更新于：2024-11-01

CD300A x IgE

更新于：2024-11-01

基本信息

关联

项与 CD300A x IgE 相关的药物

BL-9010

靶点

CD300A x IgE

作用机制

CD300A抑制剂 [+1]

在研机构-

原研机构

The Hebrew University of Jerusalem

在研适应症-

非在研适应症

免疫系统疾病

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 CD300A x IgE 相关的临床结果

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100 项与 CD300A x IgE 相关的转化医学

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0 项与 CD300A x IgE 相关的专利（医药）

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项与 CD300A x IgE 相关的文献（医药）

2018-11-15·The Journal of Immunology2区 · 医学

Leukocyte CD300a Contributes to the Resolution of Murine Allergic Inflammation

2区 · 医学

Article

作者: Cohen-Mor, Shahar ; Singh Gangwar, Roopesh ; Puzzovio, Pier Giorgio ; Levi-Schaffer, Francesca ; Levy, Bruce D. ; Shamri, Revital ; Karra, Laila

AbstractCD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined. In this study, employing a mouse model of allergic peritonitis, we demonstrate that CD300a expression on peritoneal cells is regulated from inflammation to resolution. Allergic peritonitis–induced CD300a−/− mice had a rapid increase in their inflammatory cell infiltrates and tryptase content in the peritoneal cavity compared with wild type, and their resolution process was significantly delayed. CD300a−/− mice expressed lower levels of ALX/FPR2 receptor on peritoneal cells and had higher levels of LXA4 in the peritoneal lavage. CD300a activation on mouse bone marrow–derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. Together, these findings indicate a role for CD300a in AI and its resolution, in part via the specialized proresolving mediator LXA4 and ALX/FPR2 receptor pathway activation.

2014-09-01·Journal of Allergy and Clinical Immunology1区 · 医学

Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a

1区 · 医学

Letter

作者: Shibuya, Akira ; Ebo, Didier G ; Bridts, Chris H ; Falcone, Franco H ; De Clerck, Luc S ; Shubber, Saif ; Boita, Monica ; Sabato, Vito

This article studies the effect of phosphatidylserine (PS) recognition by CD300a on IgE/FcεRI-dependent basophilic activation.The apoptosis-related signal PS suppresses human basophil anaphylactic degranulation through the inhibitory receptor CD300a (IRp60).

2012-05-01·Cytometry Part B: Clinical Cytometry4区 · 医学

CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI‐dependent anaphylactic degranulation

4区 · 医学

Article

作者: Bernhard F. Gibbs ; Francesca Levi-Schaffer ; Chris H. Bridts ; Vito Sabato ; Didier G. Ebo ; Marjoke M. Verweij ; Domenico Schiavino ; Luc S. De Clerck

AbstractBackground.The final response that leads to basophil degranulation results from a cross‐talk between activatory and inhibitory signals. However, in the context of basophil biology, the inhibitory mechanisms that control these processes are still poorly understood.Aim.To investigate the expression and function of the inhibitory receptor CD300a in human basophils.Methods.Peripheral blood of 20 patients with birch pollen allergy and 10 healthy control individuals were assessed for CD300a expression before and after activation. To study the function of CD300a, basophils were pre‐incubated with anti‐human CD300a/c monoclonal antibodies and analyzed for the up‐regulation of the activation marker CD203c and appearance of the degranulation marker CD63 following IgE‐dependent and IgE‐independent triggering.Results.Basophils from allergic individuals constitutively expressed significantly less CD300a than non‐allergics (P = 0.001). However, after cross‐linking with either anti‐IgE or recombinant major birch pollen allergen (rBet v 1), basophils from allergic patients demonstrated a significant and rapid (3 min) up‐regulation of CD300a expression in all activated basophils that persisted for over 2 h (P < 0.05). Moreover, CD300a expression was significantly higher in the CD203cbright+CD63bright+ subpopulation than in CD203cbright+CD63− cells (P < 0.05). In both patients and controls, pre‐incubation with anti‐CD300a/c significantly inhibited IgE‐mediated CD63 expression (P < 0.05), though it did not affect CD203c. In contrast, IgE‐independent basophil activation was not inhibited by CD300a/c engagement.Conclusion.CD300a is expressed on human peripheral blood basophils and rapidly up‐regulated upon cross‐linking of IgE/FcεRI and suppresses anaphylactic degranulation. © 2011 International Clinical Cytometry Society