This is a multi-center, open-label Phase 2 study designed to evaluate the efficacy and safety of BA3021 as monotherapy and combination therapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

开始日期2022-12-13

申办/合作机构

BioAtla, Inc.

NCT04918186 / Recruiting临床2期IIT

An Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer

This study is being done to answer the following question: What are the effects of a new drug or drugs on ovarian cancer? The pre-study screening may be done to test a sample of tissue for biomarkers to determine participation in the study.

开始日期2022-05-03

申办/合作机构

Canadian Cancer Trials Group

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100 项与 ROR2 x Tubulin 相关的临床结果

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100 项与 ROR2 x Tubulin 相关的转化医学

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0 项与 ROR2 x Tubulin 相关的专利（医药）

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项与 ROR2 x Tubulin 相关的文献（医药）

2011-12-15·Development2区 · 生物学

Neural crest specification by noncanonical Wnt signaling and PAR-1

2区 · 生物学

Article

作者: Sokol, Sergei Y. ; Ossipova, Olga

Neural crest (NC) cells are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal transition and migrate to diverse locations in vertebrate embryos to give rise to many cell types. Multiple signaling factors, including Wnt proteins, operate during early embryonic development to induce the NC cell fate. Whereas the requirement for the Wnt/β-catenin pathway in NC specification has been well established, a similar role for Wnt proteins that do not stabilize β-catenin has remained unclear. Our gain- and loss-of-function experiments implicate Wnt11-like proteins in NC specification in Xenopus embryos. In support of this conclusion, modulation of β-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premigratory NC. Morpholino-mediated depletion experiments suggest that Wnt11R, a Wnt protein that is expressed in neuroectoderm adjacent to the NC territory, is required for NC formation. Wnt11-like signals might specify NC by altering the localization and activity of the serine/threonine polarity kinase PAR-1 (also known as microtubule-associated regulatory kinase or MARK), which itself plays an essential role in NC formation. Consistent with this model, PAR-1 RNA rescues NC markers in embryos in which noncanonical Wnt signaling has been blocked. These experiments identify novel roles for Wnt11R and PAR-1 in NC specification and reveal an unexpected connection between morphogenesis and cell fate.

Journal of Cell Science2区 · 生物学

Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex

2区 · 生物学

Article

作者: Michiru Nishita ; Ryosuke Doi ; Mitsuharu Endo ; Yasuhiro Minami

The Ror-family of receptor tyrosine kinases (RTKs), Ror1 and Ror2, have been shown to play crucial roles in the developmental morphogenesis by acting as receptors or co-receptors to mediate Wnt5a-induced signaling. Although Ror1, Ror2, and Wnt5a are expressed in the developing brain, little is known about their roles in the neural development. Here we show that Ror1, Ror2, and their ligand Wnt5a are highly expressed in neocortical neural progenitor cells (NPCs). siRNA-mediated suppression of Ror1, Ror2, or Wnt5a in cultured NPCs isolated from embryonic neocortex results in the reduction of βIII-tubulin-positive neurons that are produced from NPCs possibly through the generation of T-box brain 2 (Tbr2)-positive intermediate progenitors. BrdU-labeling experiments further reveal that proportion of proliferative and neurogenic NPCs, that are positive for neural progenitor cell marker (Pax6), but negative for glial cell marker (glial fibrillary acidic protein; GFAP), is reduced within a few days in culture following knockdown of these molecules, suggesting that Ror1, Ror2, and Wnt5a regulate neurogenesis through the maintenance of NPCs. Moreover, we show that Dishevelled2 (Dvl2) is involved in Wnt5a–Ror1 and Wnt5a–Ror2 signalings in NPCs, and that suppressed expression of Dvl2 indeed reduces the proportion of proliferative and neurogenic NPCs. Interestingly, suppressed or forced expression of either Ror1 or Ror2 in NPCs in the developing neocortex results in their precocious or delayed differentiation into neurons, respectively. Collectively, these results indicate that Wnt5a–Ror1 and Wnt5a–Ror2 signalings play roles in maintaining proliferative and neurogenic NPCs during neurogenesis of the developing neocortex.