LILRB4

MISGAV, Israel, Oct. 29, 2024 /PRNewswire/ -- Biond Biologics Ltd. ("Biond" or the "Company"), is a private clinical-stage biopharmaceutical company focusing on novel immunotherapies for cancer and innovative platforms for the intracellular delivery of biologics. Biond is pleased to announce a clinical trial collaboration and supply agreement with Merck KGaA, Darmstadt, Germany, to evaluate its immunotherapy agent BND-35 in combination with Merck KGaA, Darmstadt, Germany's anti-EGFR monoclonal antibody cetuximab (Erbitux®) in a Phase 1 clinical trial (BND-35-001, NCT06274437) for the treatment of patients with unresectable or metastatic solid tumors. Under the terms of this agreement, Merck KGaA, Darmstadt, Germany will supply Biond Biologics with cetuximab to support Biond's Phase 1 clinical trial, aimed at evaluating the safety and efficacy of BND-35 in combination with cetuximab. Enrollment to the BND-35 dose-escalation monotherapy arm has already begun and several patients have already been dosed. BND-35 is a novel anti-ILT3 (LILRB4) antibody that inhibits the interaction between ILT3 and various extracellular matrix ligands, including fibronectin, a major component of many tumor microenvironments (TME). ILT3 is expressed on myeloid suppressive cells and contributes to a pro-tumorigenic TME. Additionally, ILT3 reduces the effectiveness of targeted antibody therapies that leverage antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), immunological mechanisms known to eliminate tumor cells. BND-35 reprograms the suppressive TME to a more pro-inflammatory one and reverses the inhibitory effects of ILT3 on ADCC and ADCP mechanisms. "We are thrilled to partner with Merck KGaA, Darmstadt, Germany to secure the supply of cetuximab for our clinical trial and thank Merck KGaA, Darmstadt, Germany for their interest in BND-35" said Tal Sines, VP of Business Development at Biond Biologics. "Our preclinical data show that BND-35 can synergize with therapies such as cetuximab, that promote ADCC and ADCP activities. It could provide a potential new treatment option for patients with solid tumors. About BND-35 BND-35, an innovative anti-ILT3/LILRB4 antibody designed to remodel the tumor microenvironment. BND-35 is currently under evaluation as a monotherapy in a Phase 1 clinical trial, which is exploring the safety, tolerability, and potential anti-tumor activity of BND-35 (NCT06274437). BND-35 is being assessed as monotherapy in the BND-35-001 trial, and in combination with established anti-EGFR (cetuximab) and PD-L1 therapies across various indications. About Biond Biologics Biond Biologics stands at the cutting edge of innovative therapies that target novel oncology pathways and enable the intracellular delivery of biologics. The company is dedicated to leverage advanced science and pioneering technologies into transformative drugs for diseases with significant unmet medical needs. Biond Biologics actively seeks synergistic collaborations with leading biopharmaceutical entities to bring novel medicines to patients worldwide. The company's robust pipeline also includes BND-22 (SAR444881), a groundbreaking first-in-class ILT2-blocking antibody in partnership with Sanofi, and BND-67, targeting CD28 shedding, a newly discovered immune evasion mechanism. Additionally, Biond is advancing INspire, a revolutionary platform for the intracellular delivery of protein therapeutics, including antibodies, proteins, or enzymes into cells. Media Contact: Tal Sines VP of Business Development Biond Biologics Ltd. +972-4 884 4337 [email protected] SOURCE Biond Biologics Ltd. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

中国上海和香港，2024年10月5日–致力于研发，生产和销售同类首款及/或同类最优血液及实体肿瘤疗法的商业化阶段领先创新生物制药公司–德琪医药有限公司（简称“德琪医药”，香港交易所股票代码：6996.HK）今日宣布，公司将在计划于2024年11月6日至10日在美国圣休斯顿市举行的2024年癌症免疫治疗学会年会（SITC 2024）上公布三项研究成果。 壁报详情如下: ATG-201（CD19 x CD3 T细胞衔接器） 标题：ATG-201，一款新型“2+1”CD19靶向的T细胞衔接器，用于治疗B细胞恶性肿瘤及B细胞相关的自身免疫疾病 摘要编号：1067 SITC免疫工程研讨会壁报展示 日期：2024年11月7日时间：下午3:10 - 5:00（美国中部标准时间） 第三十九届SITC年会壁报展示 日期：2024年11月8日时间：上午9:00 - 下午7:00（美国中部标准时间） ATG-107（FLT3 x CD3 T细胞衔接器）标题：ATG-107，一款新型“2+1”FLT3靶向、基于CD3的T细胞衔接器，在治疗AML的临床前研究中展现出强效疗效摘要编号：1068SITC免疫工程研讨会壁报展示 日期：2024年11月7日时间：下午3:10 - 5:00（美国中部标准时间） 第三十九届SITC年会壁报展示 日期：2024年11月9日时间：上午9:00 - 下午8:30（美国中部标准时间） ATG-106（CDH6 x CD3 T细胞衔接器）标题：ATG-106，一款新型“2+1”CDH6靶向的T细胞衔接器，展示出强效的T细胞依赖性细胞毒性和体内抗肿瘤活性摘要编号：1069第三十九届SITC年会壁报展示 日期：2024年11月8日时间：上午9:00 - 下午7:00（美国中部标准时间） 关于AnTenGager™ 平台 AnTenGager™平台是德琪医药自主研发的T细胞衔接器（TCE）平台。它可以同时结合疾病相关抗原（DAA）和T细胞表达的CD3的独特的空间表位。通过二价结合DAA，它能有效识别并清除低靶抗原表达水平的细胞。此外，AnTenGager™ TCE只在存在DAA的情况下，条件性地激活T细胞，从而降低了系统性的CD3激活和细胞因子释放综合征（CRS）的风险。这为它在治疗自身免疫性疾病、血液系统恶性肿瘤和实体瘤等领域的应用提供了可能。 公司基于AnTenGager™的产品线丰富。这些TCE旨在协同解决自身免疫性疾病和血液学/肿瘤学领域未被满足的临床需求，并有望成为同类最佳或同类首创的解决方案。目前，我们已有一些处于临床启用阶段的主要项目，当中包括ATG-201，一款用于 B 细胞相关自身免疫性疾病的CD19 x CD3 TCE；ATG-102，一款用于急性髓系白血病和慢性粒单核细胞白血病的LILRB4 x CD3 TCE；ATG-106，一款用于卵巢癌和肾癌的CDH6 x CD3 TCE；ATG-107，一款用于急性髓系白血病的FLT3 x CD3 TCE；和ATG-110，一款用于微卫星稳定（MSS）结直肠癌的LY6G6D x CD3 TCE。 关于德琪医药    德琪医药有限公司（简称“德琪医药”，香港交易所股票代码：6996.HK）是一家以研发为驱动，并已进入商业化阶段的生物制药领先企业，以“医者无疆，创新永续”为愿景，德琪医药专注于血液及实体肿瘤领域的同类首款和同类最优疗法的早期研发、临床研究、药物生产及商业化，致力于通过提供突破性疗法，改善全球患者生活质量。 自2017年以来，德琪医药现已建立起一条拥有9款从临床延展至商业化阶段的肿瘤药物资产研发管线，其中，6款产品具有全球权益，3款产品具有亚太权益。公司已在美国及多个亚太市场获得29个临床批件（IND），并递交了10个新药上市申请（NDA）。目前，希维奥®（塞利尼索片）已获得中国大陆、中国台湾、中国香港、中国澳门、韩国、新加坡、马来西亚、泰国和澳大利亚的新药上市批准。 前瞻性陈述    本文所作出的前瞻性陈述仅与本文作出该陈述当日的事件或资料有关。除法律规定外，于作出前瞻性陈述当日之后，无论是否出现新资料、未来事件或其他情况，我们并无责任更新或公开修改任何前瞻性陈述及预料之外的事件。请细阅本文，并理解我们的实际未来业绩或表现可能与预期有重大差异。本文内有关任何董事或本公司意向的陈述或提述乃于本文刊发日期作出。任何该等意向均可能因未来发展而出现变动。有关这些因素和其他可能导致未来业绩与任何前瞻性声明存在重大差异的因素的进一步讨论，请参阅我们截至2023年12月31日的公司年报中描述的其他风险和不确定性，以及之后向香港证券交易所提交的文件。 Antengene to Present Results from Three Programs at the 2024 SITC Annual Meeting Shanghai and Hong Kong, PRC, October 5, 2024 — Antengene Corporation Limited (“Antengene”, SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced that it will present three programs at the 2024 Society of Immunology in Cancer Annual Meeting (SITC 2024) to be held in Houston from November 6-10, 2024. Details of Poster Presentations: ATG-201 (CD19 x CD3 T-cell Engager) Title: ATG-201, a novel “2+1” CD19-targeted T-cell Engager (TCE) for the treatment of B cell malignancies and B cell related autoimmune diseases Abstract Number: 1067 Poster Abstract Presentation at the SITC Immune Engineering Workshop Date: November 7, 2024 Time: 3:10 PM - 5:00 PM (Central Standard Time) Poster Presentation at the SITC 39th Annual Meeting Date: November 8, 2024 Time: 9:00 AM - 7:00 PM (Central Standard Time) ATG-107 (FLT3 x CD3 T-cell Engager) Title: ATG-107, a novel “2+1” CD3-based T-cell Engager (TCE) targeting FLT3, demonstrates potent preclinical efficacy for the treatment of AML Abstract Number: 1068 Poster Abstract Presentation at the SITC Immune Engineering Workshop Date: November 7, 2024 Time: 3:10 PM - 5:00 PM (Central Standard Time) Poster Presentation at the SITC 39th Annual Meeting Date: November 9, 2024 Time: 9:00 AM - 8:30 PM (Central Standard Time) ATG-106 (CDH6 x CD3 T-cell Engager) Title: ATG-106, a novel “2+1” format CDH6-targeted T-cell Engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy Abstract Number: 1069 Poster Presentation at the SITC 39th Annual Meeting Date: November 8, 2024 Time: 9:00 AM - 7:00 PM (Central Standard Time) About the AnTenGager™ Platform  The AnTenGager™ Platform is a proprietary “2+1” T cell engager (TCE) platform developed by Antengene.  AnTenGager™ TCE simultaneously binds to disease-associated antigens (targets) and a unique conformational epitope on CD3 that expressed on T-cells. The bivalent binding to the targets enables detection and depletion of cells with low expression of the targets. In addition, AnTenGager™ TCE activates T cells in a target-dependent manner so that it demonstrates a lower risk of systemic CD3 activation and cytokine release syndrome (CRS), potentially paving the way for their use in autoimmune diseases, hematological malignancies, and solid tumors. Our extensive and diverse pipeline features promising TCEs that aim to address unmet medical needs in autoimmune diseases and hematology/oncology, with best-in-class/first-in-class potential. A few of our lead programs in the IND-enabling stage include ATG-201, a CD19 x CD3 TCE for B cell related autoimmune diseases; ATG-102, a LILRB4 x CD3 TCE for acute myeloid leukemia (AML) and chronic myelomonocytic leukemia; ATG-106, a CDH6 x CD3 TCE for ovarian cancer and kidney cancer; ATG-107, a FLT3 x CD3 TCE for AML; and ATG-110, a LY6G6D x CD3 TCE for microsatellite stable (MSS) colorectal cancer. About Antengene    Antengene Corporation Limited (“Antengene”, SEHK: 6996.HK) is a leading commercial-stage R&D-driven global biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of innovative first-in-class/best-in-class therapeutics for the treatment of hematologic malignancies and solid tumors, in realizing its vision of “Treating Patients Beyond Borders”. Since 2017, Antengene has built a pipeline of 9 oncology assets at various stages going from clinical to commercial, including 6 with global rights, and 3 with rights for the APAC region. To date, Antengene has obtained 29 investigational new drug (IND) approvals in the U.S. and Asia, and submitted 10 new drug applications (NDAs) in multiple Asia Pacific markets, with the NDA for XPOVIO® (selinexor) already approved in Mainland of China, Taiwan China, Hong Kong China, Macau China, South Korea, Singapore, Malaysia, Thailand and Australia. Forward-looking statements    The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, please see the other risks and uncertainties described in the Company’s Annual Report for the year ended December 31, 2023, and the documents subsequently submitted to the Hong Kong Stock Exchange.

SHANGHAI and HONG KONG, Oct. 4, 2024 /PRNewswire/ -- Antengene Corporation Limited (" Antengene", SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced that it will present three programs at the 2024 Society of Immunology in Cancer Annual Meeting (SITC 2024) to be held in Houston from November 6-10, 2024. Details of Poster Presentations: ATG-201 (CD19 x CD3 T-cell Engager) Title: ATG-201, a novel "2+1" CD19-targeted T-cell Engager (TCE) for the treatment of B cell malignancies and B cell related autoimmune diseases Abstract Number: 1067 Poster Abstract Presentation at the SITC Immune Engineering Workshop Date: November 7, 2024 Time: 3:10 PM - 5:00 PM (Central Standard Time) 5:10 AM – 7:00 AM, Nov 8, 2024 (Beijing Time) Poster Presentation at the SITC 39th Annual Meeting Date: November 8, 2024 Time: 9:00 AM - 7:00 PM (Central Standard Time) 11:00 PM, Nov 8 – 9:00 AM, Nov 9, 2024 (Beijing Time) ATG-107 (FLT3 x CD3 T-cell Engager) Title: ATG-107, a novel "2+1" CD3-based T-cell Engager (TCE) targeting FLT3, demonstrates potent preclinical efficacy for the treatment of AML Abstract Number: 1068 Poster Abstract Presentation at the SITC Immune Engineering Workshop Date: November 7, 2024 Time: 3:10 PM - 5:00 PM (Central Standard Time) 5:10 AM – 7:00 AM, Nov 8, 2024 (Beijing Time) Poster Presentation at the SITC 39th Annual Meeting Date: November 9, 2024 Time: 9:00 AM - 8:30 PM (Central Standard Time) 11:00 PM, Nov 9 – 10:30 AM, Nov 10, 2024 (Beijing Time) ATG-106 (CDH6 x CD3 T-cell Engager) Title: ATG-106, a novel "2+1" format CDH6-targeted T-cell Engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy Abstract Number: 1069 Poster Presentation at the SITC 39th Annual Meeting Date: November 8, 2024 Time: 9:00 AM - 7:00 PM (Central Standard Time) 11:00 PM, Nov 8 – 9:00 AM, Nov 9, 2024 (Beijing Time) About the AnTenGager™ Platform The AnTenGager™ Platform is a proprietary "2+1" T cell engager (TCE) platform developed by Antengene. AnTenGager™ TCE simultaneously binds to disease-associated antigens (targets) and a unique conformational epitope on CD3 that expressed on T-cells. The bivalent binding to the targets enables detection and depletion of cells with low expression of the targets. In addition, AnTenGager™ TCE activates T cells in a target-dependent manner so that it demonstrates a lower risk of systemic CD3 activation and cytokine release syndrome (CRS), potentially paving the way for their use in autoimmune diseases, hematological malignancies, and solid tumors. Our extensive and diverse pipeline features promising TCEs that aim to address unmet medical needs in autoimmune diseases and hematology/oncology, with best-in-class/first-in-class potential. A few of our lead programs in the IND-enabling stage include ATG-201, a CD19 x CD3 TCE for B cell related autoimmune diseases; ATG-102, a LILRB4 x CD3 TCE for acute myeloid leukemia (AML) and chronic myelomonocytic leukemia; ATG-106, a CDH6 x CD3 TCE for ovarian cancer and kidney cancer; ATG-107, a FLT3 x CD3 TCE for AML; and ATG-110, a LY6G6D x CD3 TCE for microsatellite stable (MSS) colorectal cancer. About Antengene Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) is a leading commercial-stage R&D-driven global biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of innovative first-in-class/best-in-class therapeutics for the treatment of hematologic malignancies and solid tumors, in realizing its vision of "Treating Patients Beyond Borders". Since 2017, Antengene has built a pipeline of 9 oncology assets at various stages going from clinical to commercial, including 6 with global rights, and 3 with rights for the APAC region. To date, Antengene has obtained 29 investigational new drug (IND) approvals in the U.S. and Asia, and submitted 10 new drug applications (NDAs) in multiple Asia Pacific markets, with the NDA for XPOVIO® (selinexor) already approved in Mainland of China, Taiwan China, Hong Kong China, Macau China, South Korea, Singapore, Malaysia, Thailand, and Australia. Forward-looking statements The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, please see the other risks and uncertainties described in the Company's Annual Report for the year ended December 31, 2023, and the documents subsequently submitted to the Hong Kong Stock Exchange. SOURCE Antengene Corporation Limited WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED