Delving into the Latest Updates on Opocrin SpA with Synapse

In patients with moderate dry eye syndrome is a three months treatment with with arabinogalactan monodose ophthalmic formulation 5% as safe and effective as hyaluronic acid 0.2% for the control of subjective and objective symptoms of dry eye?

开始日期2009-12-16

申办/合作机构

Opocrin SpA

100 项与 Opocrin SpA 相关的临床结果

登录后查看更多信息

0 项与 Opocrin SpA 相关的专利（医药）

登录后查看更多信息

1

项与 Opocrin SpA 相关的文献（医药）

2018-07-01·Journal of Pharmaceutical and Biomedical Analysis3区 · 医学

Fine structural characterization of sulodexide

3区 · 医学

Article

作者: Urso, Elena ; Veraldi, Noemi ; Guerrini, Marco ; Bisio, Antonella ; Bertini, Sabrina ; Bensi, Donata ; Risi, Giulia

Sulodexide is a heparinoid which combines the properties of its components heparin and dermatan sulfate and is used not only for the prophylaxis and treatment of thromboembolic diseases but also for the treatment of diabetic nephropathy. Despite many clinical studies have been conducted to investigate its activity and safety, no data are available on the fine chemical characterization of its components. In this work, the in-depth investigation on the structural features of both the whole mixture and the isolated components was accomplished, involving the analysis of molecular weight distribution and of their mono, di and oligosaccharide composition by HP-SEC/TDA, 2D-NMR and HPLC-MS techniques. Moreover, also the separation of fractions endowed of graded affinity to antithrombin was achieved followed again by detailed structural analysis. The combination of different techniques permits to profile in depth the structural features of such a drug and offers a useful tool for possible analysis of batch production.

100 项与 Opocrin SpA 相关的药物交易

登录后查看更多信息

100 项与 Opocrin SpA 相关的转化医学

登录后查看更多信息