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疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与 Aprogen Biologics, Inc. 相关的药物

Azelaic Acid

壬二酸

靶点-

作用机制-

在研机构

Leo Pharma, Inc. [+5]

原研机构

Allergan Ltd. (Ireland)

在研适应症

丘疹性荨麻疹 [+3]

非在研适应症

口周皮炎

最高研发阶段批准上市

首次获批国家/地区

韩国

首次获批日期1994-02-17

100 项与 Aprogen Biologics, Inc. 相关的临床结果

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0 项与 Aprogen Biologics, Inc. 相关的专利（医药）

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1

项与 Aprogen Biologics, Inc. 相关的文献（医药）

2019-01-01·Journal of Hard Tissue Biology

Synergistic Effect of Tolerogenic Dendritic Cells and Etanercept on a Collagen-induced Arthritis Animal Model

作者: Cho, Kil-Sang ; Jung, Sang Youn ; Byun, Sei-Hee ; Jang, Jin-ah ; Park, Soo-Yeoun ; Choi, Jinjung ; Park, Jun-Eui ; Lim, Dae-Seog ; Jung, Nam-Chul ; Choi, So-Yeon ; Jang, Doo-Rye ; Chung, Kwang-Hoe ; Lee, Jun-Ho ; Lee, Hyun Soo

The aim of this study was to determine the potential for an additive effect from combining treatments with tolerogenic dendritic cells (tDCs) and etanercept (ETN) in a case of established type II collagen-induced arthritis (CIA).CIA mice were treated with type II collagen-pulsed tDCs either alone or in combination with ETN.We compared the effects of monotherapy with tDCs or ETN with the effect of combination treatment on the resultant rheumatoid arthritis using histopathol. analyzes and measurements of paw volumes, regulatory T cell populations, and cytokine levels.The clin. and histol. anal. revealed an additive effect from the combination therapy.Monotherapy with tDCs showed a tendency to ameliorate arthritis symptoms, while monotherapy with ETN reduced the paw swelling at 3 days after administration, but was not effective toward the end of the exptl. period.The combined treatment group also showed a marked inducement of the regulatory T cells and Th2 cytokines that are affected by tDCs compared with those of either untreated or ETN-treated CIA mice.ETN administered in combination with tDCs provided a substantially higher level of clin. benefit at the cellular level to CIA mice than the administration of either of these agents alone.

100 项与 Aprogen Biologics, Inc. 相关的药物交易

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100 项与 Aprogen Biologics, Inc. 相关的转化医学

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