A randomized, double-blind, placebo-controlled, dose-finding, multicenter phase II clinical study on the efficacy and safety of Lianhua Yuping Granules in the treatment of common cold with qi deficiency syndrome
Epiberberine, a natural bioactive protoberberine alkaloid, was totally synthesized in short, convenient and low-cost, four-step reactions including cyclization, condensation, reduction, and ring-closing, with an overall yield of 26.1%.