil phase was formed by melting benzyl alc., isostearic acid, stearyl alc. etc. with heat, while the water phase was shaped by melting glycerol, methylparaben, propylparaben etc. with heat as well.The cream matrix was wrought by adding the oil phase into the water phase and the imiquimod cream was finished by adding fine powder of imiquimod into the cream matrix.The content of imiquimod in the cream was determined with UV spectrophotometry, and the therapeutic effectiveness of the cream in the treatment of 125 patients with condyloma acuminatum was kept under observation.The preparation technol. of the imiquimod cream was simple and its quality controllable.The overall effective rate of the cream in the 8 wk treatment of 125 cases of condyloma acuminatum was 97.60%.The imiquimod cream was shown to be an effective remedy in the treatment of condyloma acuminatum and may serve as the drug of first choice clin. for combating the disease.