Delving into the Latest Updates on 南京康海药业有限公司 with Synapse

概览

疾病领域	数量

血液及淋巴系统疾病	1
免疫系统疾病	1
神经系统疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

PSMA(前列腺癌特异性膜抗原)	1

关联

1

项与南京康海药业有限公司相关的药物

Vincristine Sulfate

硫酸长春新碱

靶点

PSMA

作用机制

PSMA抑制剂

在研机构

Eli Lilly Japan KK [+4]

原研机构

Eli Lilly & Co.

在研适应症

嗜铬细胞瘤 [+9]

非在研适应症

成人急性淋巴细胞白血病 [+43]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1963-07-10

3

项与南京康海药业有限公司相关的临床试验

CTR20131194

/ Completed临床1期

注射用硫酸长春新碱脂质体单次人体耐受性及药代动力学试验

确定注射用硫酸长春新碱脂质体单次给药临床最大耐受剂量(MTD)和剂量限制性毒性(DLT)；获得单次给药人体药代动力学参数；获得与注射用硫酸长春新碱的药代对比参数。

开始日期-

申办/合作机构

南京绿叶制药有限公司

[+1]

CTR20131092

/ Recruiting临床3期

注射用硫酸长春新碱脂质体联合的化疗方案治疗成人急性淋巴细胞白血病的有效性及安全性的Ⅲ期临床研究

1. 主要目的：进一步评价注射用硫酸长春新碱脂质体治疗急性淋巴细胞白血病的疗效和外周神经毒性发生率。 2. 次要目的：进一步评价注射用硫酸长春新碱脂质体治疗急性淋巴细胞白血病的安全性。

开始日期2013-06-07

申办/合作机构

南京绿叶制药有限公司

[+1]

CTR20131124

/ Completed临床2期

注射用硫酸长春新碱脂质体联合的化疗方案治疗成人急性淋巴细胞白血病的安全性及有效性研究

1. 主要目的：初步评价注射用硫酸长春新碱脂质体治疗急性淋巴细胞白血病的安全性。 2. 次要目的：：初步评价注射用硫酸长春新碱脂质体治疗急性淋巴细胞白血病的有效性；为注射用硫酸长春新碱脂质体的IIb/III期临床研究提供依据。

开始日期2010-12-03

申办/合作机构

南京绿叶制药有限公司

[+1]

100 项与南京康海药业有限公司相关的临床结果

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0 项与南京康海药业有限公司相关的专利（医药）

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2

项与南京康海药业有限公司相关的文献（医药）

2006-01-01·Biological and Pharmaceutical Bulletin4区 · 医学

Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model

4区 · 医学

Article

作者: Pan, Ying ; Zhang, Wei-Yun ; Kong, Ling-Dong ; Xia, Xing ; Cheng, Guang

The ethanolic extracts from the rhizome of Curcuma longa L. (turmeric), possesses a wide variety of biological activities related to the treatment and prevention of affective disorders. To study their antidepressant effects, the impacts of chronic mild stress (CMS) and of the subsequent administration of ethanolic extracts of C. longa were investigated. Male Sprague-Dawley rats subjected to the CMS procedure demonstrated increased serum interleukin-6 and tumor necrosis factor-alpha levels, as well as a reduction of natural killer cell activity in splenocytes. In addition, CMS-treated rats exhibited elevated corticotropin-releasing factor in serum and medulla oblongata and cortisol levels in serum, with no significant change in serum adrenocorticotropin hormone levels. The preferential behavior of reduction in sucrose intake was also observed. These findings indicate that the alterations in immune and hypothalamic-pituitary-adrenal (HPA) axis systems could participate in the behavioral response to the CMS procedure in animals. Administration of ethanolic extracts of C. longa largely reversed the above effects. These results demonstrate the antidepressant-like activity of ethanolic extracts of C. longa in the rat CMS model of depression, at least in part by improving the abnormalities in immune and the HPA axis functions.

Shengwu Jiagong Guocheng

Determination of dextroisomer in selegiline hydrochloride by HPLC

作者: Zhang, Guo-xi ; Zhou, Xin-wei

To establish an HPLC method for the detection of optical isomer in selegiline hydrochloride, the chromatog. conditions including column, mobile phase and detection wavelength were optimized.The linearity, precision, recovery, detectability and stability of sample solution were investigated.The results indicated that under the optimized conditions (cyclohexane and isopropanol (99.8:0.2) as mobile phase, flow rate 1 mL/min^-1 and temperature 10-30°), R and S-selegiline hydrochloride could be separated effectively.The proposed method could be applied to detect the dextroisomer in selegiline hydrochloride.

100 项与南京康海药业有限公司相关的药物交易

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100 项与南京康海药业有限公司相关的转化医学

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