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疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

化学药	1

排名前五的靶点	数量

EGFR(表皮生长因子受体erbB1)	1

关联

1

项与 Universidade Federal do Ceará 相关的药物

LASSBio-1920

靶点

EGFR

作用机制

EGFR调节剂

在研机构

Universidade Federal do Ceará

原研机构

Universidade Federal do Ceará

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

122

项与 Universidade Federal do Ceará 相关的临床试验

RBR-10xsbmmb / Not yet recruitingN/AIIT

Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation - TECLI Telehealth in Chronic nonspecific Low back pain

开始日期2025-08-21

申办/合作机构

Universidade Federal dos Vales do Jequitinhonha e Mucuri

[+1]

RBR-2sgn9cy / Not yet recruitingN/AIIT

Effectiveness of Wise Infant Development® software in the acquisition of knowledge about infant development among nursing students: a randomized controlled clinical trial

开始日期2025-02-01

申办/合作机构

Universidade Federal do Ceará

[+1]

RBR-10k3srtd / Not yet recruitingN/AIIT

Effectiveness of Educational Technology to Prevent Falls in the hospital: randomized clinical trial

开始日期2025-01-01

申办/合作机构

Universidade Federal do Ceará

[+1]

100 项与 Universidade Federal do Ceará 相关的临床结果

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0 项与 Universidade Federal do Ceará 相关的专利（医药）

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39,170

项与 Universidade Federal do Ceará 相关的文献（医药）

2025-01-01·Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Structural insights and antimicrobial synergy of a proto-galectin from the marine sponge Aiolochroia crassa

Article

作者: Vasconcelos, Mayron Alves de ; de Sousa, Bruno Lopes ; Teixeira, Edson Holanda ; Pinheiro, Ulisses ; Nascimento, Elielton ; Sampaio, Alexandre Holanda ; Andrade, Alexandre Lopes ; Nagano, Celso Shiniti ; Costa Filho, Manoel Ferreira da ; Torres, Renato Cezar Farias ; Júnior, Israel Ferreira Barbosa ; Carneiro, Rômulo Farias ; Duarte, Jéssica de Assis ; Malveira, Ellen Araujo ; Souza, Victoria Régia Pinto de ; Chaves, Renata Pinheiro

In this study, we isolated a novel lectin from the marine sponge Aiolochroia crassa, named AcrL. The lectin showed a preference for glycans containing sialic acid terminal residues, as indicated by the strongest inhibition with fetuin and bovine submaxillary mucin. Primary structure determination by mass spectrometry revealed that AcrL is a galectin with conserved amino acid residues typically involved in carbohydrate binding. Structural modeling indicated that AcrL adopts a typical galectin β-sandwich motif, featuring two anti-parallel β-sheets with five strands each. Docking calculations revealed a carbohydrate-binding site composed of a main site, capable of hosting galactopyranosides, and an extended site, facilitating the binding of complex carbohydrates. AcrL inhibited significant biofilm formation against Staphylococcus aureus, S. epidermidis, and Escherichia coli with concentrations ranging from 500 to 15.6 μg.mL^-1 for S. aureus, 7.8 μg.mL^-1 for S. epidermidis, and 500 μg.mL^-1 for E. coli. Furthermore, when combined with different antibiotics, AcrL potentiated their effect against pathogenic bacteria. The antimicrobial mechanism of AcrL was investigated using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The analysis indicates that AcrL induces damage to the bacterial membrane. These findings underscore the discovery of a novel galectin in a basal organism and the comprehensive biochemical characterization conducted in this research, highlighting the potential of AcrL as a novel antibacterial agent and emphasizing its importance in combating bacterial infections.

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Dynamics of magnetic inhomogeneity in La2CoMnO6 films probed by Raman spectroscopy

Article

作者: W A Paschoal, C ; Silva, A V S ; Nonato, A. ; Silva, R.X. ; W. A. Paschoal, C. ; Silva, R X ; Silva, A.V.S. ; Paschoal, A R ; Paschoal, A.R. ; Nonato, A

We report the dynamic effects of magnetic inhomogeneity on the temperature evolution of the Raman modes in polycrystalline La₂CoMnO₆ (LCMO) films. The LCMO films were obtained via chemical solution deposition and annealed at different temperatures, 700, 800 and 900 °C. Temperature-dependent Raman spectroscopic studies uncover anomalous phonon energy behaviors, associated with strong spin-phonon couplings revealed even at ambient conditions. This effect, which is observed to occur well above ferromagnetic ordering temperature is ascribed to short-range Mn⁴⁺/Co²⁺ ferromagnetic clusters. Moreover, our study has shown that spin-phonon coupling strength is governed by competing antiferromagnetic (AFM) and ferromagnetic (FM) interactions. These results significantly enhance the understanding of the complex spin-phonon coupling mechanism to provide insights into magnetic inhomogeneity in systems with two or more magnetic sublattices. These findings suggest the presence of similar effects in other double perovskites within the RE₂CoMnO₆ (RE = rare earths) family, which exhibit analogous magnetic sublattice and order-disorder defects.

2025-01-01·Fluid Phase Equilibria

Fluid Phase Equilibria Carbon Dioxide + Decane + Hexadecane Ternary System

作者: Medeiros, Hugo Andersson Dantas ; Vera, Willam Trujillo ; da Costa, Moacir Frutuoso Leal ; de Sant′Ana, Hosiberto Batista ; Soria, Evelyn Claudia Quinteros ; Feitosa, Filipe Xavier ; de Sant'Ana, Hosiberto Batista

The interest in understanding reservoir fluids′ phase behavior is to increase hydrocarbon production without any flow assurance issues.Due to its opacity, the evident complexity of determining phase equilibrium data revolves around the thermodn. modeling of model systems.The article presents exptl. phase equilibrium data and thermodn. modeling for the CO₂ + decane + hexadecane ternary system at 283.15, 298.15, and 323.15 K and pressures up to 20 MPa.The transitions observed during this study were liquid-liquid (LL), vapor-liquid (VL), and vapor-liquid-liquid (VLL).The Peng-Robinson equation of state was used to model this ternary system for various compositionsThe temperature-dependent binary interaction parameters (k_ij) for the CO₂ + n-alkane mixtures were adjusted to the exptl. data.Addnl., a binary interaction parameter for the n-C₁₆H₃₄/n-C₁₀H₂₂ pair, independent of temperature, was obtained through the critical volume of the components.The results reveal complex behaviors as the mixture′s composition of hexadecane progressively increases.Adding this longer-chain linear hydrocarbon influences the phase behavior, leading to the emergence of liquid-liquid transitions and barotropic inversion in the system.This study contributes valuable data on model systems representing crude oil, highlighting complex behaviors in ternary systems with high carbon dioxide content.

100 项与 Universidade Federal do Ceará 相关的药物交易

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100 项与 Universidade Federal do Ceará 相关的转化医学

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