Delving into the Latest Updates on University of Puerto Rico-RÃ­o Piedras with Synapse

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疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

CDC42(细胞分裂周期蛋白42)	1

关联

1

项与 University of Puerto Rico-RÃo Piedras 相关的药物

MBQ-167

靶点

CDC42

作用机制

CDC42 抑制剂

在研机构

University of Puerto Rico-RÃo Piedras [+1]

原研机构

University of Puerto Rico-RÃo Piedras

在研适应症

晚期乳腺癌 [+1]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

100 项与 University of Puerto Rico-RÃo Piedras 相关的临床结果

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0 项与 University of Puerto Rico-RÃo Piedras 相关的专利（医药）

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3,135

项与 University of Puerto Rico-RÃo Piedras 相关的文献（医药）

2024-10-01·Medicine & Science in Sports & Exercise

German And Spanish Adaptations Of The Crave Scale For Motivation States For Physical Activity

作者: Amador, Anamaria ; Aponte, Lisa ; Reichert, Dominic ; Casper, Regina ; Malcolm, Lydia ; Stults-Kolehmainen, Matthew ; Vogelsang, Anna ; Olfermann, Robin ; Reichert, Markus ; Filgueiras, Alberto ; Blacutt, Miguel ; Estrella, Carla ; Nigg, Claudio R. ; Hernández-Torres, Emmanuel ; Perez, Amanda ; Alvarez, Lery ; Rehder, Johanna ; Boullosa, Daniel A. ; Herrero-Molleda, Alba ; Abolt, Charles ; Gil-Calvo, Marina

2024-09-03·Proceedings of the National Academy of Sciences

A long noncoding RNA at the cortex locus controls adaptive coloration in butterflies

Article

作者: van der Heijden, Eva S. M. ; Papa, Riccardo ; Kamrava, Kiana ; Carter, Alexander ; Evans, Elizabeth ; Mazo-Vargas, Anyi ; Jiggins, Chris D. ; Wright, Charlotte J. ; Loh, Ling S. ; Livraghi, Luca ; Hanly, Joseph J. ; Martin, Arnaud ; Reed, Robert D.

Evolutionary variation in the wing pigmentation of butterflies and moths offers striking examples of adaptation by crypsis and mimicry. The cortex locus has been independently mapped as the locus controlling color polymorphisms in 15 lepidopteran species, suggesting that it acts as a genomic hotspot for the diversification of wing patterns, but functional validation through protein-coding knockouts has proven difficult to obtain. Our study unveils the role of a long noncoding RNA (lncRNA) which we name ivory , transcribed from the cortex locus, in modulating color patterning in butterflies. Strikingly, ivory expression prefigures most melanic patterns during pupal development, suggesting an early developmental role in specifying scale identity. To test this, we generated CRISPR mosaic knock-outs in five nymphalid butterfly species and show that ivory mutagenesis yields transformations of dark pigmented scales into white or light-colored scales. Genotyping of Vanessa cardui germline mutants associates these phenotypes to small on-target deletions at the conserved first exon of ivory . In contrast, cortex germline mutant butterflies with confirmed null alleles lack any wing phenotype and exclude a color patterning role for this adjacent gene. Overall, these results show that a lncRNA gene acts as a master switch of color pattern specification and played key roles in the adaptive diversification of wing patterns in butterflies.

2024-09-01·Puerto Rico health sciences journal

A Bayesian Projection of the Total Fertility Rate of Puerto Rico: 2020-2050.

Article

作者: Mattei, Hernando ; Rosario-Santos, Angélica M ; Pericchi-Guerra, Luis

OBJECTIVEThe abrupt decline in the Total Fertility Rate (TFR) of Puerto Rico to 0.9 children per woman, well below the replacement level of 2.1 children per woman, makes the prospect of a sustained population decline a real possibility. Population projections produced by the United States Census Bureau and the United Nations Population Division show that the island population may decline from 3.8 millions in 2000 to slightly above 2 million by 2050, a dramatic population decline of 47% in 50 years. Both population projections assume that all countries with a TFR below replacement level could eventually increase toward or oscillate to 2.1 children per woman and have Puerto Rico's TFR approaching 1.5 by 2050. This assumption has been widely criticized as unrealistic and not supported by evidence. The main objective of our research is to provide an alternative fertility projection for Puerto Rico by 2050 that has more realistic assumptions.METHODSOur methodology is based on the Bayesian Hierarchical Probabilistic Theory used by the United Nations to incorporate a way to measure the uncertainty and to estimate the projection parameters. We modified the assumptions used by the United Nations by considering 17 countries with TFR similar to Puerto Rico.RESULTSBy 2050, Puerto Rico may have a TFR of 1.1 bounded by a 95% credibility interval (0.56,1.77).CONCLUSIONUnder this scenario Puerto Rico can expect to have a larger population decline than that projected by the Census Bureau and the United Nations.

100 项与 University of Puerto Rico-RÃo Piedras 相关的药物交易

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100 项与 University of Puerto Rico-RÃo Piedras 相关的转化医学

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