别名 KIAA0998、SRC1 and TIF2-associated modulatory protein、STAMP + [5] |
简介 Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (PubMed:22493317). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691). |
作用机制 Bcr-Abl抑制剂 [+1] |
原研机构 |
在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2021-10-29 |
开始日期2025-06-01 |
开始日期2025-02-18 |
开始日期2025-02-14 |
申办/合作机构 |