Delving into the Latest Updates on Pharmacia and Upjohn with Synapse

概览

疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

PDE4(磷酸二酯酶4)	1

关联

1

项与 Pharmacia and Upjohn 相关的药物

Crisaborole

克立硼罗

靶点

PDE4

作用机制

PDE4抑制剂

在研机构

Anacor Pharmaceuticals LLC [+6]

原研机构

Anacor Pharmaceuticals LLC

在研适应症

特应性皮炎 [+1]

非在研适应症

斑块状银屑病 [+1]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2016-12-14

100 项与 Pharmacia and Upjohn 相关的临床结果

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0 项与 Pharmacia and Upjohn 相关的专利（医药）

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158

项与 Pharmacia and Upjohn 相关的文献（医药）

2001-09-01·PharmacoEconomics Italian Research Articles

Uno studio retrospettivo condotto presso i medici di medicina generale

作者: Silvia Chiroli ; D. Roggeri

This study aim was to evaluate the resource consumption and costs related to gastrointestinal adverse events of non steroidal anti-inflammatory drugs (NSAIDs) from the perspective of the Italian National Health Service. A retrospective, observational study of 3–6 months’ duration. 51 General Practitioners (GPs) in Italy. Participating GPs were asked to fill up, for at least a three months’ period, a report form describing adverse events in pts. with ostheoarthritis and rheumathoid arthritis treated with NSAIDs. 541 adverse events of different severity were recorded. Costs related to one day therapy per event were the following: 1,54 € for gastro-intestinal event (dyspepsia and abdominal pain), 2,41 € for bleeding without hospitalisation, 21,71 € for bleeding with hospitalisation, 2,73 € for ulcer without hospitalisation, 14,06 € for ulcer with hospitalisation, 60,05 € for ulcer complications. Within each category, costs were higher for hospitalised pts. compared with outpatients. When only non-hospitalised pts. were considered, there were wide cost differences among the four categories of adverse events. Treatment costs due to each adverse event related to NSAIDs are relevant. Hospitalisation is the major driver of cost (more than 78% of the total cost); when hospitalisation is not required, the major driver of cost is drug prescription (more than 52%).

2001-08-01·Biochemistry3区 · 生物学

Thermodynamics of HMGB1 Interaction with Duplex DNA

3区 · 生物学

Article

作者: Knapp, Stefan ; Müller, Susanne ; Bianchi, Marco E.

The high mobility group protein HMGB1 is a small, highly abundant protein that binds to DNA in a non-sequence-specific manner. HMGB1 consists of 2 DNA binding domains, the HMG boxes A and B, followed by a short basic region and a continuous stretch of 30 glutamate or aspartate residues. Isothermal titration calorimetry was used to characterize the binding of HMGB1 to the double-stranded model DNAs poly(dAdT).(dTdA) and poly(dGdC).(dCdG). To elucidate the contribution of the different structural motifs to DNA binding, calorimetric measurements were performed comparing the single boxes A and B, the two boxes plus or minus the basic sequence stretch (AB(bt) and AB), and the full-length HMGB1 protein. Thermodynamically, binding of HMGB1 and all truncated constructs to duplex DNA was characterized by a positive enthalpy change at 15 degrees C. From the slopes of the temperature dependence of the binding enthalpies, heat capacity changes of -0.129 +/- 0.02 and -0.105 +/- 0.05 kcal mol(-1) K(-1) were determined for box A and full-length HMGB1, respectively. Significant differences in the binding characteristics were observed using full-length HMGB1, suggesting an important role for the acid tail in modulating DNA binding. Moreover, full-length HMGB1 binds differently these two DNA templates: binding to poly(dAdT).(dTdA) was cooperative, had a larger apparent binding site size, and proceeded with a much larger unfavorable binding enthalpy than binding to poly(dGdC).(dCdG).

2001-02-01·The Journal of Organic Chemistry2区 · 化学

Synthesis of Homochiral 5- and 8- Substituted 2-[((2-(2,6-Dimethoxyphenoxy)- ethyl)amino)methyl]-1,4-benzodioxanes and Electrophoretic Determination of Their Enantiomeric Excess

2区 · 化学

Article

作者: Pezzetta, Daniele ; Pallavicini, Marco ; Villa, Luigi ; Valoti, Ermanno

The title compounds (I; R = OMe, R¹ = H; R = H, R¹ = OMe, F) were prepared starting from enantiomers of glycerol acetonide tosyl ester and using 2,6- or 2,3-disubstituted phenols as building blocks.Enantiomeric excesses were determined by cyclodextrin-modified capillary electrophoresis.

100 项与 Pharmacia and Upjohn 相关的药物交易

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100 项与 Pharmacia and Upjohn 相关的转化医学

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