An International, Partially-randomised, Patient-preference Trial Within a Registry of High Versus Lower Intensity Radiological Surveillance Following Primary Resection of Retroperitoneal, Abdominal and Pelvic Soft Tissue Sarcoma

The SARveillance trial is an efficient, pragmatic, multi-centre, international, stratified, partially-randomised, patient-preference trial within a registry of high versus lower intensity radiological surveillance following primary resection of retroperitoneal, abdominal and pelvic soft tissue sarcoma. The trial design is stratified by sarcoma tumour grade (high/intermediate grade and low grade).

开始日期2024-11-01

申办/合作机构

Fondazione Irccs Istituto Nazionale Dei Tumori

[+18]

NCT06655272 / Not yet recruiting临床4期IIT

OM 85 to Prevent Respiratory Infections in Older At Risk Patients

People living in NH are at higher risk of respiratory infections compared to their counterpart living in the community. Products obtained from dead bacteria ("bacterial lysate") can be used to boost immune system and may reduce the risk of respiratory infections. Very little information is available on the effect of these substances in older people. This study will evaluate the efficacy of a bacterial lysate in reducing the incidence of lower respiratory tract infections in older people living in nursing homes. The study will include a treatment arm, in which participants will received the lysate, and a control arm in which participants will received a matching placebo (i.e., a pill that has the same appearance of the lysate but does not contain the lysate itself).

开始日期2024-11-01

申办/合作机构

Università Campus Bio-Medico di Roma

[+1]

NCT06178952 / RecruitingN/AIIT

Transcranial Pulse Stimulation (TPS) in Post-COVID-19

The objective of the present study is to demonstrate treatment efficacy of transcranial pulse stimulation for patients with Post-COVID-19 related neurological symptoms (fatigue, cognitive deficits, mood deterioration). Fatigue, as measured by the Fatigue Impact Scale (FIS), will represent the primary outcome variable. The verum treatment will be compared to a sham (placebo) condition.

开始日期2024-01-08

申办/合作机构

Medical University of Vienna

[+1]

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5,452

项与 Università Campus Bio-Medico di Roma 相关的文献（医药）

2024-12-01·Stem Cell Research

Induced pluripotent stem cell production (CSSi019-A)(14432) from an asymptomatic subject carrying a expansion of C9orf72 gene

Article

作者: Consalez, G ; Sabatelli, M ; Codazzi, F ; Vescovi, A ; Marano, M ; Vulcano, E ; Lattante, S ; D'Anzi, A ; D'Asdia, C ; Di Lazzaro, V ; Pennuto, M ; Ferrari, D ; Ruotolo, G ; Rosati, J ; Giovenale, A M G ; Giacometti, C

One of the genetic mutations most associated with the onset of amyotrophic lateral sclerosis, both in sporadic and familial cases, is the expansion of the C9orf72 gene. The presence of more than 30 repeats (GGGGCC) correlates with uncertain ALS symptomatology. Here we collected a dermal biopsy from a subject carrying 36 hexanucleotide repeats and reprogrammed it into an induced pluripotent stem cell line. Despite the number of repeat elements, the subject had no symptoms at the age of the biopsy (76 years), thus resulting in a healthy carrier of the mutation.

2024-11-01·NEUROLOGICAL SCIENCES

Blood pressure monitoring in elderly migraineurs starting an anti-CGRP monoclonal antibody: a real-world prospective study

Article

作者: Andrini, Giorgia ; Mascarella, Davide ; Favoni, Valentina ; Vernieri, Fabrizio ; Guerzoni, Simona ; Cevoli, Sabina ; Pierangeli, Giulia ; Altamura, Claudia ; Lo Castro, Flavia ; Baraldi, Carlo

Abstract:

Background:

While monoclonal antibodies (mAbs) targeting the CGRP pathway have revolutionized migraine management due to their improved tolerance and adherence, concerns remain about their potential impact on blood pressure (BP), especially in older patients, due to CGRP-mediated vasodilation blockade. Given the growing use of these therapies in older populations, assessing their cardiovascular (CV) safety is of paramount importance.

Methods:

This multicentric observational prospective study focused on migraine sufferers aged ≥ 60 who began erenumab, galcanezumab, or fremanezumab for prevention. Baseline, three-month, and twelve-month BP measurements were collected. Changes in antihypertensive medication and "Newly or Worsened Hypertensive" patients (NWHP) were assessed.

Results:

Among 155 patients receiving anti-CGRP mAbs (40 Erenumab, 47 Galcanezumab, 68 Fremanezumab), 42.5% had hypertension history and 39% were on antihypertensive treatment. No significant systolic or diastolic BP changes occurred at any time point compared to baseline (all p > 0.05), with no differences between the three groups. After one year, 20/155 (12.9%) patients were considered NWHP; 11/20 had prior hypertension, and 5/11 adjusted antihypertensive therapy. Among 9/20 newly hypertensive patients, 5/9 had a single measurement above the normal threshold with no requirement for new pharmacological therapy. A higher baseline BP value was associated with increased BP (p = 0.002).

Conclusions:

The study concludes that treatment with anti-CGRP mAbs over one year does not significantly affect BP in patients aged ≥ 60, nor does it increase the incidence of hypertension compared to general population trends. Nonetheless, continuous monitoring and further long-term studies are necessary to fullya scertain the cardiovascular safety of these medications in the elderly.

2024-11-01·Academic radiology

Posterior Subcutaneous Edema at Lumbar Spine MRI: A Systematic Review

Review

作者: Bernetti, Caterina ; Stiffi, Massimo ; Mallio, Carlo A ; Beomonte Zobel, Bruno ; Quattrocchi, Carlo C ; Parizel, Paul M ; Mancuso, Valeria ; Volterrani, Claudia ; Van Goethem, Johan ; Greco, Federico

RATIONALE AND OBJECTIVES:

Edema in the subcutaneous soft tissue of the lumbar spine is a frequent incidental finding in spinal magnetic resonance imaging, however, its exact explanation is yet to be determined. The aim of this paper is to provide a systematic literature review on posterior lumbar subcutaneous edema (LSE).

MATERIALS AND METHODS:

The present systematic literature search was carried out in October 2023 using electronic databases: PubMed, Cochrane library, and Scopus.

RESULTS:

The current evidence suggests that lumbar edema is correlated with clinical data such as weight and age, and potentially female sex. Moreover, LSE is related to several specific conditions, including both systemic and spinal disorders, such as heart or kidney disorders, as well as low back pain and degenerative and/or inflammatory diseases.

CONCLUSION:

It is important to be aware that there is an association between LSE and a variety systemic and spinal disorders.

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