更新于：2024-09-19

HOXD9

更新于：2024-09-19

基本信息

别名

homeobox D9、Homeobox protein Hox-4C、Homeobox protein Hox-5.2

+ [4]

简介

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

关联

100 项与 HOXD9 相关的临床结果

登录后查看更多信息

100 项与 HOXD9 相关的转化医学

登录后查看更多信息

0 项与 HOXD9 相关的专利（医药）

登录后查看更多信息

146

项与 HOXD9 相关的文献（医药）

2024-07-31·Bioscience Reports

Retraction: MiR-205 suppresses epithelial-mesenchymal transition and inhibits tumor growth of human glioma through downregulation of HOXD9

2024-04-01·Advanced Biology

A Glance into the Destiny of Transcriptomic Activity, Embodied by the HOX Genes, in Neonatal and Aging Dermal Cells

Article

作者: Ko, Doyeong ; Kang, Seunghyun ; Kim, Misun ; Mun, Seyoung ; Han, Kyudong ; Nho, Youn-Hwa ; Lee, Dong-Geol ; Kim, Minji

AbstractSkin is an organ having a crucial role in the protection of muscle, bone, and internal organs and undergoing continuous self‐renewal and aged. The growing interest in the prevention of skin aging and rejuvenation has sparked a surge of industrial and research studies focusing on the biological and transcriptional changes that occur during skin development and aging. In this study, the aim is to identify transcriptional differences between two main types of human skin cells: the human dermal fibroblasts (HDFs) and the human epidermis keratinocytes (HEKs) isolated from 30 neonatal and 30 adults (old) skin. Through differentially expressed gene (DEG) profiling using DEseq2, 604 up‐, and 769 down‐regulated genes are identified in the old group. A functional analysis using Metascape Gene Ontology and Reactome pathways revealed systematic transcriptomic shifts in key skin formation and maintenance markers, alongside a distinct difference in HOX gene families crucial for embryonic development and diverse biological processes. Among the 39 human HOX gene family, ten posterior HOX genes (HOXA10, 11, 13, HOXB13, HOXC11, and HOXD9‐13) are significantly downregulated, and anterior 25 genes (HOXA2‐7, HOXB1‐9, HOXC4‐6 and 8–9, and HOXD1,3,4 and 8) are upregulated, especially in the old HDFs. The study successfully demonstrates the correlation between HOX genes and the skin aging process, providing strong evidence that HOX genes are proposed as a new marker for skin aging assessment.

2024-04-01·Molecular Carcinogenesis

BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1

Article

作者: Lin, Zhizhao ; Tang, Weimei ; Yu, Zhen ; Zhang, Hui ; Lin, Jianjiao ; Zhang, Luyu ; Wei, Xiangyang ; Xiang, Li ; Yang, Juanying ; Yang, Ping ; Zhang, Jieming ; Jiang, Ping ; Li, Jiaying ; Wu, Xiaosheng ; Hong, Linjie ; Pei, Miaomiao ; Xiao, Wushuang ; Wang, Jide ; Zhao, Yingying ; Peng, Ying

AbstractGastric cancer (GC) constitutes substantial cancer mortality worldwide. Several cancer types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9). BST2 was significantly upregulated in GC tissues and promoted epithelial–mesenchymal transition and metastasis of GC. BST2 knockdown reversed HOXD9's oncogenic effect on GC metastasis. Moreover, BST2 messenger RNA stability could be enhanced by poly(A) binding protein cytoplasmic 1 (PABPC1) through the interaction between BST2 3′‐UTR and PABPC1 in GC cells. PABPC1 promoted GC metastasis, which BST2 silencing attenuated in vitro and in vivo. In addition, positive correlations among HOXD9, BST2, and PABPC1 were established in clinical samples. Taken together, increased expression of BST2 induced by HOXD9 synergizing with PABPC1 promoted GC cell migration and invasion capacity.